Iron and Mycobacterium tuberculosis infection

Lounis, Nacer; Truffot-Pernot, Chantal; Grosset, Jacques; Gordeuk, Victor R.; Boelaert, Johan R.

doi:10.1016/s1386-6532(00)00136-0

Cited by 142Tuberculosis Research and EpidemiologyIron Metabolism and DisordersInfectious Diseases and Tuberculosis

Iron and Mycobacterium tuberculosis infection

Lounis, Nacer, Truffot-Pernot, Chantal, Grosset, Jacques, Gordeuk, Victor R., Boelaert, Johan R.·2001·Journal of Clinical Virology

DOI 10.1016/s1386-6532(00)00136-0

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Abstract

Background iron is known to play a role in the susceptibility to and outcome of several infections. In view of the increasing worldwide problem of tuberculosis, it may be important to ascertain whether this is also the case with this infection.Objectives (1) to review studies conducted in vitro, in experimental animals, and in humans that provide evidence that iron status may influence the occurrence and outcome of tuberculosis. (2) To perform an in vivo study in mice, examining the effect of iron loading on experimental infection caused by a virulent strain of Mycobacterium tuberculosis.Results we studied the effect of iron loading on the growth in spleen and lungs of a virulent strain of M. tuberculosis, injected i.v. in female Balb/C mice. At sacrifice on day 42 after the experimental infection, the iron-loaded mice presented a significantly enhanced multiplication of M. tuberculosis in both the spleen and the lungs, when compared to the mice without iron loading.Conclusion Most of the studies, including our experimental study in mice, tend to suggest that an excess of iron may enhance the growth of M. tuberculosis and worsen the outcome of human tuberculosis.

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Self-citation

Impact of iron loading and iron chelation on murine tuberculosis
Lounis, N., Maslo, C., Boelaert, J. R., Bonnafous, P., Truffot-Pernot, C., Ji, B., & Grosset, J. H. E. (1999) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.1999.tb00514.x · Cited by 9 · see citing works
Self-citation
The Effect of the Host’s Iron Status on Tuberculosis
Boelaert, J. R., Vandecasteele, S. J., Appelberg, R., & Gordeuk, V. R. (2007) · The Journal of Infectious Diseases · doi:10.1086/518040 · Cited by 217 · see citing works
Self-citation
Effect of Iron Supplementation on the Outcome of Non-Progressive Pulmonary Mycobacterium tuberculosis Infection
Kolloli, A., Singh, P., Rodríguez, G. M., & Subbian, S. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081155 · Cited by 13 · see citing works
The Effect of Iron on the Expression of Cytokines in Macrophages Infected with Mycobacterium tuberculosis
Serafín-López, J., Chacón-Salinas, R., Muñoz-Cruz, S., Enciso-Moreno, J. A., Estrada-Parra, S., & Estrada-García, I. (2004) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2004.01482.x · Cited by 30 · see citing works
[Establishment of an Iron-overloaded Mouse Model with Tuberculosis and Analysis of the Iron Metabolism Index].
Li, J., Shi, Y.-N., & Zhan, L. (2021) · PubMed · doi:10.3881/j.issn.1000-503x.13336

Authors: Lounis, N., Truffot-Pernot, C., Grosset, J., Gordeuk, V. R., & Boelaert, J. R.
Affiliations: Sorbonne Université (FR)
Howard University (US)
AZ Sint-Jan (BE)
Corresponding author: Boelaert, Johan R.
ORCID: Gordeuk, Victor R.
Venue: Journal of Clinical Virology
Publisher: Elsevier BV
Published: 2001-02
Volume: 20
Issue: 3
Pages: 123-126
ISSN: 1386-6532 (ISSN-L)
DOI: 10.1016/s1386-6532(00)00136-0
OpenAlex: W2030633873
Cited by: 142
References: 18
Citations by year: 2026: 3 · 2025: 4 · 2024: 4 · 2023: 5 · 2021: 6 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 8 · 2012: 11
FWCI: 3.86
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Clinical Virology (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (5UH1-HL-03679-02, UH1HL003679)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Surgery › Infectious Diseases and Tuberculosis
Keywords: iron status, Mycobacterium tuberculosis, tuberculosis, iron overload, bacterial growth, spleen, lung, host susceptibility to infection
MeSH terms: Animals, Disease Susceptibility, Female, Ferric Compounds, Haptoglobins, Humans, Iron, Lung, Macrophages, Mice, Inbred BALB C, Mycobacterium tuberculosis, Polysaccharides, Spleen, Tuberculosis, HIV Infections, Iron Overload, Mice

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