The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury
Open accessAbstract
Globins are oxygen-binding heme proteins present in bacteria, protists, fungi, plants, and animals. Their functions have diverged widely in evolution, and include binding, transport, scavenging, detoxification, and sensing of gases like oxygen, nitric oxide, and carbon monoxide. Neuroglobin (Ngb) is a recently discovered monomeric globin with high affinity for oxygen and preferential localization to vertebrate brain. No function for Ngb is known, but its affinity for oxygen and its expression in cerebral neurons suggest a role in neuronal responses to hypoxia or ischemia. Here we report that Ngb expression is increased by neuronal hypoxia in vitro and focal cerebral ischemia in vivo , and that neuronal survival after hypoxia is reduced by inhibiting Ngb expression with an antisense oligodeoxynucleotide and enhanced by Ngb overexpression. Both induction of Ngb and its protective effect show specificity for hypoxia over other stressors. We conclude that hypoxia-inducible Ngb expression helps promote neuronal survival from hypoxic-ischemic insults.
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Cites
Reversible middle cerebral artery occlusion without craniectomy in rats.
Longa, E. Z., Weinstein, P. R., Carlson, S., & Cummins, R. (1989) · Stroke · doi:10.1161/01.str.20.1.84 · Cited by 7,463
Cited by
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
Jin, K., Zhu, Y., Sun, Y., Mao, X. O., Xie, L., & Greenberg, D. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182296499 · Cited by 1,507
Self-citationFernando, M. S., Simpson, J. E., Matthews, F., Brayne, C., Lewis, C. E., Barber, R., Kalaria, R. N., Forster, G., Esteves, F., Wharton, S. B., et al. (2006) · Stroke · doi:10.1161/01.str.0000221308.94473.14 · Cited by 587
Maia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401
Neuroglobin protects the brain from experimental stroke in vivo
Sun, Y., Jin, K., Peel, A., Mao, X. O., Xie, L., & Greenberg, D. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0637726100 · Cited by 354
Self-citationSchmidt, M., Giessl, A., Laufs, T., Hankeln, T., Wolfrum, U., & Burmester, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209909200 · Cited by 316
Metadata
- Authors
- Sun, Y., Jin, K., Mao, X. O., Zhu, Y., & Greenberg, D. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-12-11
- Volume
- 98
- Issue
- 26
- Pages
- 15306-15311
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W4236819860
- Cited by
- 447
- References
- 1
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Sun, Y., Jin, K., Mao, X. O., Zhu, Y., & Greenberg, D. A. (2001). Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic injury. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.251466698
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