The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Regulation of somatic growth by the p160 coactivator p/CIP
Open accessAbstract
A family of p160 coactivators was initially identified based on ligand-dependent interactions with nuclear receptors and thought to function, in part, by recruiting CREB-binding protein/p300 to several classes of transcription factors. One of the p160 factors, p/CIP/AIB1, often amplified and overexpressed in breast cancer, also exhibits particularly strong interaction with CREB-binding protein/p300. In this manuscript, we report that p/CIP, which exhibits regulated transfer from cytoplasm to nucleus, is required for normal somatic growth from embryonic day 13.5 through maturity. Our data suggest that a short stature phenotype of p/CIP gene-deleted mice reflect both altered regulation of insulin-like growth factor-1 (IGF-1) gene expression in specific tissues and a cell-autonomous defect of response to IGF-1, including ineffective transcriptional activities by several classes of regulated transcription factors under specific conditions. The actions of p/CIP are therefore required for full expression of a subset of genes critical for regulating physiological patterns of somatic growth in mammals.
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Citations
Cites
The coregulator exchange in transcriptional functions of nuclear receptors
Glass, C. K., & Rosenfeld, M. G. (2000) · Genes & Development · doi:10.1101/gad.14.2.121 · Cited by 2,233
Self-citation
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MacFarlane, L.-A., & R. Murphy, P. (2010) · Current Genomics · doi:10.2174/138920210793175895 · Cited by 1,584
Combinatorial Control of Gene Expression by Nuclear Receptors and Coregulators
McKenna, N. J., & O'Malley, B. W. (2002) · Cell · doi:10.1016/s0092-8674(02)00641-4 · Cited by 1,463
Coregulator Function: A Key to Understanding Tissue Specificity of Selective Receptor Modulators
Smith, C. L., & O’Malley, B. W. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0023 · Cited by 931
Coregulator codes of transcriptional regulation by nuclear receptors
Rosenfeld, M. G., & Glass, C. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100041200 · Cited by 509
Self-citationRetinoic acid receptors: From molecular mechanisms to cancer therapy
di Masi, A., Leboffe, L., De Marinis, E., Pagano, F., Cicconi, L., Rochette-Egly, C., Lo-Coco, F., Ascenzi, P., & Nervi, C. (2015) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2014.12.003 · Cited by 403
Metadata
- Authors
- Wang, Z., Rose, D. W., Hermanson, O., Liu, F., Herman, T., Wu, W., Szeto, D., Gleiberman, A., Krones, A., Pratt, K., Rosenfeld, R., Glass, C. K., & Rosenfeld, M. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-11-21
- Volume
- 97
- Issue
- 25
- Pages
- 13549-13554
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2061619516
- Cited by
- 192
- References
- 1
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, Z., Rose, D. W., Hermanson, O., Liu, F., Herman, T., Wu, W., Szeto, D., Gleiberman, A., Krones, A., Pratt, K., Rosenfeld, R., Glass, C. K., & Rosenfeld, M. G. (2000). Regulation of somatic growth by the p160 coactivator p/CIP. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.260463097
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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