The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction
Open accessAbstract
The coxsackievirus and adenovirus receptor (CAR) mediates viral attachment and infection, but its physiologic functions have not been described. In nonpolarized cells, CAR localized to homotypic intercellular contacts, mediated homotypic cell aggregation, and recruited the tight junction protein ZO-1 to sites of cell–cell contact. In polarized epithelial cells, CAR and ZO-1 colocalized to tight junctions and could be coprecipitated from cell lysates. CAR expression led to reduced passage of macromolecules and ions across cell monolayers, and soluble CAR inhibited the formation of functional tight junctions. Virus entry into polarized epithelium required disruption of tight junctions. These results indicate that CAR is a component of the tight junction and of the functional barrier to paracellular solute movement. Sequestration of CAR in tight junctions may limit virus infection across epithelial surfaces.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Occludin: a novel integral membrane protein localizing at tight junctions.
Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.123.6.1777 · Cited by 2,580
Recognition of Unique Carboxyl-Terminal Motifs by Distinct PDZ Domains
Songyang, Z., Fanning, A. S., Fu, C., Xu, J., Marfatia, S. M., Chishti, A. H., Crompton, A., Chan, A. C., Anderson, J. M., & Cantley, L. C. (1997) · Science · doi:10.1126/science.275.5296.73 · Cited by 1,385
Transmembrane proteins in the tight junction barrier
FANNING, A. S., MITIC, L. L., & ANDERSON, J. M. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1061337 · Cited by 301
Cited by
Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components1,2
Ulluwishewa, D., Anderson, R. C., McNabb, W. C., Moughan, P. J., Wells, J. M., & Roy, N. C. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.135657 · Cited by 1,177
Berkes, J., Viswanathan, V. K., Savkovic, S. D., & Hecht, G. (2003) · Gut · doi:10.1136/gut.52.3.439 · Cited by 601
The role of junctional adhesion molecules in vascular inflammation
Weber, C., Fraemohs, L., & Dejana, E. (2007) · Nature Reviews Immunology · doi:10.1038/nri2096 · Cited by 503
Groeger, S., & Meyle, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00208 · Cited by 473
Transmembrane proteins of tight junctions
Chiba, H., Osanai, M., Murata, M., Kojima, T., & Sawada, N. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.017 · Cited by 464
Metadata
- Authors
- Cohen, C. J., Shieh, J. T. C., Pickles, R. J., Okegawa, T., Hsieh, J.-T., & Bergelson, J. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-12-04
- Volume
- 98
- Issue
- 26
- Pages
- 15191-15196
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2005127084
- Cited by
- 698
- References
- 3
- FWCI
- 27.32
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. https://app.cochat.ai/papers/10.1073/pnas.261452898
- The paper
- Cohen, C. J., Shieh, J. T. C., Pickles, R. J., Okegawa, T., Hsieh, J.-T., & Bergelson, J. M. (2001). The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.261452898
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
