Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components1,2

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

Farquhar, M. G., & Palade, G. E. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.2.375 · Cited by 3,637 · see citing works

Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine

Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358 · see citing works

Regulation of Myosin Phosphatase by Rho and Rho-Associated Kinase (Rho-Kinase)

Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., et al. (1996) · Science · doi:10.1126/science.273.5272.245 · Cited by 2,889 · see citing works

Occludin: a novel integral membrane protein localizing at tight junctions.

Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.123.6.1777 · Cited by 2,580 · see citing works

Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers

Peng, L., Li, Z.-R., Green, R. S., Holzmanr, I. R., & Lin, J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.104638 · Cited by 2,130 · see citing works

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.7.1539 · Cited by 2,100 · see citing works

Stem cells, self-renewal, and differentiation in the intestinal epithelium.

van der Flier, L. G., & Clevers, H. (2009) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163145 · Cited by 1,859 · see citing works

The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton

Fanning, A. S., Jameson, B. J., Jesaitis, L. A., & Anderson, J. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29745 · Cited by 1,432 · see citing works

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

Martín-Padura, I., Lostaglio, S., Schneemann, M., Williams, L., Romano, M., Fruscella, P., Panzeri, C., Stoppacciaro, A., Ruco, L., Villa, A., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.117 · Cited by 1,387 · see citing works

Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins

Itoh, M., Furuse, M., Morita, K., Kubota, K., Saitou, M., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.6.1351 · Cited by 1,151 · see citing works

Probiotic bacteria enhance murine and human intestinal epithelial barrier function

Madsen, K., Cornish, A. S., Soper, P., McKaigney, C. J., Jijon, H. B., Yachimec, C., Doyle, J. S. G., Jewell, L. D., & Simone, C. D. (2001) · Gastroenterology · doi:10.1053/gast.2001.27224 · Cited by 1,096 · see citing works

The MAPK cascades: Signaling components, nuclear roles and mechanisms of nuclear translocation

Plotnikov, A. N., Zehorai, E., Procaccia, S., & Seger, R. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2010.12.012 · Cited by 990 · see citing works

A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

Furuse, M., Sasaki, H., Fujimoto, K., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.2.391 · Cited by 969 · see citing works

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein.

Balda, M. S., Whitney, J. A., Flores, C., González, S., Cereijido, M., & Matter, K. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.4.1031 · Cited by 876 · see citing works

The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor α in the pathogenesis of non-alcoholic steatohepatitis

Wigg, A. J., Roberts-Thomson, I. C., Dymock, R. B., McCarthy, P. J., Grose, R. H., & Cummins, A. G. (2001) · Gut · doi:10.1136/gut.48.2.206 · Cited by 836 · see citing works

Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells

Ikenouchi, J., Furuse, M., Furuse, K., Sasaki, H., Tsukita, S., & Tsukita, S. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200510043 · Cited by 787 · see citing works

The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction

Cohen, C. J., Shieh, J. T. C., Pickles, R. J., Okegawa, T., Hsieh, J., & Bergelson, J. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261452898 · Cited by 702 · see citing works

Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function

Cario, E., Gerken, G., & Podolsky, D. K. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.056 · Cited by 697 · see citing works

Oral drug absorption enhancement by chitosan and its derivatives

Thanou, M., Verhoef, J. C., & Junginger, H. E. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00231-9 · Cited by 689 · see citing works

Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier

Karczewski, J., Troost, F. J., Konings, I., Dekker, J., Kleerebezem, M., Brummer, R.-J. M., & Wells, J. M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00327.2009 · Cited by 676 · see citing works

Secreted bioactive factors from <i>Bifidobacterium infantis</i> enhance epithelial cell barrier function

Ewaschuk, J. B., Diaz, H., Meddings, L., Diederichs, B., Dmytrash, A., Backer, J., Looijer-van Langen, M., & Madsen, K. L. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90227.2008 · Cited by 590 · see citing works

Chitosans as Absorption Enhancers for Poorly Absorbable Drugs 2: Mechanism of Absorption Enhancement

Schipper, N. G. M., Olsson, S., Hoogstraate, J. A., deBoer, A. G., Vårum, K. M., & Artursson, P. (1997) · Pharmaceutical Research · doi:10.1023/a:1012160102740 · Cited by 588 · see citing works

Desmosome structure, composition and function

Garrod, D. R., & Chidgey, M. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.07.014 · Cited by 581 · see citing works

Epithelial crosstalk at the microbiota–mucosal interface

Wells, J. M., Rossi, O., Meijerink, M., & van Baarlen, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000092107 · Cited by 574 · see citing works

Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation

Turner, J. R., Rill, B. K., Carlson, S. L., Carnes, D., Kerner, R., Mrsny, R. J., & Madara, J. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.4.c1378 · Cited by 553 · see citing works

Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3

Lammers, K. M., Lu, R., Brownley, J., Lu, B., Gerard, C. J., Thomas, K., Rallabhandi, P., Shea‐Donohue, T., Tamiz, A. P., Alkan, Ş. Ş., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.023 · Cited by 545 · see citing works

Human junction adhesion molecule regulates tight junction resealing in epithelia

Liu, Y., Nusrat, A., Schnell, F. J., Reaves, T. A., Walsh, S. V., Pochet, M., & Parkos, C. A. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.13.2363 · Cited by 525 · see citing works

Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation

Anderson, R. C., Cookson, A. L., McNabb, W. C., Park, Z., McCann, M. J., Kelly, W. J., & Roy, N. C. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-316 · Cited by 510 · see citing works

Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines

Drago, S., Asmar, R. E., Pierro, M. D., Clemente, M. G., Sapone, A., Thakar, M., Iacono, G., Carroccio, A., DʼAgate, C., Not, T., et al. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520500235334 · Cited by 503 · see citing works

Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity

Ukena, S. N., Singh, A., Dringenberg, U., Engelhardt, R., Seidler, U., Hansen, W., Bleich, A., Bruder, D., Franzke, A., Rogler, G., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001308 · Cited by 482 · see citing works

Interaction of Junctional Adhesion Molecule with the Tight Junction Components ZO-1, Cingulin, and Occludin

Bazzoni, G., Martínez-Estrada, O. M., Orsenigo, F., Cordenonsi, M., Citi, S., & Dejana, E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m905251199 · Cited by 480 · see citing works

Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C

Cario, E., Gerken, G., & Podolsky, D. K. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.015 · Cited by 475 · see citing works

PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane

Fanning, A. S., & Anderson, J. M. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6509 · Cited by 471 · see citing works

Human zonulin, a potential modulator of intestinal tight junctions

Wang, W., Uzzau, S., Goldblum, S. E., & Fasano, A. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.24.4435 · Cited by 470 · see citing works

Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure

Shen, L., Black, E. D., Witkowski, E. D., Lencer, W. I., Guerriero, V., Schneeberger, E. E., & Turner, J. R. (2006) · Journal of Cell Science · doi:10.1242/jcs.02915 · Cited by 467 · see citing works

Transmembrane proteins of tight junctions

Chiba, H., Osanai, M., Murata, M., Kojima, T., & Sawada, N. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.017 · Cited by 464 · see citing works

Is Lactobacillus GG helpful in children with Crohn’s disease? Results of a preliminary, open-label study

Gupta, P., Andrew, H., Kirschner, B. S., & Guandalini, S. (2000) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200010000-00024 · Cited by 429 · see citing works

Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKC? redistribution resulting in tight junction and epithelial barrier repair

Zyrek, A. A., Cichon, C., Helms, S., Enders, C., Sonnenborn, U., & Schmidt, M. A. (2006) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00836.x · Cited by 427 · see citing works

Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress

Zareie, M., Johnson‐Henry, K. C., Jury, J., Yang, P.-C., Ngan, B., McKay, D. M., Söderholm, J. D., Perdue, M. H., & Sherman, P. M. (2006) · Gut · doi:10.1136/gut.2005.080739 · Cited by 423 · see citing works

Rho protein regulates tight junctions and perijunctional actin organization in polarized epithelia.

Nusrat, A., Giry, M., Turner, J. R., Colgan, S. P., Parkos, C. A., Carnes, D. K., Lemichez, E., Boquet, P., & Madara, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.23.10629 · Cited by 418 · see citing works

Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function

Clemente, M. G. (2003) · Gut · doi:10.1136/gut.52.2.218 · Cited by 415 · see citing works

Molecular Basis of the Core Structure of Tight JunctionsPreprint

Furuse, M. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002907 · Cited by 410 · see citing works

Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease

Suenaert, P., Bulteel, V., Lemmens, L., Noman, M., Geypens, B. J., Assche, G. V., Geboes, K. J., Ceuppens, J. L., & Rutgeerts, P. J. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05914.x · Cited by 402 · see citing works

Junctional adhesion molecule (JAM) binds to PAR-3

Itoh, M., Sasaki, H., Furuse, M., Ozaki, H., Kita, T., & Tsukita, S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200103047 · Cited by 385 · see citing works

Tumor necrosis factor-alpha (TNFα) regulates the epithelial barrier in the human intestinal cell line HT-29/B6

Schmitz, H., Fromm, M., Bentzel, C. J., Scholz, P., Detjen, K. M., Mankertz, J., Bode, H., Epple, H., Riecken, E., & Schulzke, J. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.1.137 · Cited by 375 · see citing works

Intestinal absorptive cell tight junctions are linked to cytoskeleton

Madara, J. (1987) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1987.253.1.c171 · Cited by 342 · see citing works

Absorption Enhancement through Intracellular Regulation of Tight Junction Permeability by Medium Chain Fatty Acids in Caco-2 Cells

Lindmark, T., Kimura, Y., & Artursson, P. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37216-7 · Cited by 333 · see citing works

The JAM family of junctional adhesion molecules

Bazzoni, G. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00104-2 · Cited by 327 · see citing works

Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats

Watts, T. L., Berti, I., Sapone, A., Gerarduzzi, T., Not, T., Zielke, R. H., & Fasano, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500178102 · Cited by 313 · see citing works

Probiotics and Commensals Reverse TNF-α– and IFN-γ–Induced Dysfunction in Human Intestinal Epithelial Cells

Resta‐Lenert, S. C., & Barrett, K. E. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.12.015 · Cited by 308 · see citing works

Quercetin Enhances Intestinal Barrier Function through the Assembly of Zonnula Occludens-2, Occludin, and Claudin-1 and the Expression of Claudin-4 in Caco-2 Cells

Suzuki, T., & Hara, H. (2009) · Journal of Nutrition · doi:10.3945/jn.108.100867 · Cited by 303 · see citing works

Isolation and functional characterization of the actin‐binding region in the tight junction protein ZO‐1

Fanning, A. S., Ma, T. Y., & Anderson, J. M. (2002) · The FASEB Journal · doi:10.1096/fj.02-0121fje · Cited by 296 · see citing works

Catenins: Keeping Cells from Getting Their Signals Crossed

Pérez‐Moreno, M., & Fuchs, E. V. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.10.010 · Cited by 295 · see citing works

Fibre and effects on probiotics (the prebiotic concept)

Gibson, G. R. (2004) · Clinical Nutrition Supplements · doi:10.1016/j.clnu.2004.09.005 · Cited by 288 · see citing works

Phosphorylation of occludin correlates with occludin localization and function at the tight junction

Wong, V. (1997) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1997.273.6.c1859 · Cited by 288 · see citing works

L-glutamine stimulates intestinal cell proliferation and activates mitogen-activated protein kinases

Rhoads, J. M., Argenzio, R. A., Chen, W., Rippe, R. A., Westwick, J. K., Cox, A. D., Berschneider, H. M., & Brenner, D. A. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.5.g943 · Cited by 277 · see citing works

MAPK interacts with occludin and mediates EGF-induced prevention of tight junction disruption by hydrogen peroxide

Basuroy, S., Seth, A., Elias, B. C., Naren, A. P., & Rao, R. (2005) · Biochemical Journal · doi:10.1042/bj20050959 · Cited by 257 · see citing works

Structural organization of gap junction channels

Sosinsky, G. E., & Nicholson, B. J. (2005) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2005.04.001 · Cited by 251 · see citing works

Regulation and roles for claudin‐family tight junction proteins

Findley, M. K., & Koval, M. H. (2009) · IUBMB Life · doi:10.1002/iub.175 · Cited by 224 · see citing works

RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actin

Bruewer, M., Hopkins, A. M., Hobert, M. E., Nusrat, A., & Madara, J. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00087.2004 · Cited by 223 · see citing works

Acute stressors stimulate ion secretion and increase epithelial permeability in rat intestine

Saunders, P. R., Kosecka, U., McKay, D. M., & Perdue, M. H. (1994) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1994.267.5.g794 · Cited by 215 · see citing works

A secreted Salmonella protein with homology to an avirulence determinant of plant pathogenic bacteria

Hardt, W., & Galán, J. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9887 · Cited by 212 · see citing works

Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia

Walsh, S. V., Hopkins, A. M., Chen, J. Z., Narumiya, S., Parkos, C. A., & Nusrat, A. (2001) · Gastroenterology · doi:10.1053/gast.2001.27060 · Cited by 211 · see citing works

Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase–dependent fashion

Scott, K. G. –., Meddings, J. B., Kirk, D. R., Lees‐Miller, S. P., & Buret, A. G. (2002) · Gastroenterology · doi:10.1053/gast.2002.36002 · Cited by 207 · see citing works

Zinc Deficiency Induces Membrane Barrier Damage and Increases Neutrophil Transmigration in Caco-2 Cells1,

Finamore, A., Massimi, M., Devirgiliis, L. C., & Mengheri, E. (2008) · Journal of Nutrition · doi:10.1093/jn/138.9.1664 · Cited by 199 · see citing works

Lactobacillus plantarum DSM 2648 is a potential probiotic that enhances intestinal barrier function

Anderson, R. C., Cookson, A. L., McNabb, W. C., Kelly, W. J., & Roy, N. C. (2010) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2010.02038.x · Cited by 194 · see citing works

Tight junctions, leaky intestines, and pediatric diseases

Liu, Z., Li, N., & Neu, J. (2005) · Acta Paediatrica · doi:10.1111/j.1651-2227.2005.tb01904.x · Cited by 188 · see citing works

Glutamine regulates Caco-2 cell tight junction proteins

Li, N., Lewis, P., Samuelson, D. A., Liboni, K., & Neu, J. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00012.2004 · Cited by 186 · see citing works

Quercetin Enhances Epithelial Barrier Function and Increases Claudin-4 Expression in Caco-2 Cells3

Amasheh, M., Schlichter, S., Amasheh, S., Mankertz, J., Zeitz, M., Fromm, M., & Schulzke, J. D. (2008) · Journal of Nutrition · doi:10.1093/jn/138.6.1067 · Cited by 181 · see citing works

L. plantarum prevents Enteroinvasive Escherichia coli-induced tight junction proteins changes in intestinal epithelial cells

Qin, H., Zhang, Z., Hang, X., & Jiang, Y. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-63 · Cited by 175 · see citing works

Ethanol-Induced Barrier Dysfunction and Its Prevention by Growth Factors in Human Intestinal Monolayers: Evidence for Oxidative and Cytoskeletal Mechanisms

Banan, A., Choudhary, S., Zhang, Y., Fields, J. Z., & Keshavarzian, A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35212-7 · Cited by 165 · see citing works

Transmembrane proteins of tight junctions

Balda, M. S., & Matter, K. (2000) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.2000.0177 · Cited by 154 · see citing works

Thermodynamic and Kinetic Characterization of the Interaction between the Ras Binding Domain of AF6 and Members of the Ras Subfamily

Linnemann, T., Geyer, M., Jaitner, B. K., Block, C., Kalbitzer, H. R., Wittinghofer, A., & Herrmann, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13556 · Cited by 133 · see citing works

Dimerization of the Scaffolding Protein ZO-1 through the Second PDZ Domain

Utepbergenov, D., Fanning, A. S., & Anderson, J. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512820200 · Cited by 127 · see citing works

Salmonella Type III Effector AvrA Stabilizes Cell Tight Junctions to Inhibit Inflammation in Intestinal Epithelial Cells

Liao, A. P., Petrof, E. O., Kuppireddi, S., Zhao, Y., Xia, Y., Claud, E. C., & Sun, J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002369 · Cited by 121 · see citing works

Multiple sclerosis patients have peripheral blood CD45RO+ B cells and increased intestinal permeability

Yacyshyn, B., Meddings, J. B., Sadowski, D. C., & Bowen-Yacyshyn, M. B. (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02100148 · Cited by 116 · see citing works

Effect of natural commensal-origin DNA on toll-like receptor 9 (TLR9) signaling cascade, chemokine IL-8 expression, and barrier integritiy of polarized intestinal epithelial cells

Ghadimi, D., de Vrese, M., Heller, K. J., & Schrezenmeir, J. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21057 · Cited by 113 · see citing works

Effect of four probiotic strains and Escherichia coli O157:H7 on tight junction integrity and cyclo-oxygenase expression

Putaala, H., Salusjärvi, T., Nordström, M., Saarinen, M., Ouwehand, A. C., Hansen, E. B., & Rautonen, N. (2008) · Research in Microbiology · doi:10.1016/j.resmic.2008.08.002 · Cited by 111 · see citing works

Restoration of impaired intestinal barrier function by the hydrolysed casein diet contributes to the prevention of type 1 diabetes in the diabetes-prone BioBreeding rat

Visser, J. T. J., Lammers, K. M., Hoogendijk, A. J., Boer, M. W., Brugman, S., Beijer‐Liefers, S., Zandvoort, A., Harmsen, H. J. M., Welling, G. W., Stellaard, F., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1903-9 · Cited by 109 · see citing works

Phosphorylation of the tight-junction protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance

Stevenson, B. R., Anderson, J. M., Braun, I. D., & Mooseker, M. S. (1989) · Biochemical Journal · doi:10.1042/bj2630597 · Cited by 106 · see citing works

Effect of eicosapentaenoic acid (EPA) on tight junction permeability in intestinal monolayer cells

Usami, M., MURAKI, K., Iwamoto, M., Ohata, A., MATSUSHITA, E., & MIKI, A. (2001) · Clinical Nutrition · doi:10.1054/clnu.2001.0430 · Cited by 89 · see citing works

Synthesis of Isoflavone Aglycones and Equol in Soy Milks Fermented by Food-Related Lactic Acid Bacteria and Their Effect on Human Intestinal Caco-2 Cells

Cagno, R. D., Mazzacane, F., Rizzello, C. G., Vincentini, O., Silano, M., Giuliani, G., Angelis, M. D., & Gobbetti, M. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf101513r · Cited by 87 · see citing works

Effect of γ-linolenic acid or docosahexaenoic acid on tight junction permeability in intestinal monolayer cells and their mechanism by protein kinase C activation and/or eicosanoid formation

Usami, M., Komurasaki, T., Hanada, A., Kinoshita, K., & Ohata, A. (2003) · Nutrition · doi:10.1016/s0899-9007(02)00927-9 · Cited by 87 · see citing works

Green tea polyphenol (−)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-γ but not by IL-4

Watson, J. L., Ansari, S., Cameron, H. L., Wang, A., Akhtar, M., & McKay, D. M. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00302.2003 · Cited by 87 · see citing works

Hot Spices Influence Permeability of Human Intestinal Epithelial Monolayers

Jensen‐Jarolim, E., Gajdzik, L., HABERL, I., Kraft, D., Scheiner, O., & Graf, J. (1998) · Journal of Nutrition · doi:10.1093/jn/128.3.577 · Cited by 87 · see citing works

Regulation of epithelial transport and barrier function by distinct protein kinase C isoforms

Song, J. C., Hanson, C. M., Tsai, V., Farokhzad, O. C., Lotz, M. M., & Matthews, J. B. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.2.c649 · Cited by 85 · see citing works

The Role of Protein Kinase C Isoforms in Modulating Injury and Repair of the Intestinal Barrier

Farhadi, A., Keshavarzian, A., Ranjbaran, Z. S., Fields, J. Z., & Banan, A. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.085449 · Cited by 82 · see citing works

Rapid decrease in transepithelial electrical resistance of human intestinal Caco-2 cell monolayers by cytotoxic membrane perturbents

Narai, A., Arai, S., & Shimizu, M. (1997) · Toxicology in Vitro · doi:10.1016/s0887-2333(97)00026-x · Cited by 80 · see citing works

Luminal nutrients alter tight-junction permeability in the rat jejunum: an in vivo perfusion model

Sadowski, D. C., & Meddings, J. B. (1993) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y93-125 · Cited by 77 · see citing works

Surfactants Enhance the Tight-Junction Permeability of Food Allergens in Human Intestinal Epithelial Caco-2 Cells

Mine, Y., & Zhang, J. W. (2003) · International Archives of Allergy and Immunology · doi:10.1159/000069009 · Cited by 74 · see citing works

Increased Intestinal Permeability to (51 Cr) EDTA Is Correlated with IgA Immune Complex‐Plasma Levels in Children with IgA‐Associated Nephropathies

Davin, J. C., Forget, P., & Mahieu, P. R. (1988) · Acta Paediatrica · doi:10.1111/j.1651-2227.1988.tb10609.x · Cited by 68 · see citing works

Effect of capsianoside, a diterpene glycoside, on tight-junctional permeability

Hashimoto, K., Kawagishi, H., Nakayama, T., & Shimizu, M. (1997) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(96)00196-4 · Cited by 67 · see citing works

Fatty acids and epithelial permeability: effect of conjugated linoleic acid in Caco-2 cells

Roche, H. M., Terres, A. M., Black, I. B., Gibney, M. J., & Kelleher, D. (2001) · Gut · doi:10.1136/gut.48.6.797 · Cited by 67 · see citing works

Changes in Gastrointestinal Permeability in Celiac Disease

Vogelsang, H., Schwarzenhofer, M., & Oberhuber, G. (1998) · Digestive Diseases · doi:10.1159/000016886 · Cited by 62 · see citing works

The casein peptide Asn-Pro-Trp-Asp-Gln enforces the intestinal tight junction partly by increasing occludin expression in Caco-2 cells

Yasumatsu, H., & Tanabe, S. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510001698 · Cited by 61 · see citing works

Reversible Increase in Tight Junction Permeability to Macromolecules in Rat Ileal Mucosa In Vitro by Sodium Caprate, a Constituent of Milk Fat

Söderholm, J. D., Öman, H., Blomquist, L., Veen, J., Lindmark, T., & Olaison, G. (1998) · Digestive Diseases and Sciences · doi:10.1023/a:1018823100761 · Cited by 60 · see citing works

Age- and Diet-Related Increase in Transepithelial Colon Permeability of Fischer 344 Rats

Mullin, J. M., Valenzano, M. C., Verrecchio, J. J., & Kothari, R. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1020191412285 · Cited by 54 · see citing works

Increased intestinal permeability as a cause of fluctuating postprandial blood glucose levels in Type 1 diabetic patients

Damcı, T., Nuhoğlu, İ., Devranoglu, G., Oşar, Z., Demır, M., & ILKOVA, H. M. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01161.x · Cited by 51 · see citing works

Supraphysiologic L-tryptophan elicits cytoskeletal and macromolecular permeability alterations in hamster small intestinal epithelium in vitro.

Madara, J., & Carlson, S. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115017 · Cited by 48 · see citing works

Glutamine supports recovery from loss of transepithelial resistance and increase of permeability induced by media change in Caco-2 cells1

Li, N., DeMarco, V. G., West, C. M., & Neu, J. (2003) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(03)00071-8 · Cited by 46 · see citing works

Effect of Vegetable Extracts on the Transepithelial Permeability of the Human Intestinal Caco-2 Cell Monolayer

Hashimoto, K., Matsunaga, N., & Shimizu, M. (1994) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.58.1345 · Cited by 32 · see citing works

Modulations of Food-derived Substances on Intestinal Permeability in Caco-2 Cell Monolayers

KONISHI, Y. (2003) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.67.2297 · Cited by 30 · see citing works

Effects of β-Lactoglobulin on the Tight-junctional Stability of Caco-2-SF Monolayer

Hashimoto, K., Nakayama, T., & SHIMIZU, M. (1998) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.62.1819 · Cited by 22 · see citing works

Claudins in Intestinal Function and Disease

Bücker, R., Schümann, M., Amasheh, S., & Schulzke, J. (2010) · Current topics in membranes · doi:10.1016/s1063-5823(10)65009-0 · Cited by 16 · see citing works

Paracellular Transport of Water and Carbohydrates During Intestinal Perfusion of Protamine in the Rat

Shi, X., & GISOLFI, C. V. (1996) · The American Journal of the Medical Sciences · doi:10.1016/s0002-9629(15)41657-x · Cited by 11 · see citing works

Probiotic inhibition of the entry of enteroinvasive E. coli into, human intestinal epithelial cells involves both Rho-dependent and -independent pathways

Trivedi, K., Barrett, K. E., & Resta-Lenert Silvia, C. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)80524-3 · Cited by 10 · see citing works

Intestinal permeability – a new target for disease prevention and therapy

Bischoff, S. C., Barbara, G., Buurman, W., Ockhuizen, T., Schulzke, J.-D., Serino, M., Tilg, H., Watson, A., & Wells, J. M. (2014) · BMC Gastroenterology · doi:10.1186/s12876-014-0189-7 · Cited by 1,755 · see citing works

An insight into gut microbiota and its functionalities

Adak, A., & Khan, M. R. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2943-4 · Cited by 1,485 · see citing works

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., & Hyland, N. P. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00392 · Cited by 1,110 · see citing works

Impacts of gut bacteria on human health and diseases

Zhang, Y.-J., Li, S., Gan, R.-Y., Zhou, T., Xu, D.-P., & Li, H.-B. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16047493 · Cited by 1,055 · see citing works

The gut microbiota and the brain–gut–kidney axis in hypertension and chronic kidney disease

Yang, T., Richards, E. M., Pepine, C. J., & Raizada, M. K. (2018) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0018-2 · Cited by 753 · see citing works

Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa

Bron, P. A., van Baarlen, P., & Kleerebezem, M. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2690 · Cited by 690 · see citing works

Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics

Li, J.-Y., Chassaing, B., Tyagi, A. M., Vaccaro, C., Luo, T., Adams, J., Darby, T. M., Weitzmann, M. N., Mulle, J. G., Gewirtz, A. T., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86062 · Cited by 643 · see citing works

Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives

Dempsey, E., & Corr, S. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.840245 · Cited by 579 · see citing works

Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions

Mohammad, S., & Thiemermann, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594150 · Cited by 585 · see citing works

Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

Landy, J., Ronde, E., English, N., Clark, S. K., Hart, A. L., Knight, S. C., Ciclitira, P. J., & Al-Hassi, H. O. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i11.3117 · Cited by 507 · see citing works

Sleep, circadian rhythm, and gut microbiota

Matenchuk, B. A., Mandhane, P. J., & Kozyrskyj, A. L. (2020) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101340 · Cited by 495 · see citing works

Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease

Lerner, A., & Matthias, T. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.01.009 · Cited by 475 · see citing works

Translocation and dissemination of commensal bacteria in post-stroke infection

Stanley, D., Mason, L. J., Mackin, K. E., Srikhanta, Y. N., Lyras, D., Prakash, M. D., Nurgali, K., Venegas, A., Hill, M. D., Moore, R. J., et al. (2016) · Nature Medicine · doi:10.1038/nm.4194 · Cited by 464 · see citing works

The Gut Microbiota and Autism Spectrum Disorders

Li, Q., Han, Y., Dy, A. B. C., & Hagerman, R. J. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00120 · Cited by 462 · see citing works

Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; a randomized, double-blinded, placebo-controlled trial

Lamprecht, M., Bogner, S., Schippinger, G., Steinbauer, K., Fankhauser, F., Hallstroem, S., Schuetz, B., & Greilberger, J. F. (2012) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-9-45 · Cited by 257 · see citing works

Methods to determine intestinal permeability and bacterial translocation during liver disease

Wang, L., Llorente, C., Hartmann, P., Yang, A.-M., Chen, P., & Schnabl, B. (2015) · Journal of Immunological Methods · doi:10.1016/j.jim.2014.12.015 · Cited by 257 · see citing works

The intestinal microbiome, probiotics and prebiotics in neurogastroenterology

Saulnier, D. M., Ringel, Y., Heyman, M. B., Foster, J. A., Bercik, P., Shulman, R. J., Versalovic, J., Verdu, E. F., Dinan, T. G., Hecht, G., et al. (2013) · Gut Microbes · doi:10.4161/gmic.22973 · Cited by 248 · see citing works

Nutritional Keys for Intestinal Barrier Modulation

De Santis, S., Cavalcanti, E., Mastronardi, M., Jirillo, E., & Chieppa, M. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00612 · Cited by 232 · see citing works

Human gut symbiont roseburia hominis promotes and regulates innate immunity

Patterson, A. M., Mulder, I. E., Travis, A. J., Lan, A., Cerf-Bensussan, N., Gaboriau-Routhiau, V., Garden, K., Logan, E., Delday, M. I., Coutts, A. G. P., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01166 · Cited by 192 · see citing works

Impact of Probiotics on Colonizing Microbiota of the Gut

Sanders, M. E. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318227414a · Cited by 153 · see citing works

Diet, gut microbiota and cognition

Proctor, C., Thiennimitr, P., Chattipakorn, N., & Chattipakorn, S. C. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-016-9917-8 · Cited by 144 · see citing works

Overview of anti-inflammatory diets and their promising effects on non-communicable diseases

Yu, X., Pu, H., & Voss, M. (2024) · British Journal of Nutrition · doi:10.1017/s0007114524001405 · Cited by 134 · see citing works

Modulation of gastrointestinal barrier and nutrient transport function in farm animals by natural plant bioactive compounds–a comprehensive review

Patra, A. K., Amasheh, S., & Aschenbach, J. R. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1486284 · Cited by 130 · see citing works

Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome

Ringel, Y., & Maharshak, N. (2013) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00207.2012 · Cited by 115 · see citing works

From osteoimmunology to osteomicrobiology: How the microbiota and the immune system regulate bone

Hsu, E., & Pacifici, R. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0321-0 · Cited by 106 · see citing works

Increased intestinal permeability and gut dysbiosis in the R6/2 mouse model of Huntington’s disease

Stan, T. L., Soylu-Kucharz, R., Burleigh, S., Prykhodko, O., Cao, L., Franke, N., Sjögren, M., Haikal, C., Hållenius, F., & Björkqvist, M. (2020) · Scientific Reports · doi:10.1038/s41598-020-75229-9 · Cited by 101 · see citing works

Bone Remodeling and the Microbiome

Pacifici, R. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031203 · Cited by 101 · see citing works

An Exploratory Investigation of Endotoxin Levels in Novice Long Distance Triathletes, and the Effects of a Multi-Strain Probiotic/Prebiotic, Antioxidant Intervention

Roberts, J., Suckling, C., Peedle, G., Murphy, J., Dawkins, T., & Roberts, M. (2016) · Nutrients · doi:10.3390/nu8110733 · Cited by 99 · see citing works

Microbiota, a key player in alcoholic liver disease

Cassard, A.-M., & Ciocan, D. (2018) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2017.0067 · Cited by 100 · see citing works

Intestinal Barrier Dysfunction and Microbiota–Gut–Brain Axis: Possible Implications in the Pathogenesis and Treatment of Autism Spectrum Disorder

Dargenio, V. N., Dargenio, C., Castellaneta, S., De Giacomo, A., Laguardia, M., Schettini, F., Francavilla, R., & Cristofori, F. (2023) · Nutrients · doi:10.3390/nu15071620 · Cited by 98 · see citing works

“ <i>Candida Albicans</i> Interactions With The Host: Crossing The Intestinal Epithelial Barrier”

Basmaciyan, L., Bon, F., Paradis, T., Lapaquette, P., & Dalle, F. (2019) · Tissue Barriers · doi:10.1080/21688370.2019.1612661 · Cited by 89 · see citing works

The effects of a multispecies probiotic on migraine and markers of intestinal permeability – results of a randomized placebo-controlled study

de Roos, N. M., van Hemert, S., Rovers, J. M. P., Smits, M. G., & Witteman, B. J. M. (2017) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2017.57 · Cited by 89 · see citing works

Navy and black bean supplementation primes the colonic mucosal microenvironment to improve gut health

Monk, J. M., Lepp, D., Wu, W., Pauls, K. P., Robinson, L. E., & Power, K. A. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2017.08.002 · Cited by 85 · see citing works

Gut–Brain Axis in Regulation of Blood Pressure

Yang, T., & Zubcevic, J. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00845 · Cited by 74 · see citing works

The microbiome and disorders of the central nervous system

Felice, V. D., & O'Mahony, S. M. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.06.016 · Cited by 60 · see citing works

Gut Microbiota and Type 1 Diabetes Mellitus: The Effect of Mediterranean Diet

Calabrese, C. M., Valentini, A., & Calabrese, G. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.612773 · Cited by 58 · see citing works

Changes to the Intestinal Microbiome With Parenteral Nutrition: Review of a Murine Model and Potential Clinical Implications

Demehri, F. R., Barrett, M., & Teitelbaum, D. H. (2015) · Nutrition in Clinical Practice · doi:10.1177/0884533615609904 · Cited by 53 · see citing works

<i>In Vitro</i>Prevention of<i>Salmonella</i>Lipopolysaccharide-Induced Damages in Epithelial Barrier Function by Various<i>Lactobacillus</i>Strains

Yeung, C.-Y., Chiang Chiau, J.-S., Chan, W.-T., Jiang, C.-B., Cheng, M.-L., Liu, H.-L., & Lee, H.-C. (2013) · Gastroenterology Research and Practice · doi:10.1155/2013/973209 · Cited by 49 · see citing works

Inflammaging and the Lung

Kovacs, E. J., Boe, D. M., Boule, L. A., & Curtis, B. J. (2017) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2017.06.002 · Cited by 49 · see citing works

Influence of Dietary Patterns on Plasma Soluble CD14, a Surrogate Marker of Gut Barrier Dysfunction

Tabung, F. K., Birmann, B. M., Epstein, M. M., Martínez-Maza, O., Breen, E. C., Wu, K., & Giovannucci, E. L. (2017) · Current Developments in Nutrition · doi:10.3945/cdn.117.001396 · Cited by 41 · see citing works

Chemical composition and protective effect of guava ( <i>Psidium guajava</i> <scp>L.</scp> ) leaf extract on piglet intestines

Wang, D., Zhou, L., Zhou, H., Hu, H., & Hou, G. (2021) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.10904 · Cited by 33 · see citing works

Intercellular junctional complexes of the rat seminiferous tubules: A freeze‐fracture study

McGinley, D. M., Pósalaky, Z., & Porvaznik, M. (1977) · The Anatomical Record · doi:10.1002/ar.1091890208 · Cited by 42 · see citing works

Intercellular Junctions Between Human Odontoblasts

Callé, A. (1985) · Cells Tissues Organs · doi:10.1159/000145995 · Cited by 29 · see citing works

136 Intestinal Barrier Function: Physiological Regulation, Injury, and Repair in Horses and Swine

Blikslager, A. T. (2022) · Journal of Animal Science · doi:10.1093/jas/skac247.125 · Cited by 1 · see citing works

Epithelial Barrier Function

Wu, N., Yim, H. C. H., Grimm, M., & El-Omar, E. M. (2019) · Encyclopedia of Gastroenterology · doi:10.1016/b978-0-12-801238-3.65657-x · Cited by 3 · see citing works

CDT of Clostridioides difficile Induces MLC-Dependent Intestinal Barrier Dysfunction in HT-29/B6 Epithelial Cell Monolayers

Heils, L., Schneemann, M., Gerhard, R., et al. (2023) · Toxins · doi:10.3390/toxins15010054 · Cited by 7 · see citing works