Transmembrane proteins of tight junctions

JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA

Farquhar, M. G., & Palade, G. E. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.2.375 · Cited by 3,637 · see citing works

Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?

Peinado, H., Olmeda, D., & Cano, A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2131 · Cited by 3,121 · see citing works

The blood-brain barrier/neurovascular unit in health and disease

Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661 · see citing works

Occludin: a novel integral membrane protein localizing at tight junctions.

Furuse, M., Hirase, T., Itoh, M., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1993) · The Journal of cell biology · doi:10.1083/jcb.123.6.1777 · Cited by 2,580 · see citing works

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554 · see citing works

Multifunctional strands in tight junctions

Tsukita, S., Furuse, M., & Itoh, M. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35067088 · Cited by 2,514 · see citing works

Claudin-1 and -2: Novel Integral Membrane Proteins Localizing at Tight Junctions with No Sequence Similarity to Occludin

Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.7.1539 · Cited by 2,100 · see citing works

Size-selective loosening of the blood-brain barrier in claudin-5–deficient mice

Nitta, T., Hata, M., Gotoh, S., Seo, Y., Sasaki, H., Hashimoto, N., Furuse, M., & Tsukita, S. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200302070 · Cited by 1,917 · see citing works

The tight junction: a multifunctional complex

Schneeberger, E. E., & Lynch, R. D. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00558.2003 · Cited by 1,401 · see citing works

Junctional Adhesion Molecule, a Novel Member of the Immunoglobulin Superfamily That Distributes at Intercellular Junctions and Modulates Monocyte Transmigration

Martín-Padura, I., Lostaglio, S., Schneemann, M., Williams, L., Romano, M., Fruscella, P., Panzeri, C., Stoppacciaro, A., Ruco, L., Villa, A., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.117 · Cited by 1,387 · see citing works

Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry

Evans, M. J., von Hahn, T., Tscherne, D. M., Syder, A. J., Panis, M., Wölk, B., Hatziioannou, T., McKeating, J. A., Bieniasz, P. D., & Rice, C. M. (2007) · Nature · doi:10.1038/nature05654 · Cited by 1,233 · see citing works

Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands

Saitou, M., Furuse, M., Sasaki, H., Schulzke, J.-D., Fromm, M., Takano, H., Noda, T., & Tsukita, S. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.12.4131 · Cited by 1,195 · see citing works

Endothelial cell–cell junctions: happy together

Dejana, E. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1357 · Cited by 1,184 · see citing works

Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins

Itoh, M., Furuse, M., Morita, K., Kubota, K., Saitou, M., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.6.1351 · Cited by 1,151 · see citing works

Paracellin-1, a Renal Tight Junction Protein Required for Paracellular Mg 2+ Resorption

Simon, D. B., Lu, Y., Choate, K. A., Velázquez, H., Al-Sabban, E. A., Praga, M., Casari, G., Bettinelli, A., Colussi, G., Rodríguez‐Soriano, J., et al. (1999) · Science · doi:10.1126/science.285.5424.103 · Cited by 1,136 · see citing works

CLAUDINS AND EPITHELIAL PARACELLULAR TRANSPORT

Itallie, C. M. V., & Anderson, J. M. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.131404 · Cited by 1,123 · see citing works

A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

Furuse, M., Sasaki, H., Fujimoto, K., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.2.391 · Cited by 969 · see citing works

Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions.

Furuse, M., Itoh, M., Hirase, T., Nagafuchi, A., Yonemura, S., Tsukita, S., & Tsukita, S. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.6.1617 · Cited by 965 · see citing works

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein.

Balda, M. S., Whitney, J. A., Flores, C., González, S., Cereijido, M., & Matter, K. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.134.4.1031 · Cited by 876 · see citing works

Endothelial Claudin

Morita, K., Sasaki, H., Furuse, M., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.185 · Cited by 866 · see citing works

ZO-1 and ZO-2 Independently Determine Where Claudins Are Polymerized in Tight-Junction Strand Formation

Umeda, K., Ikenouchi, J., Katahira-Tayama, S., Furuse, K., Sasaki, H., Nakayama, M., Matsui, T., Tsukita, S., Furuse, M., & Tsukita, S. (2006) · Cell · doi:10.1016/j.cell.2006.06.043 · Cited by 825 · see citing works

Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells

Amasheh, S., Meiri, N., Gitter, A. H., Schöneberg, T., Mankertz, J., Schulzke, J. D., & Fromm, M. (2002) · Journal of Cell Science · doi:10.1242/jcs.00165 · Cited by 812 · see citing works

Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells

Ikenouchi, J., Furuse, M., Furuse, K., Sasaki, H., Tsukita, S., & Tsukita, S. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200510043 · Cited by 787 · see citing works

High-Throughput Mapping of a Dynamic Signaling Network in Mammalian Cells

Barrios‐Rodiles, M., Brown, K. R., Ozdamar, B., Bose, R., Liu, Z., Donovan, R. S., Shinjo, F., Liu, Y., Dembowy, J., Taylor, I. W., et al. (2005) · Science · doi:10.1126/science.1105776 · Cited by 726 · see citing works

Conversion of Zonulae Occludentes from Tight to Leaky Strand Type by Introducing Claudin-2 into Madin-Darby Canine Kidney I Cells

Furuse, M., Furuse, K., Sasaki, H., & Tsukita, S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.2.263 · Cited by 719 · see citing works

The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction

Cohen, C. J., Shieh, J. T. C., Pickles, R. J., Okegawa, T., Hsieh, J., & Bergelson, J. M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261452898 · Cited by 702 · see citing works

Regulation of tight junctions during the epithelium-mesenchyme transition:direct repression of the gene expression of claudins/occludin by Snail

Ikenouchi, J., Matsuda, M., Furuse, M., & Tsukita, S. (2003) · Journal of Cell Science · doi:10.1242/jcs.00389 · Cited by 678 · see citing works

Junction Adhesion Molecule Is a Receptor for Reovirus

Barton, E. S., Forrest, J. C., Connolly, J. L., Chappell, J. D., Liu, Y., Schnell, F. J., Nusrat, A., Parkos, C. A., & Dermody, T. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00231-8 · Cited by 627 · see citing works

Clostridium perfringens Enterotoxin Fragment Removes Specific Claudins from Tight Junction Strands

Sonoda, N., Furuse, M., Sasaki, H., Yonemura, S., Katahira, J., Horiguchi, Y., & Tsukita, S. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.1.195 · Cited by 612 · see citing works

Regulated expression of claudin-4 decreases paracellular conductance through a selective decrease in sodium permeability

Itallie, C. M. V., Rahner, C., & Anderson, J. M. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12464 · Cited by 601 · see citing works

Hepatocyte nuclear factor 4α controls the development of a hepatic epithelium and liver morphogenesis

Parviz, F., Matullo, C., Garrison, W. D., Savatski, L., Adamson, J. W., Ning, G., Kaestner, K. H., Rossi, J. M., Zaret, K. S., & Duncan, S. A. (2003) · Nature Genetics · doi:10.1038/ng1175 · Cited by 588 · see citing works

Claudin Proteins in Human Cancer: Promising New Targets for Diagnosis and Therapy

Morin, P. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2782 · Cited by 576 · see citing works

Occludin-deficient Embryonic Stem Cells Can Differentiate into Polarized Epithelial Cells Bearing Tight Junctions

Saitou, M., Fujimoto, K., Doi, Y., Itoh, M., Fujimoto, T., Furuse, M., Takano, H., Noda, T., & Tsukita, S. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.2.397 · Cited by 548 · see citing works

Virus-Induced Abl and Fyn Kinase Signals Permit Coxsackievirus Entry through Epithelial Tight Junctions

Coyne, C. B., & Bergelson, J. M. (2006) · Cell · doi:10.1016/j.cell.2005.10.035 · Cited by 547 · see citing works

Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut

Rahner, C., Mitic, L. L., & Anderson, J. M. (2001) · Gastroenterology · doi:10.1053/gast.2001.21736 · Cited by 546 · see citing works

Claudins create charge-selective channels in the paracellular pathway between epithelial cells

Colegio, O. R., Itallie, C. M. V., McCrea, H. J., Rahner, C., & Anderson, J. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00038.2002 · Cited by 545 · see citing works

A Synthetic Peptide Corresponding to the Extracellular Domain of Occludin Perturbs the Tight Junction Permeability Barrier

Wong, V., & Gumbiner, B. M. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.2.399 · Cited by 540 · see citing works

Claudins in occluding junctions of humans and flies

Furuse, M., & Tsukita, S. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.02.006 · Cited by 525 · see citing works

Mutations in the Tight-Junction Gene Claudin 19 (CLDN19) Are Associated with Renal Magnesium Wasting, Renal Failure, and Severe Ocular Involvement

Konrad, M., Schaller, A., Seelow, D., Pandey, A. V., Waldegger, S., Lesslauer, A., Vitzthum, H., Suzuki, Y., Luk, J. M., Becker, C., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/508617 · Cited by 525 · see citing works

Human junction adhesion molecule regulates tight junction resealing in epithelia

Liu, Y., Nusrat, A., Schnell, F. J., Reaves, T. A., Walsh, S. V., Pochet, M., & Parkos, C. A. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.13.2363 · Cited by 525 · see citing works

Further observations on the fine structure of freeze-cleaved tight junctions

Staehelin, L. A. (1973) · Journal of Cell Science · doi:10.1242/jcs.13.3.763 · Cited by 512 · see citing works

The role of junctional adhesion molecules in vascular inflammation

Weber, C., Fraemohs, L., & Dejana, E. (2007) · Nature reviews. Immunology · doi:10.1038/nri2096 · Cited by 504 · see citing works

Junctional adhesion molecules (JAMs): more molecules with dual functions?

Ebnet, K., Suzuki, A., Ohno, S., & Vestweber, D. (2003) · Journal of Cell Science · doi:10.1242/jcs.00930 · Cited by 501 · see citing works

The claudin gene family: expression in normal and neoplastic tissues

Hewitt, K. J., Agarwal, R., & Morin, P. J. (2006) · BMC Cancer · doi:10.1186/1471-2407-6-186 · Cited by 498 · see citing works

Differential Expression Patterns of Claudins, Tight Junction Membrane Proteins, in Mouse Nephron Segments

西信, 裕., Gotoh, S., Furuse, M., Takasuga, A., Tano, Y., & Tsukita, S. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v134875 · Cited by 475 · see citing works

Claudins regulate the intestinal barrier in response to immune mediators

Kinugasa, T., Sakaguchi, T., Gu, X., & Reinecker, H. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70351-9 · Cited by 463 · see citing works

Mutations in the Gene Encoding Tight Junction Claudin-14 Cause Autosomal Recessive Deafness DFNB29

Wilcox, E. R., Burton, Q., Naz, S., Riazuddin, S., Smith, T. N., Ploplis, B., Belyantseva, I. A., Ben‐Yosef, T., Liburd, N., Morell, R. J., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00200-8 · Cited by 442 · see citing works

Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: A tight junction disease

Hadj-Rabia, S., Baala, L., Vabres, P., Hamel‐Teillac, D., Jacquemin, E., Fabrè, M., Lyonnet, S., Prost, Y. D., Münnich, A., Hadchouel, M., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.07.022 · Cited by 426 · see citing works

Androgens regulate the permeability of the blood–testis barrier

Meng, J., Holdcraft, R. W., Shima, J. E., Griswold, M. D., & Braun, R. E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506084102 · Cited by 397 · see citing works

Barriers built on claudins

Turksen, K., & Troy, T. (2004) · Journal of Cell Science · doi:10.1242/jcs.01235 · Cited by 397 · see citing works

The cell polarity protein ASIP/PAR‐3 directly associates with junctional adhesion molecule (JAM)

Ebnet, K., Suzuki, A., Horikoshi, Y., Hirose, T., zu Brickwedde, M. M., Ohno, S., & Vestweber, D. (2001) · The EMBO Journal · doi:10.1093/emboj/20.14.3738 · Cited by 394 · see citing works

Adenovirus Fiber Disrupts CAR-Mediated Intercellular Adhesion Allowing Virus Escape

Walters, R. W., Freimuth, P., Moninger, T. O., Ganske, I. M., Zabner, J., & Welsh, M. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00912-1 · Cited by 392 · see citing works

Junctional adhesion molecule (JAM) binds to PAR-3

Itoh, M., Sasaki, H., Furuse, M., Ozaki, H., Kita, T., & Tsukita, S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200103047 · Cited by 385 · see citing works

Claudin-3 and Claudin-4 Expression in Ovarian Epithelial Cells Enhances Invasion and Is Associated with Increased Matrix Metalloproteinase-2 Activity

Agarwal, R., D’Souza, T., & Morin, P. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1036 · Cited by 374 · see citing works

Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins

Itallie, C. M. V., Fanning, A. S., & Anderson, J. M. (2003) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00116.2003 · Cited by 372 · see citing works

Multi-PDZ Domain Protein 1 (MUPP1) Is Concentrated at Tight Junctions through Its Possible Interaction with Claudin-1 and Junctional Adhesion Molecule

Hamazaki, Y., Itoh, M., Sasaki, H., Furuse, M., & Tsukita, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109005200 · Cited by 366 · see citing works

Tight junctions and human diseases

Sawada, N., Murata, M., Kikuchi, K., Osanai, M., Tobioka, H., Kojima, T., & Chiba, H. (2003) · Medical Molecular Morphology · doi:10.1007/s00795-003-0219-y · Cited by 348 · see citing works

Mechanism of IFN-γ-induced Endocytosis of Tight Junction Proteins: Myosin II-dependent Vacuolarization of the Apical Plasma Membrane

Utech, M., Ivanov, A. I., Samarin, S., Bruewer, M., Turner, J. R., Mrsny, R. J., Parkos, C. A., & Nusrat, A. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-03-0193 · Cited by 347 · see citing works

Claudin 14 knockout mice, a model for autosomal recessive deafness DFNB29, are deaf due to cochlear hair cell degeneration

Ben‐Yosef, T. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg210 · Cited by 339 · see citing works

The JAM family of junctional adhesion molecules

Bazzoni, G. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00104-2 · Cited by 327 · see citing works

The transcription factor Snail downregulates the tight junction components independently of E-cadherin downregulation

Ohkubo, T., & Ozawa, M. (2004) · Journal of Cell Science · doi:10.1242/jcs.01004 · Cited by 322 · see citing works

Mammalian tight junctions in the regulation of epithelial differentiation and proliferation

Matter, K., Aijaz, S., Tsapara, A., & Balda, M. S. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.08.003 · Cited by 313 · see citing works

Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications

Mankertz, J., & Schulzke, J.-D. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32816aa392 · Cited by 312 · see citing works

Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells

Yu, A. S. L., McCarthy, K. M., Francis, S. A., McCormack, J. M., Lai, J., Rogers, R. A., Lynch, R. D., & Schneeberger, E. E. (2005) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00581.2004 · Cited by 307 · see citing works

COOH Terminus of Occludin Is Required for Tight Junction Barrier Function in Early Xenopus Embryos

Chen, Y., Merzdorf, C., Paul, D. L., & Goodenough, D. A. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.4.891 · Cited by 302 · see citing works

The Molecular Physiology of Tight Junction Pores

Itallie, C. M. V., & Anderson, J. M. (2004) · Physiology · doi:10.1152/physiol.00027.2004 · Cited by 298 · see citing works

Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patterns.

Holmes, J. L., Itallie, C. V. V., Rasmussen, J. E., & Anderson, J. (2006) · Gene Expression Patterns · doi:10.1016/j.modgep.2005.12.001 · Cited by 297 · see citing works

Role of claudin interactions in airway tight junctional permeability

Coyne, C. B., Gambling, T. M., Boucher, R. C., Carson, J. L., & Johnson, L. G. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00182.2003 · Cited by 291 · see citing works

The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer

Pálmer, H. G., Larriba, M. J., García, J. M., Ordóñez‐Morán, P., Peña, C., Peiró, S., Puig, I., Rodríguez, R., de la Fuente, R., Bernad, A., et al. (2004) · Nature Medicine · doi:10.1038/nm1095 · Cited by 286 · see citing works

Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin‐3, a tight junction integral membrane protein

Fujita, K., Katahira, J., Horiguchi, Y., et al. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01744-0 · Cited by 283 · see citing works

Tricellulin is a tight-junction protein necessary for hearing

Riazuddin, S., Ahmed, Z. M., Fanning, A. S., Lagziel, A., Kitajiri, S.-I., Ramzan, K., Khan, S. N., Chattaraj, P., Friedman, P. L., Anderson, J. M., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/510022 · Cited by 283 · see citing works

The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity

Ebnet, K., Aurrand‐Lions, M., Kuhn, A., Kiefer, F., Butz, S., Zander, K., zu Brickwedde, M.-K. M., Suzuki, A., Imhof, B. A., & Vestweber, D. (2003) · Journal of Cell Science · doi:10.1242/jcs.00704 · Cited by 280 · see citing works

Molecular Cloning and Functional Characterization of the Receptor for Clostridium perfringens Enterotoxin

Katahira, J., Inoue, N., Horiguchi, Y., Matsuda, M., & Sugimoto, N. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.6.1239 · Cited by 278 · see citing works

Novel Paracellin-1 Mutations in 25 Families with Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis

Weber, S., Schneider, L. H., Peters, M. M. C. G., et al. (2001) · Journal of the American Society of Nephrology · doi:10.1681/asn.v1291872 · Cited by 278 · see citing works

Claudin-8 Expression in Madin-Darby Canine Kidney Cells Augments the Paracellular Barrier to Cation Permeation

Yu, A. S. L., Enck, A. H., Lencer, W. I., & Schneeberger, E. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213286200 · Cited by 273 · see citing works

Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins

Yamauchi, K., Rai, T., Kobayashi, K., Sohara, E., Suzuki, T., Itoh, T., Suda, S., Hayama, A., Sasaki, S., & Uchida, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306924101 · Cited by 270 · see citing works

Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex

Nunbhakdi‐Craig, V., Machleidt, T., Ogris, E., Bellotto, D. J., White, C. L., & Sontag, E. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200206114 · Cited by 266 · see citing works

Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells

Nagasawa, K., Chiba, H., Fujita, H., Kojima, T., Saito, T., Endo, T., & Sawada, N. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20647 · Cited by 255 · see citing works

ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability

Wegmann, F., Petri, B., Khandoga, A. G., Moser, C., Khandoga, A., Volkery, S., Li, H., Nasdala, I., Brandau, O., Fässler, R., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060565 · Cited by 249 · see citing works

Hepatocyte nuclear factor 4α orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver

Battle, M. A., Konopka, G., Parviz, F., Gaggl, A. L., Yang, C., Sladek, F. M., & Duncan, S. A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600246103 · Cited by 246 · see citing works

Differential Expression and Subcellular Localization of Claudin-7, −8, −12, −13, and −15 Along the Mouse Intestine

Fujita, H., Chiba, H., Yokozaki, H., Sakai, N., Sugimoto, K., Wada, T., Kojima, T., Yamashita, T., & Sawada, N. (2006) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.6a6944.2006 · Cited by 242 · see citing works

Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C

Gliki, G., Ebnet, K., Aurrand‐Lions, M., Imhof, B. A., & Adams, R. H. (2004) · Nature · doi:10.1038/nature02877 · Cited by 241 · see citing works

Hypoxia Disrupts the Barrier Function of Neural Blood Vessels through Changes in the Expression of Claudin-5 in Endothelial Cells

Koto, T., Takubo, K., Ishida, S., Shinoda, H., Inoue, M., Tsubota, K., Okada, Y., & Ikeda, E. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.060693 · Cited by 238 · see citing works

Oncogenic Raf-1 Disrupts Epithelial Tight Junctions via Downregulation of Occludin

Li, D., & Mrsny, R. J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.4.791 · Cited by 233 · see citing works

Paracellin-1 and the modulation of ion selectivity of tight junctions

Hou, J., Paul, D. L., & Goodenough, D. A. (2005) · Journal of Cell Science · doi:10.1242/jcs.02631 · Cited by 232 · see citing works

Permeability barrier dysfunction in transgenic mice overexpressing claudin 6

Turksen, K., & Troy, T.-C. (2002) · Development · doi:10.1242/dev.129.7.1775 · Cited by 230 · see citing works

Tight Junction Protein Claudin-1 Enhances the Invasive Activity of Oral Squamous Cell Carcinoma Cells by Promoting Cleavage of Laminin-5 γ2 Chain via Matrix Metalloproteinase (MMP)-2 and Membrane-Type MMP-1

Oku, N., Sasabe, E., Ueta, E., Yamamoto, T., & Osaki, T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4478 · Cited by 222 · see citing works

Phosphorylation of Claudin-3 at Threonine 192 by cAMP-dependent Protein Kinase Regulates Tight Junction Barrier Function in Ovarian Cancer Cells

D’Souza, T., Agarwal, R., & Morin, P. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502003200 · Cited by 220 · see citing works

A Transmembrane Tight Junction Protein Selectively Expressed on Endothelial Cells and Platelets

Nasdala, I., Wolburg‐Buchholz, K., Wolburg, H., Kuhn, A., Ebnet, K., Brachtendorf, G., Samulowitz, U., Küster, B., Engelhardt, B., Vestweber, D., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111999200 · Cited by 217 · see citing works

Alveolar Epithelial Cells Direct Monocyte Transepithelial Migration upon Influenza Virus Infection: Impact of Chemokines and Adhesion Molecules

Herold, S., von Wulffen, W., Steinmueller, M., Pleschka, S., Kuziel, W. A., Mack, M., Srivastava, M., Seeger, W., Maus, U. A., & Lohmeyer, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1817 · Cited by 216 · see citing works

Cyclic AMP induces phosphorylation of claudin-5 immunoprecipitates and expression of claudin-5 gene in blood–brain-barrier endothelial cells via protein kinase A-dependent and -independent pathways

Ishizaki, T., Chiba, H., Kojima, T., Fujibe, M., Soma, T., Miyajima, H., Nagasawa, K., Wada, I., & Sawada, N. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00354-9 · Cited by 205 · see citing works

Overexpression of claudin-7 decreases the paracellular Cl– conductance and increases the paracellular Na+ conductance in LLC-PK1 cells

Alexandre, M. D., Lu, Q., & Chen, Y. (2005) · Journal of Cell Science · doi:10.1242/jcs.02406 · Cited by 203 · see citing works

Ca2+-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions

Kubota, K., Furuse, M., Sasaki, H., Sonoda, N., Fujita, K., Nagafuchi, A., & Tsukita, S. (1999) · Current Biology · doi:10.1016/s0960-9822(99)80452-7 · Cited by 201 · see citing works

Disease-associated mutations affect intracellular traffic and paracellular Mg2+ transport function of Claudin-16

Kausalya, P. J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26323 · Cited by 201 · see citing works

EphA2 Phosphorylates the Cytoplasmic Tail of Claudin-4 and Mediates Paracellular Permeability

Tanaka, M., Kamata, R., & Sakai, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503786200 · Cited by 196 · see citing works

Palmitoylation of claudins is required for efficient tight-junction localization

Itallie, C. M. V., Gambling, T. M., Carson, J. L., & Anderson, J. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.01735 · Cited by 195 · see citing works

Protein Phosphatases 2A and 1 Interact with Occludin and Negatively Regulate the Assembly of Tight Junctions in the CACO-2 Cell Monolayer

Seth, A., Sheth, P., Elias, B. C., & Rao, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610597200 · Cited by 191 · see citing works

Cloning of an Immunoglobulin Family Adhesion Molecule Selectively Expressed by Endothelial Cells

Hirata, K.-I., Ishida, T., Penta, K., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100630200 · Cited by 187 · see citing works

Neutrophil Migration across Tight Junctions Is Mediated by Adhesive Interactions between Epithelial Coxsackie and Adenovirus Receptor and a Junctional Adhesion Molecule-like Protein on Neutrophils

Zen, K., Liu, Y., McCall, I. C., Wu, T., Lee, W., Babbin, B. A., Nusrat, A., & Parkos, C. A. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-01-0036 · Cited by 185 · see citing works

The Junctional Adhesion Molecule-C Promotes Neutrophil Transendothelial Migration in Vitro and in Vivo

Chavakis, T., Keiper, T., Matz, R. L., Hersemeyer, K., Sachs, U. J., Nawroth, P. P., Preissner, K. T., & Santoso, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404676200 · Cited by 184 · see citing works

JAM4, a Junctional Cell Adhesion Molecule Interacting with a Tight Junction Protein, MAGI-1

Hirabayashi, S., Tajima, M., Yao, I., Nishimura, W., Mori, H., & Hata, Y. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.12.4267-4282.2003 · Cited by 183 · see citing works

The Carboxyl Terminus of Zona Occludens-3 Binds and Recruits a Mammalian Homologue of Discs Lost to Tight Junctions

Roh, M. H., Liu, C., Laurinec, S., & Margolis, B. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201177200 · Cited by 181 · see citing works

Expression of claudin-7 and -8 along the mouse nephron

Li, W. Y., Huey, C. L., & Yu, A. S. L. (2004) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00384.2003 · Cited by 180 · see citing works

Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A–deficient mice

Cera, M. R., Prete, A. D., Vecchi, A., Corada, M., Martín-Padura, I., Motoike, T., Tonetti, P., Bazzoni, G., Vermi, W., Gentili, F., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21231 · Cited by 172 · see citing works

Expression patterns of claudins, tight junction adhesion molecules, in the inner ear

Kitajiri, S.-I., Furuse, M., Morita, K., Saishin-Kiuchi, Y., Kido, H., Ito, J., & Tsukita, S. (2003) · Hearing Research · doi:10.1016/s0378-5955(03)00338-1 · Cited by 167 · see citing works

Cloning of the Human Claudin-2 5′-Flanking Region Revealed a TATA-less Promoter with Conserved Binding Sites in Mouse and Human for Caudal-related Homeodomain Proteins and Hepatocyte Nuclear Factor-1α

Sakaguchi, T., Gu, X., Golden, H. M., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110261200 · Cited by 167 · see citing works

The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis

Raschperger, E., Thyberg, J., Pettersson, S., Philipson, L., Fuxe, J., & Pettersson, R. F. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.01.025 · Cited by 166 · see citing works

The cell–cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7

Ladwein, M., Pape, U., SCHMIDT, D., et al. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.06.013 · Cited by 164 · see citing works

Epithelial tight junctions, gene expression and nucleo-junctional interplay

Matter, K., & Balda, M. S. (2007) · Journal of Cell Science · doi:10.1242/jcs.005975 · Cited by 162 · see citing works

Nonreceptor Tyrosine Kinase c-Yes Interacts with Occludin during Tight Junction Formation in Canine Kidney Epithelial Cells

Chen, Y., Lu, Q., Goodenough, D. A., & Jeansonne, B. G. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-08-0423 · Cited by 162 · see citing works

Claudins: emerging targets for cancer therapy

Kominsky, S. L. (2006) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399406000056 · Cited by 160 · see citing works

Transgenic RNAi Depletion of Claudin-16 and the Renal Handling of Magnesium

Hou, J., Shan, Q., Wang, T., Gomes, A. S., Yan, Q., Paul, D. L., Bleich, M., & Goodenough, D. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700632200 · Cited by 159 · see citing works

Reduced expression of claudin-7 correlates with invasion and metastasis in squamous cell carcinoma of the esophagus

Usami, Y., Chiba, H., Nakayama, F., et al. (2006) · Human Pathology · doi:10.1016/j.humpath.2005.12.018 · Cited by 155 · see citing works

Endocytosis of the apical junctional complex: mechanisms and possible roles in regulation of epithelial barriers

Ivanov, A. I., Nusrat, A., & Parkos, C. A. (2005) · BioEssays · doi:10.1002/bies.20203 · Cited by 155 · see citing works

Claudins: multifunctional players in epithelial tight junctions and their role in cancer

de Oliveira, S. S., & Morgado‐Díaz, J. A. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6314-1 · Cited by 151 · see citing works

Thr203 of claudin-1, a putative phosphorylation site for MAP kinase, is required to promote the barrier function of tight junctions

Fujibe, M., Chiba, H., Kojima, T., Soma, T., Wada, T., Yamashita, T., & Sawada, N. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2003.12.014 · Cited by 148 · see citing works

Differential expression of claudin‐2 along the human intestine: Implication of GATA‐4 in the maintenance of claudin‐2 in differentiating cells

Escaffit, F., Boudreau, F., & Beaulieu, J. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20189 · Cited by 146 · see citing works

JAM-C Is a Component of Desmosomes and a Ligand for CD11b/CD18-mediated Neutrophil Transepithelial Migration

Zen, K., Babbin, B. A., Liu, Y., Whelan, J. B., Nusrat, A., & Parkos, C. A. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-04-0317 · Cited by 139 · see citing works

CLMP, a Novel Member of the CTX Family and a New Component of Epithelial Tight Junctions

Raschperger, E., Engström, U., Pettersson, R. F., & Fuxe, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308249200 · Cited by 135 · see citing works

Involvement of the Junctional Adhesion Molecule-1 (JAM1) Homodimer Interface in Regulation of Epithelial Barrier Function

Mandell, K. J., McCall, I. C., & Parkos, C. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309483200 · Cited by 134 · see citing works

Extracellular Signal-regulated Kinases 1/2 Control Claudin-2 Expression in Madin-Darby Canine Kidney Strain I and II Cells

Lipschutz, J. H., Li, S., Arisco, A. M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408122200 · Cited by 133 · see citing works

JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells

Moog‐Lutz, C., Riant, F., Guibal, F. C., et al. (2003) · Blood · doi:10.1182/blood-2002-11-3462 · Cited by 131 · see citing works

Coxsackievirus-adenovirus receptor (CAR) is essential for early embryonic cardiac development

Dorner, A. A., Wegmann, F., Butz, S., Wolburg‐Buchholz, K., Wolburg, H., Mack, A. F., Nasdala, I., August, B. K., Westermann, J., Rathjen, F. G., et al. (2005) · Journal of Cell Science · doi:10.1242/jcs.02476 · Cited by 128 · see citing works

Thr207 of claudin-5 is involved in size-selective loosening of the endothelial barrier by cyclic AMP

Soma, T., Chiba, H., Kato‐Mori, Y., Wada, T., Yamashita, T., Kojima, T., & Sawada, N. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.07.012 · Cited by 125 · see citing works

Keynote review: Epithelial and endothelial barriers in human disease

Mullin, J. M., Agostino, N. M., Rendon‐Huerta, E. P., & Thornton, J. J. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03379-9 · Cited by 124 · see citing works

Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury

Corada, M., Chimenti, S., Cera, M. R., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500147102 · Cited by 122 · see citing works

Isolation and Characterization of Transcripts Induced by Androgen Withdrawal and Apoptotic Cell Death in the Rat Ventral Prostate

Briehl, M. M., & Miesfeld, R. L. (1991) · Molecular Endocrinology · doi:10.1210/mend-5-10-1381 · Cited by 120 · see citing works

Epigenetic Silencing of Occludin Promotes Tumorigenic and Metastatic Properties of Cancer Cells via Modulations of Unique Sets of Apoptosis-Associated Genes

Osanai, M., Murata, M., Nishikiori, N., Chiba, H., Kojima, T., & Sawada, N. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1864 · Cited by 120 · see citing works

Targeted Disruption of Endothelial Cell-selective Adhesion Molecule Inhibits Angiogenic Processes in Vitro and in Vivo

Ishida, T., Kundu, R. K., Yang, E., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304890200 · Cited by 115 · see citing works

Occludin 1B, a Variant of the Tight Junction Protein Occludin

Muresan, Z. L., Paul, D. L., & Goodenough, D. A. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.2.627 · Cited by 115 · see citing works

Cingulin Regulates Claudin-2 Expression and Cell Proliferation through the Small GTPase RhoA

Guillemot, L., & Citi, S. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-02-0122 · Cited by 113 · see citing works

Crosstalk between different adhesion molecules

Chen, X., & Gumbiner, B. M. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.07.002 · Cited by 109 · see citing works

Junctional adhesion molecule-A deficiency increases hepatic ischemia-reperfusion injury despite reduction of neutrophil transendothelial migration

Khandoga, A., Kessler, J. S., Meißner, H., et al. (2005) · Blood · doi:10.1182/blood-2004-11-4416 · Cited by 108 · see citing works

Antibody against Junctional Adhesion Molecule-C Inhibits Angiogenesis and Tumor Growth

Lamagna, C., Hodivala‐Dilke, K., Imhof, B. A., & Aurrand‐Lions, M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4012 · Cited by 107 · see citing works

The C-terminal cytoplasmic tail of claudins 1 and 5 but not its PDZ-binding motif is required for apical localization at epithelial and endothelial tight junctions

Rüffer, C., & Gerke, V. (2004) · European Journal of Cell Biology · doi:10.1078/0171-9335-00366 · Cited by 106 · see citing works

Phosphorylation of paracellin-1 at Ser217 by protein kinase A is essential for localization in tight junctions

Ikari, A., Matsumoto, S., Harada, H., Takagi, K., Hayashi, H., Suzuki, Y., Degawa, M., & Miwa, M. (2006) · Journal of Cell Science · doi:10.1242/jcs.02901 · Cited by 106 · see citing works

Tight junction: a co‐ordinator of cell signalling and membrane trafficking

Köhler, K., & Zahraoui, A. (2005) · Biology of the Cell · doi:10.1042/bc20040147 · Cited by 100 · see citing works

The Coxsackievirus and Adenovirus Receptor (CAR) Forms a Complex with the PDZ Domain-containing Protein Ligand-of-Numb Protein-X (LNX)

Sollerbrant, K., Raschperger, E., Mirza, M., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m205927200 · Cited by 100 · see citing works

Retinoid X Receptor α and Retinoic Acid Receptor γ Mediate Expression of Genes Encoding Tight-Junction Proteins and Barrier Function in F9 Cells during Visceral Endodermal Differentiation

Kubota, H., Chiba, H., Takakuwa, Y., Osanai, M., Tobioka, H., KOHAMA, G.-I., Mori, M., & Sawada, N. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5113 · Cited by 97 · see citing works

Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation

Gareus, R., Huth, M., Breiden, B., Nenci, A., Rösch, N., Haase, I., Bloch, W., Sandhoff, K., & Pasparakis, M. (2007) · Nature Cell Biology · doi:10.1038/ncb1560 · Cited by 96 · see citing works

Junctional adhesion molecule-A-induced endothelial cell migration on vitronectin is integrin αvβ3 specific

Naik, M. U., & Naik, U. P. (2006) · Journal of Cell Science · doi:10.1242/jcs.02771 · Cited by 95 · see citing works

Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development

Asher, D. R., Cerny, A., Weiler, S. R., Horner, J. W., Keeler, M. L., Neptune, M. A., Jones, S. N., Bronson, R. T., DePinho, R. A., & Finberg, R. W. (2005) · genesis · doi:10.1002/gene.20127 · Cited by 92 · see citing works

The role of junctional adhesion molecule‐C (JAM‐C) in oxidized LDL‐mediated leukocyte recruitment

Keiper, T., Al‐Fakhri, N., Chavakis, E., Athanasopoulos, A. N., Isermann, B., Herzog, S., Saffrich, R., Hersemeyer, K., Bohle, R. M., Haendeler, J., et al. (2005) · The FASEB Journal · doi:10.1096/fj.05-4196fje · Cited by 92 · see citing works

Hepatocyte nuclear factor (HNF)-4α triggers formation of functional tight junctions and establishment of polarized epithelial morphology in F9 embryonal carcinoma cells

Chiba, H., Gotoh, T., Kojima, T., Satohisa, S., Kikuchi, K., Osanai, M., & Sawada, N. (2003) · Experimental Cell Research · doi:10.1016/s0014-4827(03)00116-2 · Cited by 90 · see citing works

The Homophilic Binding of Junctional Adhesion Molecule-C Mediates Tumor Cell-Endothelial Cell Interactions

Santoso, S., Orlova, V. V., Song, K., Sachs, U. J., Andrei‐Selmer, C., & Chavakis, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505059200 · Cited by 87 · see citing works

Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts

Wegmann, F., Ebnet, K., Pasquier, L. D., et al. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.07.010 · Cited by 84 · see citing works

Expression of junctional adhesion molecule-A prevents spontaneous and random motility

Bazzoni, G., Tonetti, P., Manzi, L., Cera, M. R., Balconi, G., & Dejana, E. (2005) · Journal of Cell Science · doi:10.1242/jcs.01661 · Cited by 84 · see citing works

Junctional adhesion molecule-A participates in the formation of apico-basal polarity through different domains

Rehder, D., Iden, S., Nasdala, I., Wegener, J., zu Brickwedde, M.-K. M., Vestweber, D., & Ebnet, K. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.07.004 · Cited by 83 · see citing works

Bves modulates epithelial integrity through an interaction at the tight junction

Osler, M. E., Chang, M. S., & Bader, D. M. (2005) · Journal of Cell Science · doi:10.1242/jcs.02588 · Cited by 82 · see citing works

Association of Paracellin-1 with ZO-1 Augments the Reabsorption of Divalent Cations in Renal Epithelial Cells

Ikari, A., Hirai, N., Shiroma, M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406331200 · Cited by 82 · see citing works

Glial Cell–Derived Cytokines Attenuate the Breakdown of Vascular Integrity in Diabetic Retinopathy

Nishikiori, N., Osanai, M., Chiba, H., Kojima, T., Mitamura, Y., Ohguro, H., & Sawada, N. (2007) · Diabetes · doi:10.2337/db06-1431 · Cited by 82 · see citing works

Heterogeneous Expression of Claudin-4 in Human Colorectal Cancer: Decreased Claudin-4 Expression at the Invasive Front Correlates Cancer Invasion and Metastasis

Ueda, J., Semba, S., Chiba, H., et al. (2007) · Pathobiology · doi:10.1159/000101049 · Cited by 80 · see citing works

The second loop of occludin is required for suppression of Raf1-induced tumor growth

Wang, Z., Mandell, K. J., Parkos, C. A., et al. (2005) · Oncogene · doi:10.1038/sj.onc.1208634 · Cited by 76 · see citing works

Snail controls differentiation of hepatocytes by repressing HNF4α expression

Cicchini, C., Filippini, D., Coen, S., Marchetti, A., Cavallari, C., Laudadio, I., Spagnoli, F. M., Alonzi, T., & Tripodi, M. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20730 · Cited by 75 · see citing works

Characteristics of Claudin Expression in Follicle-Associated Epithelium of Peyer's Patches: Preferential Localization of Claudin-4 at the Apex of the Dome Region

Tamagawa, H., Takahashi, I., Furuse, M., Yoshitake-Kitano, Y., Tsukita, S., Ito, T., Matsuda, H., & Kiyono, H. (2003) · Laboratory Investigation · doi:10.1097/01.lab.0000078741.55670.6e · Cited by 67 · see citing works

Delayed epidermal permeability barrier formation and hair follicle aberrations in Inv-Cldn6 mice

Troy, T., Rahbar, R., Arabzadeh, A., Cheung, R. M.-K., & Turksen, K. (2005) · Mechanisms of Development · doi:10.1016/j.mod.2005.03.001 · Cited by 66 · see citing works

Heterogeneity in expression and subcellular localization of tight junction proteins, claudin-10 and -15, examined by RT-PCR and immunofluorescence microscopy

Inai, T., Sengoku, A., Guan, X., Hirose, E., Iida, H., & Shibata, Y. (2005) · Archivum histologicum japonicum · doi:10.1679/aohc.68.349 · Cited by 66 · see citing works

Behavior of tight-junction, adherens-junction and cell polarity proteins during HNF-4α-induced epithelial polarization

Satohisa, S., Chiba, H., Osanai, M., et al. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.06.025 · Cited by 60 · see citing works

Familial hypomagnesemia with hypercalciuria and nephrocalcinosis: blocking endocytosis restores surface expression of a novel Claudin-16 mutant that lacks the entire C-terminal cytosolic tail

Müller, D., Kausalya, P. J., Meij, I. C., & Hunziker, W. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl020 · Cited by 59 · see citing works

Down-regulation of survival signaling through MAPK and Akt in occludin-deficient mouse hepatocytes in vitro

Murata, M., Kojima, T., Yamamoto, T., Go, M., Takano, K., Osanai, M., Chiba, H., & Sawada, N. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.07.017 · Cited by 55 · see citing works

Role of the Cldn6 Cytoplasmic Tail Domain in Membrane Targeting and Epidermal Differentiation In Vivo

Arabzadeh, A., Troy, T., & Turksen, K. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02342-05 · Cited by 54 · see citing works

Isoform-specific expression of the Coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discs

Shaw, C. A., Holland, P. C., Sinnreich, M., Allen, C. A., Sollerbrant, K., Karpati, G., & Nalbantoglu, J. N. (2004) · BMC Cell Biology · doi:10.1186/1471-2121-5-42 · Cited by 53 · see citing works

Junctional Adhesion Molecule-C Promotes Metastatic Potential of HT1080 Human Fibrosarcoma

Fuse, C., Ishida, Y., Hikita, T., Asai, T., & Oku, N. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608836200 · Cited by 52 · see citing works

Oncogenic Raf-1 regulates epithelial to mesenchymal transition via distinct signal transduction pathways in an immortalized mouse hepatic cell line

Lan, M. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh248 · Cited by 48 · see citing works

Alterations in heart looping induced by overexpression of the tight junction protein Claudin-1 are dependent on its C-terminal cytoplasmic tail

Simard, A., Pietro, E. D., Young, C. R., et al. (2006) · Mechanisms of Development · doi:10.1016/j.mod.2005.12.004 · Cited by 47 · see citing works

Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro

Wattenhofer‐Donzé, M., Reymond, A., Falciola, V., et al. (2005) · Human Mutation · doi:10.1002/humu.20172 · Cited by 46 · see citing works

The Significance of Interferon-γ–Triggered Internalization of Tight-Junction Proteins in Inflammatory Bowel Disease

Chiba, H., Kojima, T., Osanai, M., & Sawada, N. (2006) · Science s STKE · doi:10.1126/stke.3162006pe1 · Cited by 45 · see citing works

Ligand-of-Numb protein X is an endocytic scaffold for junctional adhesion molecule 4

Kansaku, A., Hirabayashi, S., Mori, H., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209468 · Cited by 42 · see citing works

ZOning out Tight Junctions

Shin, K., & Margolis, B. L. (2006) · Cell · doi:10.1016/j.cell.2006.08.005 · Cited by 42 · see citing works

The nuclear receptor hepatocyte nuclear factor 4α acts as a morphogen to induce the formation of microvilli

Chiba, H., Sakai, N., Murata, M., Osanai, M., Ninomiya, T., Kojima, T., & Sawada, N. (2006) · Journal of Cell Biology · doi:10.1083/jcb.200608012 · Cited by 40 · see citing works

Epithelial Tight Junctions

Cereijido, M., González‐Mariscal, L., & Contreras, R. G. (1988) · American Review of Respiratory Disease · doi:10.1164/ajrccm/138.6_pt_2.s17 · Cited by 36 · see citing works

Bves, a member of the Popeye domain‐containing gene family

Osler, M. E., Smith, T. K., & Bader, D. M. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20688 · Cited by 34 · see citing works

Epithelial paracellular proteins in health and disease

Landau, D. (2006) · Current Opinion in Nephrology & Hypertension · doi:10.1097/01.mnh.0000232883.43093.76 · Cited by 31 · see citing works

A CTX Family Cell Adhesion Molecule, JAM4, Is Expressed in Stem Cell and Progenitor Cell Populations of both Male Germ Cell and Hematopoietic Cell Lineages

Nagamatsu, G., Ohmura, M., Mizukami, T., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01502-06 · Cited by 28 · see citing works

Junctional adhesion molecule‐A regulates cell migration and resistance to shear stress

Huang, H., Cruz, F., & Bazzoni, G. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20712 · Cited by 27 · see citing works

Introduction: Evolution of Ideas on the Tight Junction

(2001) · CRC Press eBooks · doi:10.1201/9781420038538-3 · Cited by 23 · see citing works

Occludin and Claudins

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Open Sesame! Coxsackieviruses Conspire to Trespass the Tight Junctional Gate

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Occludin and Claudins: Transmembrane Proteins of the Tight Junction

(2001) · CRC Press eBooks · doi:10.1201/9781420038538-12 · Cited by 4 · see citing works

Regulation of Tight Junction Permeability by Intestinal Bacteria and Dietary Components1,2

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A guide to the organ-on-a-chip

Leung, C. M., de Haan, P., Ronaldson-Bouchard, K., Kim, G.-A., Ko, J., Rho, H. S., Chen, Z., Habibovic, P., Jeon, N. L., Takayama, S., et al. (2022) · Nature Reviews Methods Primers · doi:10.1038/s43586-022-00118-6 · Cited by 1,116 · see citing works

Regulation of Intestinal Barrier Function by Microbial Metabolites

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The blood-brain barrier in Alzheimer’s disease

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Mechanism of intranasal drug delivery directly to the brain

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Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by IFN-γ and IL-4

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Regulation of blood-retinal barrier cell-junctions in diabetic retinopathy

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Human Brain Microvascular Endothelial Cells Derived from the BC1 iPS Cell Line Exhibit a Blood-Brain Barrier Phenotype

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Modulation of gastrointestinal barrier and nutrient transport function in farm animals by natural plant bioactive compounds–a comprehensive review

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Geometry of the Gene Expression Space of Individual Cells

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Expression of tight junction proteins in low and high resistance epithelial cell lines MDCK-C7 and -C11

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Maintaining the intestinal barrier : the role of the tight junction protein occludin in Toxoplasma gondii transmigration of the gastrointestinal tract

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Perspectives on tight junction research

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Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs

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Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein.

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