The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Targeting of human DNA polymerase ι to the replication machinery via interaction with PCNA
Open accessAbstract
Human DNA polymerase ι (hPolι) promotes translesion synthesis by inserting nucleotides opposite highly distorting or noninstructional DNA lesions. Here, we provide evidence for the physical interaction of hPolι with proliferating cell nuclear antigen (PCNA), and show that PCNA, together with replication factor C (RFC) and replication protein A (RPA), stimulates the DNA synthetic activity of hPolι. In the presence of these protein factors, on undamaged DNA, the efficiency ( V max / K m ) of correct nucleotide incorporation by hPolι is increased ≈80–150-fold, and this increase in efficiency results from a reduction in the apparent K m for the nucleotide. PCNA, RFC, and RPA also stimulate nucleotide incorporation opposite the 3′-T of the (6) thymine–thymine (T-T) photoproduct and opposite an abasic site. The interaction of hPolι with PCNA implies that the targeting of this polymerase to the replication machinery stalled at a lesion site is achieved via this association.
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Cites
Biochemical Basis of DNA Replication Fidelity
Goodman, M. F., Creighton, S., Bloom, L. B., Petruska, J., & Kunkel, T. A. (1993) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239309086792 · Cited by 446
polι, a remarkably error-prone human DNA polymerase
Tissier, A., McDonald, J. P., Frank, E. G., & Woodgate, R. (2000) · Genes & Development · doi:10.1101/gad.14.13.1642 · Cited by 315
Kim, J., Patel, D., & Choi, B. (1995) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1995.tb05236.x · Cited by 240
Preferential Incorporation of G Opposite Template T by the Low-Fidelity Human DNA Polymerase ι
Zhang, Y., Yuan, F., Wu, X., & Wang, Z. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.19.7099-7108.2000 · Cited by 200
Cited by
Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes
Goodman, M. F. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.083101.124707 · Cited by 727
Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance
Waters, L. S., Minesinger, B. K., Wiltrout, M. E., D'Souza, S., Woodruff, R. V., & Walker, G. C. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00034-08 · Cited by 591
Translesion DNA synthesis in eukaryotes: A one- or two-polymerase affair
Prakash, S., & Prakash, L. (2002) · Genes & Development · doi:10.1101/gad.1009802 · Cited by 344
Self-citationMcIlwraith, M. J., Vaisman, A., Liu, Y., Fanning, E., Woodgate, R., & West, S. C. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.001 · Cited by 306
How DNA lesions are turned into mutations within cells?
Pagès, V., & Fuchs, R. P. (2002) · Oncogene · doi:10.1038/sj.onc.1206006 · Cited by 237
Metadata
- Authors
- Haracska, L., Johnson, R. E., Unk, I., Phillips, B. B., Hurwitz, J., Prakash, L., & Prakash, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-11-27
- Volume
- 98
- Issue
- 25
- Pages
- 14256-14261
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1982897179
- Cited by
- 193
- References
- 4
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Haracska, L., Johnson, R. E., Unk, I., Phillips, B. B., Hurwitz, J., Prakash, L., & Prakash, S. (2001). Targeting of human DNA polymerase ι to the replication machinery via interaction with PCNA. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.261560798
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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