Translesion DNA synthesis in eukaryotes: A one- or two-polymerase affair
Open accessAbstract
Cellular DNA is continually damaged by a plethora of extrinsic and intrinsic sources, including UV light from the sun and reactive oxygen species resulting from aerobic respiration. Although cells possess a variety of repair processes to remove DNA lesions, lesions that escape repair can block the replicational machinery, and there has been little understanding of the mechanisms by which eukaryotic cells overcome such blocks and promote the continuity of the newly replicated DNA strand. The past three years, however, have witnessed phenomenal progress in this area of research, and here we highlight the important findings and major conclusions that have emerged regarding translesion DNA synthesis (TLS) in eukaryotes.
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Certain polymerases like Pol ζ and Pol η are reported to be particularly promiscuous at mismatch extension, which may reflect their special roles in extending damaged primer-templates following incorporation opposite a lesion by another polymerase.
“Certain polymerases like Pol and Pol are reported to be particularly promiscuous at mismatch extension (10), which may reflect their special roles in extending damaged primer-templates following incorporation opposite a lesion by another polymerase (10).”
From DNA Replication Fidelity (2004) · cites this paper as [10]
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Kannouche, P. (2003) · Biochimie · doi:10.1016/j.biochi.2003.10.009 · Cited by 60 · see citing works
Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics
Korzhnev, D. M., & Hadden, M. K. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b00596 · Cited by 58 · see citing works
Control of DNA Damage Bypass by Ubiquitylation of PCNA
Ripley, B. M., Gildenberg, M. S., & Washington, M. T. (2020) · Genes · doi:10.3390/genes11020138 · Cited by 48 · see citing works
Sail, V., Rizzo, A. A., Chatterjee, N., Dash, R. C., Ozen, Z., Walker, G. C., Korzhnev, D. M., & Hadden, M. K. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.6b01144 · Cited by 52 · see citing works
- Authors
- Prakash, S., & Prakash, L.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2002-08-01
- Volume
- 16
- Issue
- 15
- Pages
- 1872-1883
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2139137226
- Cited by
- 344
- References
- 85
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 6 · 2021: 8 · 2020: 11 · 2019: 8 · 2018: 7 · 2017: 10 · 2016: 14 · 2015: 12 · 2014: 10 · 2013: 11 · 2012: 21
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- translesion synthesis, DNA polymerase, DNA replication, DNA damage, replication fork stalling, DNA repair, UV-induced DNA damage, reactive oxygen species, eukaryotic DNA replication
- MeSH terms
- Y-Family DNA Polymerases, Animals, Bacterial Proteins, DNA, DNA Damage, DNA-Directed DNA Polymerase, Eukaryotic Cells, Humans, Models, Molecular, Neoplastic Syndromes, Hereditary, Nucleic Acid Conformation, Prokaryotic Cells, Protein Conformation, Proteins, Pyrimidine Dimers, Substrate Specificity, Xeroderma Pigmentosum, Archaeal Proteins, Base Pair Mismatch, Saccharomyces cerevisiae Proteins, Escherichia coli Proteins, Mice
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