The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Reversing cerebellar long-term depression
Open accessAbstract
The discovery of a postsynaptically expressed form of cerebellar parallel fiber–Purkinje cell long-term potentiation (LTP) raises the question whether this is the long-sought resetting mechanism for long-term depression (LTD). Extracellular monitoring of PC spikes enables stable prolonged recordings of parallel fiber–Purkinje cell synaptic efficacy. LTD, saturated by repeated induction protocols, can be reversed by a single round of postsynaptic LTP or nitric oxide (NO), enabling LTD to be reinduced. Conversely, after postsynaptic LTP has been saturated, one round of LTD permits fresh postsynaptic LTP. By contrast, after saturation of LTD, induction of presynaptic LTP or application of forskolin leaves LTD still saturated. Likewise, presynaptic LTP cannot be reversed by LTD. Therefore postsynaptic LTP mediated by NO without postsynaptic Ca 2+ elevation, unlike presynaptic LTP mediated by cAMP, is a true counterbalance to LTD mediated by coincidence of NO plus postsynaptic Ca 2+
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Cites
Impaired Cerebellar Long-Term Potentiation in Type I Adenylyl Cyclase Mutant Mice
Storm, D. R., Hansel, C., Hacker, B., Parent, A., & Linden, D. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80500-0 · Cited by 159
Wang, S. S.-H., Khiroug, L., & Augustine, G. J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130414597 · Cited by 104
Cited by
Cerebellar circuitry as a neuronal machine
Ito, M. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.02.006 · Cited by 880
Cerebellum-dependent learning: the role of multiple plasticity mechanisms
Boyden, E. S., Katoh, A., & Raymond, J. L. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144238 · Cited by 448
Jörntell, H., & Hansel, C. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.032 · Cited by 383
Design of a Neurally Plausible Model of Fear Learning
Krasne, F. B., Fanselow, M. S., & Zelikowsky, M. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00041 · Cited by 51
Synergistic excitability plasticity in cerebellar functioning
Ohtsuki, G., Shishikura, M., & Ozaki, A. (2020) · The FEBS Journal · doi:10.1111/febs.15355 · Cited by 27
Metadata
- Authors
- Lev-Ram, V., Mehta, S. B., Kleinfeld, D., & Tsien, R. Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-12-11
- Volume
- 100
- Issue
- 26
- Pages
- 15989-15993
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2101262226
- Cited by
- 166
- References
- 2
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Lev-Ram, V., Mehta, S. B., Kleinfeld, D., & Tsien, R. Y. (2003). Reversing cerebellar long-term depression. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2636935100
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
