Design of a Neurally Plausible Model of Fear Learning

Krasne, Franklin B.; Fanselow, Michael S.; Zelikowsky, Moriel

doi:10.3389/fnbeh.2011.00041

Cited by 51Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Design of a Neurally Plausible Model of Fear Learning

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Krasne, Franklin B., Fanselow, Michael S., Zelikowsky, Moriel·2011·Frontiers in Behavioral Neuroscience

DOI 10.3389/fnbeh.2011.00041PMC PMC3145244

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Abstract

A neurally oriented conceptual and computational model of fear conditioning manifested by freezing behavior (FRAT), which accounts for many aspects of delay and context conditioning, has been constructed. Conditioning and extinction are the result of neuromodulation-controlled LTP at synapses of thalamic, cortical, and hippocampal afferents on principal cells and inhibitory interneurons of lateral and basal amygdala. The phenomena accounted for by the model (and simulated by the computational version) include conditioning, secondary reinforcement, blocking, the immediate shock deficit, extinction, renewal, and a range of empirically valid effects of pre- and post-training ablation or inactivation of hippocampus or amygdala nuclei.

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Animal models suggest the periaqueductal gray is critical for integrating expectations with ascending nociceptive information.
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Authors: Krasne, F. B., Fanselow, M. S., & Zelikowsky, M.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Krasne, Franklin B.
ORCID: Krasne, Franklin B.
Fanselow, Michael S.
Zelikowsky, Moriel
Venue: Frontiers in Behavioral Neuroscience
Publisher: Frontiers Media SA
Published: 2011
Volume: 5
Pages: 41-41
ISSN: 1662-5153 (ISSN-L)
DOI: 10.3389/fnbeh.2011.00041
PMC: PMC3145244
OpenAlex: W2008291372
Cited by: 51
References: 193
Citations by year: 2026: 2 · 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 1 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 3 · 2013: 7 · 2012: 5
FWCI: 2.41
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: fear conditioning, freezing behavior, delay conditioning, contextual conditioning, extinction, renewal, hippocampus, amygdala, long-term potentiation, neuromodulation, thalamocortical synapses, inhibitory interneurons, blocking, secondary reinforcement, computational model

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