Experiments with the Chemostat on Spontaneous Mutations of Bacteria
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Fast, low-cost, accurate detection of time-resolved dynamic nucleic acid conformational variation in response to small molecule binding: 1) enriches our understanding of nucleic acid structure, and regulation of structure by small molecules as ...Nucleic acids can undergo conformational changes upon binding small molecules. These conformational changes can be exploited to develop new therapeutic strategies through control of gene expression or triggering of cellular responses and can also be used ...
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- Authors
- Novick, A., & Szilard, L.
- Affiliations
- University of Chicago (US)
- ORCID
- Novick, Aaron
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1950-12
- Volume
- 36
- Issue
- 12
- Pages
- 708-719
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1063276
- OpenAlex
- W2072002842
- Cited by
- 725
- References
- 0
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 29 · 2023: 16 · 2022: 16 · 2021: 24 · 2020: 14 · 2019: 27 · 2018: 16 · 2017: 20 · 2016: 14 · 2015: 11 · 2014: 22 · 2013: 14 · 2012: 8
- FWCI
- 19.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mathematical and Theoretical Epidemiology and Ecology Models
- Keywords
- chemostat, spontaneous mutation, bacterial evolution, mutation rate, Escherichia coli, continuous culture
- MeSH terms
- Bacteria, Genetics, Mutation
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