INHIBITION OF PROTEIN SYNTHESIS BY CHLORTETRACYCLINE IN THE E. COLI IN VITRO SYSTEM
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Typical tetracyclines inhibit accommodation of aminoacyl-tRNA into the ribosomal A site and prevent addition of new amino acids to the growing polypeptide.
“More precisely, they inhibit accommodation of aminoacyl-tRNA (aa-tRNA) into the ribosomal A site (Fig. 1, reactions a and b) and, therefore, prevent the addition of new amino acids to the growing polypeptide (22, 25, 29, 48).”
From Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance (2003) · cites this paper as [25]
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- Authors
- Hierowski, M.
- Affiliations
- THE ROCKEFELLER INSTITUTE
- Corresponding author
- Hierowski, Marian
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1965-03
- Volume
- 53
- Issue
- 3
- Pages
- 594-599
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC336982
- OpenAlex
- W1990692448
- Cited by
- 83
- References
- 15
- Citations by year
- 2020: 2 · 2018: 2 · 2014: 2
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Keywords
- chlortetracycline, protein synthesis inhibition, Escherichia coli, tetracycline antibiotics, bacterial translation, cell-free protein synthesis
- MeSH terms
- Anti-Bacterial Agents, Antimetabolites, Carbon Isotopes, Chlortetracycline, Escherichia coli, Magnesium, Phenylalanine, Proteins, Research, RNA, RNA, Viral, Tetracycline, Protein Biosynthesis, In Vitro Techniques
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