Cited by 83RNA and protein synthesis mechanismsBacterial Genetics and BiotechnologyMicrobial Natural Products and Biosynthesis

INHIBITION OF PROTEIN SYNTHESIS BY CHLORTETRACYCLINE IN THE E. COLI IN VITRO SYSTEM

Open access
Hierowski, Marian·1965·Proceedings of the National Academy of Sciences

Integrity signals

Registry

Crossref · 10.1073/pnas.53.3.594

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Typical tetracyclines inhibit accommodation of aminoacyl-tRNA into the ribosomal A site and prevent addition of new amino acids to the growing polypeptide.

    “More precisely, they inhibit accommodation of aminoacyl-tRNA (aa-tRNA) into the ribosomal A site (Fig. 1, reactions a and b) and, therefore, prevent the addition of new amino acids to the growing polypeptide (22, 25, 29, 48).”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Hierowski, M.
Affiliations
THE ROCKEFELLER INSTITUTE
Corresponding author
Hierowski, Marian
Venue
Proceedings of the National Academy of Sciences
Published
1965-03
Volume
53
Issue
3
Pages
594-599
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1990692448
Cited by
83
References
15
Citations by year
2020: 2 · 2018: 2 · 2014: 2
FWCI
7.12
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Science Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
Keywords
chlortetracycline, protein synthesis inhibition, Escherichia coli, tetracycline antibiotics, bacterial translation, cell-free protein synthesis
MeSH terms
Anti-Bacterial Agents, Antimetabolites, Carbon Isotopes, Chlortetracycline, Escherichia coli, Magnesium, Phenylalanine, Proteins, Research, RNA, RNA, Viral, Tetracycline, Protein Biosynthesis, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review