The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
BACITRACIN: AN INHIBITOR OF THE DEPHOSPHORYLATION OF LIPID PYROPHOSPHATE, AN INTERMEDIATE IN THE BIOSYNTHESIS OF THE PEPTIDOGLYCAN OF BACTERIAL CELL WALLS
Open accessAbstract
Bacitraciin is a polypeptide antibiotic produced by certain strainis of Bacillus licheniformis. It inhibits bacterial cell wall synthesis and induces the accumulation in Staphylococcus aureus of UDP-acetylmuramyl-pentapeptide,I a precursor of the cell wall. Recent studies of the detailed mechanism of biosynthesis of the peptidoglycaii of bacterial cell walls have revealed a process that occurs in three stages, viz.: (1) biosynthesis of the uridinie nucleotide precursors, (2) utilization of these precursors to form linear peptidoglycari strands, and (3) cross-linking of the liinearstrands.2 Each of these stages is specifically inhibited by different anti.biotics. Ristocetin, vancomycin, and bacitracin are all inhibitors of the second stage.3 This stage is a complex reaction sequence which occurs in the cell membralle as a consequence of which the sugar fragments of the uridine nucleotide precursors become attached to a phospholipid carrier in the membrane and are then modified. Studies of the individual reactions in this cycle (Fig. 1) have revealed that the re
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Cites
Tipper, D. J., & Strominger, J. L. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.54.4.1133 · Cited by 1,008
Self-citationAnderson, J. S., Matsuhashi, M., Haskin, M. A., & Strominger, J. L. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.53.4.881 · Cited by 317
Self-citationBiosynthesis of the peptidoglycan of bacterial cell walls
Anderson, J. S., Meadow, P. M., Haskin, M. A., & Strominger, J. L. (1966) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(66)90056-7 · Cited by 264
Self-citationLysostaphin: Enzymatic mode of action
Browder, H. P., Zygmunt, W. A., Young, J. R., & Tavormina, P. A. (1965) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(65)90473-0 · Cited by 230
Isolation and utilization of phospholipid intermediates in cell wall glycopeptide synthesis
Anderson, J. S., & Strominger, J. L. (1965) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(65)90414-6 · Cited by 32
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Cited by
Overview of the Antimicrobial Compounds Produced by Members of the Bacillus subtilis Group
Caulier, S., Nannan, C., Gillis, A., Licciardi, F., Bragard, C., & Mahillon, J. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00302 · Cited by 817
Use of bacteriolytic enzymes in determination of wall structure and their role in cell metabolism
Ghuysen, J. M. (1968) · Bacteriological Reviews · doi:10.1128/mmbr.32.4_pt_2.425-464.1968 · Cited by 569
Mechanism of Action of Bacitracin: Complexation with Metal Ion and C 55 -Isoprenyl Pyrophosphate
Stone, K. J., & Strominger, J. L. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.12.3223 · Cited by 377
Self-citationStructure and Metabolism of Connective Tissue Proteoglycans
Rodén, L. (1980) · The Biochemistry of Glycoproteins and Proteoglycans · doi:10.1007/978-1-4684-1006-8_7 · Cited by 377
Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus
Ton-That, H., Mazmanian, S. K., Faull, K. F., & Schneewind, O. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.13.9876 · Cited by 359
Metadata
- Authors
- Siewert, G., & Strominger, J. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1967-03
- Volume
- 57
- Issue
- 3
- Pages
- 767-773
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2079698915
- Cited by
- 296
- References
- 5
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: BACITRACIN: AN INHIBITOR OF THE DEPHOSPHORYLATION OF LIPID PYROPHOSPHATE, AN INTERMEDIATE IN THE BIOSYNTHESIS OF THE PEPTIDOGLYCAN OF BACTERIAL CELL WALLS. https://app.cochat.ai/papers/10.1073/pnas.57.3.767
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- Siewert, G., & Strominger, J. L. (1967). BACITRACIN: AN INHIBITOR OF THE DEPHOSPHORYLATION OF LIPID PYROPHOSPHATE, AN INTERMEDIATE IN THE BIOSYNTHESIS OF THE PEPTIDOGLYCAN OF BACTERIAL CELL WALLS. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.57.3.767
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
