The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Mechanism of Action of Bacitracin: Complexation with Metal Ion and C 55 -Isoprenyl Pyrophosphate
Open accessAbstract
The inhibition by bacitracin of the enzymatic dephosphorylation of C 55 -isoprenyl pyrophosphate is abolished by the addition of chelating agents. If, however, the chelating agent is added after a preincubation of bacitracin with a divalent cation and the lipid substrate, then its addition has little effect, indicating that bacitracin, metal ion, and C 55 -isoprenyl pyrophosphate form a complex. Various divalent cations can participate in complex formation, but monovalent cations are ineffective. A direct demonstration of the formation of a complex between the C 55 -isoprenyl pyrophosphate and bacitracin in the presence of metal ions was obtained. Molecular models that show one possible conformation for a complex between bacitracin and the C 55 -isoprenyl pyrophosphate, in which the metal ion acts as a bridge between the two compounds, are presented.
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Cites
Measurement of protein-binding phenomena by gel filtration
Hummel, J. P., & Dreyer, W. J. (1962) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(62)90124-5 · Cited by 1,279
Antimicrobial Agents and Chemotherapy
(2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac · Cited by 485
Siewert, G., & Strominger, J. L. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.57.3.767 · Cited by 296
Self-citationBiosynthesis of the peptidoglycan of bacterial cell walls
Anderson, J. S., Meadow, P. M., Haskin, M. A., & Strominger, J. L. (1966) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(66)90056-7 · Cited by 264
Self-citationBiosynthesis of the Peptidoglycan of Bacterial Cell Walls
Anderson, J. S., Matsuhashi, M., Haskin, M. A., & Strominger, J. L. (1967) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)95949-1 · Cited by 189
Self-citationBiosynthesis of the Peptidoglycan of Bacterial Cell Walls
Higashi, Y., Siewert, G., & Strominger, J. L. (1970) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62980-1 · Cited by 96
Self-citationBacitracin A. Isolation by counter double-current distribution and characterization
Craig, L. C., Phillips, W. F., & Burachik, M. (1969) · Biochemistry · doi:10.1021/bi00834a015 · Cited by 58
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Elbein, A. D. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.002433 · Cited by 1,122
Stress Physiology of Lactic Acid Bacteria.
Papadimitriou, K., Alegría, Á., Bron, P. A., de Angelis, M., Gobbetti, M., Kleerebezem, M., Lemos, J. A., Linares, D. M., Ross, P., Stanton, C., et al. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00076-15 · Cited by 914
Control of Cell Morphogenesis in Bacteria
Daniel, R. A., & Errington, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00421-5 · Cited by 740
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Sieber, S. A., & Marahiel, M. A. (2005) · Chemical Reviews · doi:10.1021/cr0301191 · Cited by 592
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Metadata
- Authors
- Stone, K. J., & Strominger, J. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1971-12
- Volume
- 68
- Issue
- 12
- Pages
- 3223-3227
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2131709544
- Cited by
- 377
- References
- 7
- FWCI
- 6.64
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mechanism of Action of Bacitracin: Complexation with Metal Ion and C 55 -Isoprenyl Pyrophosphate. https://app.cochat.ai/papers/10.1073/pnas.68.12.3223
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- Stone, K. J., & Strominger, J. L. (1971). Mechanism of Action of Bacitracin: Complexation with Metal Ion and C 55 -Isoprenyl Pyrophosphate. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.68.12.3223
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
