Specificity of oligonucleotide synthesis directed by polyuridylic acid.
Open accessAbstract
Mutations are important because they provide raw material for evolution. Some types of mutations occur more often than others, and the strength of such mutational bias varies across species. It is not clear how this variation arises. We ...Biased mutation spectra are pervasive, with wide variation in the magnitude of mutational biases that influence genome evolution and adaptation. How do such diverse biases evolve? Our experiments show that changing the mutation spectrum allows populations ...
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No extension of primer 2 by GMP was detectable with EDC alone, even in high-salt buffer containing 0.8 m EDC.
“Initially, no extension of primer 2 by GMP was detectable, even in high-salt buffer containing 0.8 m EDC, and our experimental work aimed at high-yielding reactions was unsuccessful, in agreement with the low yields reported in the early literature.”
From Copying of RNA Sequences without Pre‐Activation (2015) · cites this paper as [31]
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Amino acids catalyse RNA formation under ambient alkaline conditions
Rout, S. K., Wunnava, S., Krepl, M., Cassone, G., Šponer, J. E., Mast, C. B., Powner, M. W., & Braun, D. (2025) · Nature Communications · doi:10.1038/s41467-025-60359-3 · Cited by 15 · see citing works
- Authors
- Sulston, J., Lohrmann, R., Orgel, L. E., & Miles, H. T.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1968-06
- Volume
- 60
- Issue
- 2
- Pages
- 409-415
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC225062
- OpenAlex
- W1986401469
- Cited by
- 57
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 1 · 2021: 1 · 2017: 1 · 2015: 2 · 2012: 2
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- oligonucleotide synthesis, polyuridylic acid, nucleotide specificity, RNA template, nucleic acid synthesis
- MeSH terms
- Adenine Nucleotides, Carbon Isotopes, Cytosine, Cytosine Nucleotides, Guanine, Magnesium, Nucleosides, Polynucleotides, Templates, Genetic, Uracil, Uracil Nucleotides
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