Template-Directed Synthesis with Adenosine-5′-phosphorimidazolide
Abstract
Adenosine-5′-monophosphorimidazolide reacts efficiently with adenosine derivatives on a polyuridylic acid template, with the formation of internucleotide bonds.
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Association of the activated nucleotide poises the complex for reaction, and bond formation is essentially irreversible.
“Association of the activated nucleotide poises the complex for reaction, and bond formation is essentially irreversible (Figure 1E).”
From The paradox of dual roles in the RNA world: resolving the conflict between stable folding and templating ability (2013) · cites this paper as Weimann et al. 1968
Cites
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Generation of RNA Molecules by a Base‐Catalysed Click‐Like Reaction
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Sequencing of <scp>d</scp>/<scp>l</scp>-DNA and XNA by Templated-Synthesis
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- Authors
- Weimann, B. J., Lohrmann, R., Orgel, L. E., Schneider-Bernloehr, H., & Sulston, J. E.
- Affiliations
- Salk Institute for Biological Studies (US)
- ORCID
- Weimann, B. J.
- Venue
- Science
- Published
- 1968-07-26
- Volume
- 161
- Issue
- 3839
- Pages
- 387-387
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2035016120
- Cited by
- 166
- References
- 10
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 7 · 2023: 15 · 2022: 7 · 2021: 6 · 2020: 12 · 2019: 7 · 2018: 9 · 2017: 6 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 5
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Physical Sciences › Chemistry › Organic Chemistry › Chemical Reaction Mechanisms
- Keywords
- template synthesis, adenosine derivatives, nucleotide analogues, oligonucleotide synthesis
- MeSH terms
- Adenine Nucleotides, Carbon Isotopes, Hydrogen-Ion Concentration, Imidazoles, Polynucleotides, Templates, Genetic, Uracil Nucleotides
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