The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
XERODERMA PIGMENTOSUM: A HUMAN DISEASE IN WHICH AN INITIAL STAGE OF DNA REPAIR IS DEFECTIVE
Open accessAbstract
Homozygous xeroderma pigmentosum fibroblasts cannot repair damage to DNA bases, but can repair damage that involves chain breaks. In xeroderma pigmentosum, therefore, there is a defect in an early step in repair at which base damage is recognized and the polynucleotide chain broken enzymatically (by an endonuclease). Heterozygous fibroblasts repair base damage to normal extents. Carcinogenesis in xeroderma pigmentosum, and perhaps in some normal individuals, may be the result of somatic mutations caused by unrepaired damage.
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Citations
Cites
Defective repair replication of DNA in xeroderma pigmentosum
CLEAVER, J. E. (1968) · Nature · doi:10.1038/218652a0 · Cited by 1,729
Self-citationOn the nature of the aging process
Szilard, L. (1959) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.45.1.30 · Cited by 651
Cited by
DNA repair, genome stability and cancer: a historical perspective
Jeggo, P. A., Pearl, L. H., & Carr, A. M. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2015.4 · Cited by 774
Formation of UV-induced DNA damage contributing to skin cancer development
Cadet, J., & Douki, T. (2018) · Photochemical & Photobiological Sciences · doi:10.1039/c7pp00395a · Cited by 435
DNA repair and aging in basal cell carcinoma: a molecular epidemiology study.
Wei, Q., Matanoski, G. M., Farmer, E. R., Hedayati, M. A., & Grossman, L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.4.1614 · Cited by 414
Immunodepression and Malignancy
(1976) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60179-7 · Cited by 308
Mechanisms of UV-induced mutations and skin cancer
Pfeifer, G. P. (2020) · Genome Instability & Disease · doi:10.1007/s42764-020-00009-8 · Cited by 237
Metadata
- Authors
- Cleaver, J. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1969-06
- Volume
- 63
- Issue
- 2
- Pages
- 428-435
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2052152963
- Cited by
- 415
- References
- 2
- FWCI
- 14.19
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: XERODERMA PIGMENTOSUM: A HUMAN DISEASE IN WHICH AN INITIAL STAGE OF DNA REPAIR IS DEFECTIVE. https://app.cochat.ai/papers/10.1073/pnas.63.2.428
- The paper
- Cleaver, J. E. (1969). XERODERMA PIGMENTOSUM: A HUMAN DISEASE IN WHICH AN INITIAL STAGE OF DNA REPAIR IS DEFECTIVE. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.63.2.428
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
