Formation of UV-induced DNA damage contributing to skin cancer development
Open accessAbstract
UV-induced DNA damage plays a key role in the initiation phase of skin cancer. When left unrepaired or when damaged cells are not eliminated by apoptosis, DNA lesions express their mutagneic properties, leading to the activation of proto-oncogene or the inactivation of tumor suppression genes. The chemical nature and the amount of DNA damage strongly depend on the wavelength of the incident photons. The most energetic part of the solar spectrum at the Earth's surface (UVB, 280-320 nm) leads to the formation of cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6-4) pyrimidone photoproducts (64PPs). Less energetic but 20-times more intense UVA (320-400 nm) also induces the formation of CPDs together with a wide variety of oxidatively generated lesions such as single strand breaks and oxidized bases. Among those, 8-oxo-7,8-dihydroguanine (8-oxoGua) is the most frequent since it can be produced by several mechanisms. Data available on the respective yield of DNA photoproducts in cells and skin show that exposure to sunlight mostly induces pyrimidine dimers, which explains the mutational signature found in skin tumors, with lower amounts of 8-oxoGua and strand breaks. The present review aims at describing the basic photochemistry of DNA and discussing the quantitative formation of the different UV-induced DNA lesions reported in the literature. Additional information on mutagenesis, repair and photoprotection is briefly provided.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
A role for sunlight in skin-cancer – UV-induced p53 mutations in squamous-cell carcinoma
Brash, D. E., Rudolph, J. A., Simon, J. A., Lin, A., McKenna, G. J., Baden, H. P., Halperin, A. J., & Pontén, J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10124 · Cited by 1,959 · see citing works
Definition of type I and type II photosensitized oxidation
Foote, C. S. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb02071.x · Cited by 1,248 · see citing works
Green, A., Williams, G., Nèale, R., Hart, V., Leslie, D., Parsons, P., Marks, G. C., Gaffney, P., Battistutta, D., Frost, C., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(98)12168-2 · Cited by 976 · see citing works
Ultraviolet radiation-mediated damage to cellular DNA
Cadet, J., Sage, E., & Douki, T. (2005) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.09.012 · Cited by 932 · see citing works
Self-citationType I and Type II Photosensitized Oxidation Reactions: Guidelines and Mechanistic Pathways
Baptista, M. S., Cadet, J., Mascio, P. D., Ghogare, A. A., Greer, A., Hamblin, M. R., Lorente, C., Núñez, S. C., Ribeiro, M. S., Thomas, A. H., et al. (2017) · Photochemistry and Photobiology · doi:10.1111/php.12716 · Cited by 924 · see citing works
Self-citationDNA Base Damage by Reactive Oxygen Species, Oxidizing Agents, and UV Radiation
Cadet, J., & Wagner, J. R. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012559 · Cited by 903 · see citing works
Self-citationA review of human carcinogens--part D: radiation
El Ghissassi, F., Baan, R., Straif, K., Grosse, Y., Secretan, B., Bouvard, V., Benbrahim-Tallaa, L., Guha, N., Freeman, C., Galichet, L., et al. (2009) · The Lancet Oncology · doi:10.1016/s1470-2045(09)70213-x · Cited by 900 · see citing works
Peroxynitrite, a Stealthy Biological Oxidant
Radí, R. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r113.472936 · Cited by 891 · see citing works
Hollow Capsule Processing through Colloidal Templating and Self-Assembly
Caruso, F. (2000) · Chemistry - A European Journal · doi:10.1002/(sici)1521-3765(20000204)6:3 · Cited by 883 · see citing works
DNA Excited-State Dynamics: From Single Bases to the Double Helix
Middleton, C. T., de La Harpe, K., Su, C., Law, Y. K., Crespo-Hernández, C. E., & Kohler, B. (2009) · Annual Review of Physical Chemistry · doi:10.1146/annurev.physchem.59.032607.093719 · Cited by 827 · see citing works
Direct observation of hole transfer through DNA by hopping between adenine bases and by tunnelling
Giese, B., Amaudrut, J., Köhler, A.-K., Spormann, M., & Wessely, S. (2001) · Nature · doi:10.1038/35085542 · Cited by 823 · see citing works
Free-Radical-Induced DNA Damage and Its Repair
von Sonntag, C. (2006) · Springer eBooks · doi:10.1007/3-540-30592-0 · Cited by 811 · see citing works
Reduced melanoma after regular sunscreen use: randomized trial follow-up
Green, A. C., Williams, G. M., Logan, V., & Strutton, G. M. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.7078 · Cited by 799 · see citing works
Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.
Ziegler, A., Leffell, D. J., Kunala, S., Sharma, H. W., Gailani, M. R., Simon, J. A., Halperin, A. J., Baden, H. P., Shapiro, P. E., & Bale, A. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4216 · Cited by 739 · see citing works
Mouret, S., Baudouin, C., Charveron, M., Favier, A., Cadet, J., & Douki, T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604213103 · Cited by 684 · see citing works
Self-citationHydroxyl Free Radical Adduct of Deoxyguanosine: Sensitive Detection and Mechanisms of Formation
Floyd, R. A., Watson, J. J., Wong, P. K., Altmiller, D. H., & Rickard, R. C. (1986) · Free Radical Research Communications · doi:10.3109/10715768609083148 · Cited by 663 · see citing works
Microarrays and toxicology: The advent of toxicogenomics
Nuwaysir, E. F., Bittner, M. L., Trent, J. M., Barrett, J. C., & Afshari, C. A. (1999) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199903)24:3 · Cited by 656 · see citing works
Wavelength dependence of oxidative DNA damage induced by UV and visible light
Kielbassa, C. (1997) · Carcinogenesis · doi:10.1093/carcin/18.4.811 · Cited by 616 · see citing works
Skin cancer and solar UV radiation
de Gruijl, F. R. (1999) · European Journal of Cancer · doi:10.1016/s0959-8049(99)00283-x · Cited by 602 · see citing works
Cadet, J., Douki, T., & Ravanat, J.-L. (2008) · Accounts of Chemical Research · doi:10.1021/ar700245e · Cited by 555 · see citing works
Self-citationChemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure
Premi, S., Wallisch, S., Mano, C. M., Weiner, A. B., Bacchiocchi, A., Wakamatsu, K., Bechara, E. J. H., Halaban, R., Douki, T., & Brash, D. E. (2015) · Science · doi:10.1126/science.1256022 · Cited by 550 · see citing works
Self-citationThymine Dimerization in DNA Is an Ultrafast Photoreaction
Schreier, W. J., Schrader, T. E., Koller, F. O., Gilch, P., Crespo-Hernández, C. E., Swaminathan, V. N., Carell, T., Zinth, W., & Kohler, B. (2007) · Science · doi:10.1126/science.1135428 · Cited by 550 · see citing works
Oxidatively generated base damage to cellular DNA
Cadet, J., Douki, T., & Ravanat, J. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.03.025 · Cited by 543 · see citing works
Self-citationAgar, N., Halliday, G. M., Barnetson, R. S., Ananthaswamy, H. N., Wheeler, M., & Jones, A. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401141101 · Cited by 530 · see citing works
The Mechanisms of UV Mutagenesis
Ikehata, H., & Ono, T. (2011) · Journal of Radiation Research · doi:10.1269/jrr.10175 · Cited by 515 · see citing works
Kalyanaraman, B. (2013) · Redox Biology · doi:10.1016/j.redox.2013.01.014 · Cited by 502 · see citing works
Biological effects and medical applications of infrared radiation
Tsai, S.-R., & Hamblin, M. R. (2017) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2017.04.014 · Cited by 497 · see citing works
Isolation and identification of the irradiation product of thymine
Beukers, R., & Berends, W. (1960) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(60)90063-9 · Cited by 476 · see citing works
Douki, T., Reynaud-Angelin, A., Cadet, J., & Sage, E. (2003) · Biochemistry · doi:10.1021/bi034593c · Cited by 452 · see citing works
Self-citationOxidative damage to DNA: Formation, measurement, and biological significance
Cadet, J., Berger, M., Douki, T., & Ravanat, J. (1997) · Springer eBooks · doi:10.1007/3-540-61992-5_5 · Cited by 431 · see citing works
Self-citationSymposium‐in‐Print: Singlet Oxygen Invited Review
Redmond, R. W., & Kochevar, I. E. (2006) · Photochemistry and Photobiology · doi:10.1562/2006-04-14-ir-874 · Cited by 421 · see citing works
Melanocytes as Instigators and Victims of Oxidative Stress
Denat, L., Kadekaro, A. L., Marrot, L., Leachman, S., & Abdel-Malek, Z. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.65 · Cited by 414 · see citing works
XERODERMA PIGMENTOSUM: A HUMAN DISEASE IN WHICH AN INITIAL STAGE OF DNA REPAIR IS DEFECTIVE
Cleaver, J. E. (1969) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.63.2.428 · Cited by 409 · see citing works
Sunlight and skin cancer: another link revealed
Kraemer, K. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.11 · Cited by 403 · see citing works
The role of antioxidants in photoprotection: A critical review
Chen, L., Hu, J. Y., & Wang, S. Q. (2012) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2012.02.009 · Cited by 402 · see citing works
<scp>UV</scp> Signature Mutations
Brash, D. E. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12377 · Cited by 401 · see citing works
UV-induced DNA damage and melanin content in human skin differing in racial/ethnic origin
Tadokoro, T., Kobayashi, N., Zmudzka, B. Z., Ito, S., Wakamatsu, K., Yamaguchi, Y., Korossy, K. S., Miller, S. A., Beer, J. Z., & Hearing, V. J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0865fje · Cited by 378 · see citing works
Mechanisms and prevention of <scp>UV</scp>‐induced melanoma
Sample, A., & He, Y. (2018) · Photodermatology, Photoimmunology & Photomedicine · doi:10.1111/phpp.12329 · Cited by 372 · see citing works
Cellular and molecular events leading to the development of skin cancer
Melnikova, V. O., & Ananthaswamy, H. N. (2005) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2004.11.015 · Cited by 370 · see citing works
Cadet, J., Douki, T., & Ravanat, J. (2015) · Photochemistry and Photobiology · doi:10.1111/php.12368 · Cited by 355 · see citing works
Self-citationInduction of oxidative DNA base damage in human skin cells by UV and near visible radiation
Kvam, E. (1997) · Carcinogenesis · doi:10.1093/carcin/18.12.2379 · Cited by 344 · see citing works
Douki, T., & Cadet, J. (2001) · Biochemistry · doi:10.1021/bi0022543 · Cited by 337 · see citing works
Self-citationCadet, J., Berger, M., Buchko, G. W., Joshi, P. C., Raoul, S., & Ravanat, J. (1994) · Journal of the American Chemical Society · doi:10.1021/ja00095a052 · Cited by 333 · see citing works
Self-citationMelanoma induction by ultraviolet A but not ultraviolet B radiation requires melanin pigment
Noonan, F. P., Zaidi, M. R., Wolnicka-Glubisz, A., Anver, M. R., Bahn, J., Wielgus, A., Cadet, J., Douki, T., Mouret, S., Tucker, M. A., et al. (2012) · Nature Communications · doi:10.1038/ncomms1893 · Cited by 331 · see citing works
Self-citationSinglet Oxygen Induces Oxidation of Cellular DNA
Ravanat, J., Mascio, P. D., Martinez, G. R., de Medeiros, M. H. G., & Cadet, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006681200 · Cited by 327 · see citing works
Self-citationYou, Y.-H., Lee, D.-H., Yoon, J.-H., Nakajima, S., Yasui, A., & Pfeifer, G. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m107696200 · Cited by 314 · see citing works
Freeman, S. E., Hacham, H., Gange, R. W., Maytum, D. J., Sutherland, J. C., & Sutherland, B. M. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5605 · Cited by 311 · see citing works
Devasagayam, T. P. A., Steenken, S., Obendorf, M. S. W., Schulz, W. A., & Sies, H. (1991) · Biochemistry · doi:10.1021/bi00239a029 · Cited by 304 · see citing works
Kasai, H., Yamaizumi, Z., Berger, M., & Cadet, J. (1992) · Journal of the American Chemical Society · doi:10.1021/ja00050a078 · Cited by 300 · see citing works
Self-citationPhotoinduced Damage to Cellular DNA: Direct and Photosensitized Reactions<sup>†</sup>
Cadet, J., Mouret, S., Ravanat, J., & Douki, T. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01200.x · Cited by 300 · see citing works
Self-citationRelationship of Cutaneous Malignant Melanoma to Individual Sunlight-Exposure Habits 2 3
Holman, C., Armstrong, B. K., & Heenan, P. J. (1986) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/76.3.403 · Cited by 297 · see citing works
Unraveling the Molecular Pathway from Sunlight to Skin Cancer
Taylor, J. (1994) · Accounts of Chemical Research · doi:10.1021/ar00039a003 · Cited by 283 · see citing works
Radiation-induced clustered DNA lesions: Repair and mutagenesis
Sage, É., & Shikazono, N. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.12.008 · Cited by 282 · see citing works
Effect of Guanine Stacking on the Oxidation of 8-Oxoguanine in B-DNA
Prat, F., Houk, K. N., & Foote, C. S. (1998) · Journal of the American Chemical Society · doi:10.1021/ja972331q · Cited by 281 · see citing works
Mitchell, D. L., Haipek, C. A., & Clarkson, J. M. (1985) · Mutation Research Letters · doi:10.1016/s0165-7992(85)80018-x · Cited by 277 · see citing works
Lee, P. C. C., & Rodgers, M. A. J. (1987) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1987.tb08407.x · Cited by 274 · see citing works
Pouget, J.-P., Douki, T., Richard, M.-J., & Cadet, J. (2000) · Chemical Research in Toxicology · doi:10.1021/tx000020e · Cited by 274 · see citing works
Self-citationFrelon, S., Douki, T., Ravanat, J.-L., Pouget, J.-P., Tornabene, C., & Cadet, J. (2000) · Chemical Research in Toxicology · doi:10.1021/tx000085h · Cited by 271 · see citing works
Self-citationBenzophenone Photosensitized DNA Damage
Cuquerella, M. C., Lhiaubet‐Vallet, V., Cadet, J., & Miranda, M. A. (2012) · Accounts of Chemical Research · doi:10.1021/ar300054e · Cited by 262 · see citing works
Self-citationVariations in skin colour and the biological consequences of ultraviolet radiation exposure
Bino, S. D., & Bernerd, F. (2013) · British Journal of Dermatology · doi:10.1111/bjd.12529 · Cited by 261 · see citing works
Hu, J., Adar, S., Selby, C. P., Lieb, J. D., & Sancar, A. (2015) · Genes & Development · doi:10.1101/gad.261271.115 · Cited by 249 · see citing works
Distribution and Repair of Bipyrimidine Photoproducts in Solar UV-irradiated Mammalian Cells
Perdiz, D., Gróf, P., Mezzina, M., Nikaido, O., Moustacchi, E., & Sage, E. (2000) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61437-7 · Cited by 248 · see citing works
Douki, T., Court, M., Sauvaigo, S., Odin, F., & Cadet, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.11678 · Cited by 239 · see citing works
Self-citationKuluncsics, Z., Perdiz, D., Brulay, E., Muel, B., & Sage, E. (1999) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(99)00034-2 · Cited by 239 · see citing works
Sunlight induces pyrimidine dimers preferentially at 5-methylcytosine bases.
Tommasi, S., Denissenko, M. F., & Pfeifer, G. P. (1997) · PubMed · Cited by 237 · see citing works
Sunscreen Use, Wearing Clothes, and Number of Nevi in 6- to 7-Year-Old European Children
Autier, P., Mezzetti, M., Doré, J., Monjaud, I., Cattaruzza, M. S., Luther, H., Renard, F., Andry, M., A-R, G., Gentiloni-Silverj, F., et al. (1998) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/90.24.1873 · Cited by 233 · see citing works
Oxidatively generated complex DNA damage: Tandem and clustered lesions
Cadet, J., Ravanat, J.-L., TavernaPorro, M., Menoni, H., & Angelov, D. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.04.005 · Cited by 233 · see citing works
Self-citationRochette, P. J. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg402 · Cited by 231 · see citing works
Powerful Skin Cancer Protection by a CPD-Photolyase Transgene
Jans, J., Schul, W., Sert, Y.-G., Rijksen, Y., Rebel, H., Eker, A. P. M., Nakajima, S., van Steeg, H., de Gruijl, F. R., Yasui, A., et al. (2005) · Current Biology · doi:10.1016/j.cub.2005.01.001 · Cited by 227 · see citing works
Sunscreen use and increased duration of intentional sun exposure: Still a burning issue
Autier, P., Boniol, M., & Doré, J. (2007) · International Journal of Cancer · doi:10.1002/ijc.22745 · Cited by 226 · see citing works
Jansen, R., Osterwalder, U., Wang, S. Q., Burnett, M., & Lim, H. W. (2013) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.08.022 · Cited by 224 · see citing works
Misiaszek, R., Crean, C. W., Joffe, A., Geacintov, N. E., & Shafirovich, V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313904200 · Cited by 221 · see citing works
Long-Range Charge Transfer in DNA II
Schuster, G. B., Angelov, D., & Beratan, D. N. (2004) · Topics in current chemistry · doi:10.1007/b14032 · Cited by 221 · see citing works
The Chemical Toxicology of 2-Deoxyribose Oxidation in DNA
Dedon, P. C. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700283c · Cited by 213 · see citing works
Xeroderma pigmentosum and the role of UV-induced DNA damage in skin cancer
STEEG, H. V., & Kraemer, K. H. (1999) · Molecular Medicine Today · doi:10.1016/s1357-4310(98)01394-x · Cited by 211 · see citing works
Gale, J. M., Nissen, K. A., & Smerdon, M. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.19.6644 · Cited by 210 · see citing works
Leclerc, J.-M., Borden, A., & Lawrence, C. W. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9685 · Cited by 206 · see citing works
Mitchell, D. L., Jen, J., & Cleaver, J. E. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.2.225 · Cited by 205 · see citing works
Short- and Long-Wave UV Light (UVB and UVA) Induce Similar Mutations in Human Skin Cells
Kappes, U. P., Luo, D., Potter, M., Schulmeister, K., & Rünger, T. M. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700093 · Cited by 200 · see citing works
Valencia, A., & Kochevar, I. E. (2008) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700960 · Cited by 194 · see citing works
Genome-wide kinetics of DNA excision repair in relation to chromatin state and mutagenesis
Adar, S., Hu, J., Lieb, J. D., & Sancar, A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603388113 · Cited by 193 · see citing works
Lange, A. W., & Herbert, J. M. (2009) · Journal of the American Chemical Society · doi:10.1021/ja808998q · Cited by 187 · see citing works
Shafirovich, V., Dourandin, A., Huang, W., & Geacintov, N. E. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101131200 · Cited by 186 · see citing works
(Pheo)Melanin photosensitizes UVA–induced DNA damage in cultured human melanocytes
Wenczl, E., Smit, N. P. M., Pavel, S., Schothorst, A. A., Van der Schans, G. P., Timmerman, A. J., Roza, L., & Kolb, R. M. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00357.x · Cited by 186 · see citing works
Dynamic maps of UV damage formation and repair for the human genome
Hu, J., Adebalı, O., Adar, S., & Sancar, A. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1706522114 · Cited by 181 · see citing works
Photosensitized reactions of nucleic acids
Cadet, J., Berger, M., Decarroz, C., Wagner, J. R., van Lier, J. E., Ginot, Y. M., & Vigny, P. (1986) · Biochimie · doi:10.1016/s0300-9084(86)80097-9 · Cited by 177 · see citing works
Self-citationPourzand, C., Watkin, R. D., Brown, J. E., & Tyrrell, R. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.6751 · Cited by 176 · see citing works
DNA, light, and Dewar pyrimidinones: the structure and biological significance to TpT3
Taylor, J. S., & Cohrs, M. P. (1987) · Journal of the American Chemical Society · doi:10.1021/ja00243a052 · Cited by 174 · see citing works
The genomic landscape of cutaneous melanoma
Zhang, T., Dutton‐Regester, K., Brown, K. M., & Hayward, N. K. (2016) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12459 · Cited by 173 · see citing works
Relationship between skin response to ultraviolet exposure and skin color type
Bino, S. D., Sok, J., Bessac, E., & Bernerd, F. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00338.x · Cited by 169 · see citing works
Cadet, J., & Wagner, J. R. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.05.001 · Cited by 169 · see citing works
Self-citationYe, Y., Muller, J. G., Luo, W., Mayne, C. L., Shallop, A. J., Jones, R. A., & Burrows, C. J. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0378660 · Cited by 167 · see citing works
Wagner, J. R., & Cadet, J. (2010) · Accounts of Chemical Research · doi:10.1021/ar9002637 · Cited by 167 · see citing works
Self-citationUnravelling UVA-induced mutagenesis
Sage, E., Girard, P.-M., & Francesconi, S. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05219e · Cited by 167 · see citing works
Crespo‐Hernández, C. E., Close, D. M., Gorb, L., et al. (2007) · The Journal of Physical Chemistry B · doi:10.1021/jp0684224 · Cited by 164 · see citing works
Chromosomal landscape of UV damage formation and repair at single-nucleotide resolution
Mao, P., Smerdon, M. J., Roberts, S. A., & Wyrick, J. J. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1606667113 · Cited by 164 · see citing works
Protein oxidation, UVA and human DNA repair
Karran, P., & Brem, R. (2016) · DNA repair · doi:10.1016/j.dnarep.2016.05.024 · Cited by 163 · see citing works
Garinis, G. A., Mitchell, J. R., Moorhouse, M. J., Hanada, K., de Waard, H., Vandeputte, D., Jans, J. J. M., Brand, K., Smid, M., van der Spek, P. J., et al. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600849 · Cited by 163 · see citing works
The DNA damage spectrum produced by simulated sunlight
Yoon, J., Lee, C.-S., O'Connor, T. R., Yasui, A., & Pfeifer, G. P. (2000) · Journal of Molecular Biology · doi:10.1006/jmbi.2000.3771 · Cited by 163 · see citing works
Boiteux, S., Coste, F., & Castaing, B. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.042 · Cited by 161 · see citing works
Binding of Transcription Factors Creates Hot Spots for UV Photoproducts In Vivo
Pfeifer, G. P., Drouin, R., Riggs, A. D., & Holmquist, G. P. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.4.1798 · Cited by 160 · see citing works
Lucas, R. M., Norval, M., Neale, R. E., Young, A. R., de Gruijl, F. R., Takizawa, Y., & van der Leun, J. C. (2014) · Photochemical & Photobiological Sciences · doi:10.1039/c4pp90033b · Cited by 158 · see citing works
Regulus, P., Duroux, B., Bayle, A., Favier, A. E., Cadet, J., & Ravanat, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706044104 · Cited by 157 · see citing works
Self-citationCourdavault, S., Baudouin, C., Charveron, M., Canguilhem, B., Favier, A., Cadet, J., & Douki, T. (2005) · DNA Repair · doi:10.1016/j.dnarep.2005.05.001 · Cited by 156 · see citing works
Self-citationBesaratinia, A., Synold, T. W., Chen, H.-H., Chang, C., Xi, B., Riggs, A. D., & Pfeifer, G. P. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502311102 · Cited by 156 · see citing works
Bányász, Á., Douki, T., Improta, R., Gustavsson, T., Onidas, D., Vayá, I., Perron, M., & Markovitsi, D. (2012) · Journal of the American Chemical Society · doi:10.1021/ja304069f · Cited by 155 · see citing works
Self-citationHydroxyl-radical-induced oxidation of 5-methylcytosine in isolated and cellular DNA
Madugundu, G. S., Cadet, J., & Wagner, J. R. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku334 · Cited by 153 · see citing works
Self-citationJiang, N., & Taylor, J. (1993) · Biochemistry · doi:10.1021/bi00053a011 · Cited by 150 · see citing works
UVA-induced cyclobutane pyrimidine dimers in DNA: a direct photochemical mechanism?
Mouret, S., Philippe, C., Gracia-Chantegrel, J., Banyasz, A., Karpati, S., Markovitsi, D., & Douki, T. (2010) · Organic & Biomolecular Chemistry · doi:10.1039/b924712b · Cited by 149 · see citing works
Self-citationKozmin, S., Slezak, G., Reynaud-Angelin, A., Elie, C., de Rycke, Y., Boiteux, S., & Sage, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504497102 · Cited by 148 · see citing works
Young, A. R., Chadwick, C. A., Harrison, G. I., Hawk, J. L. M., Nikaido, O., & Potten, C. S. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12349031 · Cited by 147 · see citing works
Courdavault, S., Baudouin, C., Charveron, M., Favier, A., Cadet, J., & Douki, T. (2004) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2004.07.011 · Cited by 145 · see citing works
Self-citationCadet, J., Loft, S. H., Oliński, R., Evans, M. D., Białkowski, K., Wagner, J. R., Dedon, P. C., Möller, P., Greenberg, M. M., & Cooke, M. S. (2012) · Free Radical Research · doi:10.3109/10715762.2012.659248 · Cited by 143 · see citing works
Self-citationNiles, J. C., Wishnok, J. S., & Tannenbaum, S. R. (2001) · Organic Letters · doi:10.1021/ol006993n · Cited by 142 · see citing works
Patrick, M. H. (1977) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1977.tb07355.x · Cited by 141 · see citing works
Perrier, S., Hau, J., Gasparutto, D., Cadet, J., Favier, A., & Ravanat, J.-L. (2006) · Journal of the American Chemical Society · doi:10.1021/ja057656i · Cited by 141 · see citing works
Self-citationCragg, N., Chadwick, C. A., Potten, C. S., Sheehan, J. M., & Young, A. R. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2002.01681.x · Cited by 140 · see citing works
Wang, H., & Kochevar, I. E. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.12.005 · Cited by 139 · see citing works
Mechanisms and Products of Photosensitized Degradation of Nucleic Acids and Related Model Compounds
Cadet, J., Decarroz, C., Wang, S. Y., & Midden, W. R. (1983) · Israel Journal of Chemistry · doi:10.1002/ijch.198300061 · Cited by 138 · see citing works
Self-citationSurjana, D., Halliday, G. M., & Damian, D. L. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt017 · Cited by 138 · see citing works
Bergeron, F., Auvré, F., Radicella, J. P., & Ravanat, J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000193107 · Cited by 137 · see citing works
Measurement of oxidatively generated base damage in cellular DNA
Cadet, J., Douki, T., & Ravanat, J.-L. (2011) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2011.02.004 · Cited by 136 · see citing works
Self-citationAngelov, D., Spassky, A., Berger, M., & Cadet, J. (1997) · Journal of the American Chemical Society · doi:10.1021/ja971728r · Cited by 135 · see citing works
Self-citationStewart, M. S., Cameron, G. S., & Pence, B. C. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12339344 · Cited by 134 · see citing works
Drouin, R., & Therrien, J. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb03213.x · Cited by 134 · see citing works
Oxidation of Guanine in Cellular DNA by Solar UV Radiation: Biological Role†
Douki, T., Perdiz, D., Grof, P., Kuluncsics, Z., Moustacchi, E., Cadet, J., & Sage, E. (1999) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1999.tb07988.x · Cited by 133 · see citing works
Self-citationDNA damage spectra induced by photosensitization
Epe, B. (2011) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05190c · Cited by 133 · see citing works
Human Telomeres Are Hypersensitive to UV-Induced DNA Damage and Refractory to Repair
Rochette, P. J., & Brash, D. E. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000926 · Cited by 133 · see citing works
Modification of DNA bases by photosensitized one-electron oxidation
Douki, T. (1999) · International Journal of Radiation Biology · doi:10.1080/095530099140212 · Cited by 132 · see citing works
Self-citationDouki, T. (2013) · Photochemical & Photobiological Sciences · doi:10.1039/c3pp25451h · Cited by 132 · see citing works
Self-citationMelanin photosensitization and the effect of visible light on epithelial cells
Chiarelli-Neto, O., Ferreira, A. S., Martins, W. K., Pavani, C., Severino, D., Faião-Flores, F., Maria-Engler, S. S., Aliprandini, E., Martinez, G. R., Di Mascio, P., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113266 · Cited by 131 · see citing works
Solar UV Radiation-Induced DNA Bipyrimidine Photoproducts: Formation and Mechanistic Insights
Cadet, J., Grand, A., & Douki, T. (2014) · Topics in current chemistry · doi:10.1007/128_2014_553 · Cited by 130 · see citing works
Self-citationTime-Resolved Study of Thymine Dimer Formation
Marguet, S., & Markovitsi, D. (2005) · Journal of the American Chemical Society · doi:10.1021/ja050648h · Cited by 129 · see citing works
Zhang, X., Rosenstein, B. S., Wang, Y., Lebwohl, M., Mitchell, D. M., & Wei, H. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb01886.x · Cited by 129 · see citing works
Peng, W., & Shaw, B. R. (1996) · Biochemistry · doi:10.1021/bi960001x · Cited by 128 · see citing works
Formation and processing of DNA damage substrates for the hNEIL enzymes
Fleming, A. M., & Burrows, C. J. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.11.030 · Cited by 127 · see citing works
Pyrimidine Bimolecular Photoproducts
Wang, S. Y. (1976) · Elsevier eBooks · doi:10.1016/b978-0-12-734601-4.50012-4 · Cited by 125 · see citing works
Gut, I. G., Wood, P. D., & Redmond, R. W. (1996) · Journal of the American Chemical Society · doi:10.1021/ja9519344 · Cited by 125 · see citing works
Raoul, S., & Cadet, J. (1996) · Journal of the American Chemical Society · doi:10.1021/ja952347l · Cited by 124 · see citing works
Self-citationMitchell, D. L., Jen, J., & Cleaver, J. E. (1991) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1991.tb02084.x · Cited by 123 · see citing works
Early Events in UV Carcinogenesis—DNA Damage, Target Cells and Mutant p53 Foci<sup>†</sup>
De Gruijl, F. R., & Rebel, H. (2008) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2007.00275.x · Cited by 120 · see citing works
Melanocytes are deficient in repair of oxidative DNA damage and UV-induced photoproducts
Wang, H.-T., Choi, B., & Tang, M.-S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005244107 · Cited by 119 · see citing works
Kvam, E., & Tyrrell, R. M. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00653.x · Cited by 118 · see citing works
Inhibition of UVB induced DNA photodamage in mouse epidermis by topically applied alpha-tocopherol
McVean, M. (1997) · Carcinogenesis · doi:10.1093/carcin/18.8.1617 · Cited by 118 · see citing works
Young, A. R., Potten, C. S., Nikaido, O., Parsons, P. G., Boenders, J., Ramsden, J. M., & Chadwick, C. A. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00435.x · Cited by 117 · see citing works
Clingen, P. H., Arlett, C. F., Roza, L., Mori, T., Nikaido, O., & Green, M. H. L. (1995) · PubMed · Cited by 116 · see citing works
Oxidatively generated damage to DNA by UVA radiation in cells and human skin
Cadet, J., & Douki, T. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.51 · Cited by 116 · see citing works
Self-citationUVA and endogenous photosensitizers — the detection of singlet oxygen by its luminescence
Bäumler, W., Regensburger, J., Knak, A., Felgenträger, A., & Maisch, T. (2011) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05142c · Cited by 115 · see citing works
Chadwick, C. A., Potten, C. S., Nikaido, O., Matsunaga, T., Proby, C., & Young, A. R. (1995) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/1011-1344(94)07096-7 · Cited by 114 · see citing works
Taylor, J., Lu, H., & Kotyk, J. J. (1990) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1990.tb01698.x · Cited by 114 · see citing works
The Triplet Energy of Thymine in DNA
Bosca, F., Lhiaubet-Vallet, V., Cuquerella, M. C., Castell, J. V., & Miranda, M. A. (2006) · Journal of the American Chemical Society · doi:10.1021/ja060651g · Cited by 113 · see citing works
Martinez, G. R., Ravanat, J., de Medeiros, M. H. G., Cadet, J., & Mascio, P. D. (2000) · Journal of the American Chemical Society · doi:10.1021/ja0016452 · Cited by 111 · see citing works
Self-citationEndoperoxide formation in a guanosine derivative
Sheu, C., & Foote, C. S. (1993) · Journal of the American Chemical Society · doi:10.1021/ja00075a105 · Cited by 111 · see citing works
Photosensitised pyrimidine dimerisation in DNA
Cuquerella, M. C., Lhiaubet‐Vallet, V., Boscá, F., & Miranda, M. A. (2011) · Chemical Science · doi:10.1039/c1sc00088h · Cited by 109 · see citing works
The impact of skin colour on human photobiological responses
Fajuyigbe, D., & Young, A. R. (2016) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12511 · Cited by 108 · see citing works
Sheu, C., & Foote, C. S. (1995) · Journal of the American Chemical Society · doi:10.1021/ja00129a004 · Cited by 107 · see citing works
Minor contribution of direct ionization to DNA base damage inducedby heavy ions
Douki, T., Ravanat, J.-L., Pouget, J.-P., Testard, I., & Cadet, J. (2006) · International Journal of Radiation Biology · doi:10.1080/09553000600573788 · Cited by 106 · see citing works
Self-citationBanyasz, A., Vayá, I., Changenet-Barret, P., Gustavsson, T., Douki, T., & Markovitsi, D. (2011) · Journal of the American Chemical Society · doi:10.1021/ja110879m · Cited by 106 · see citing works
Self-citation[1] Naphthalene endoperoxides as generators of singlet oxygen in biological media
Pierlot, C., Aubry, J., Briviba, K., Sies, H., & Mascio, P. D. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)19003-2 · Cited by 105 · see citing works
Rapp, A. W., & Greulich, K. O. (2004) · Journal of Cell Science · doi:10.1242/jcs.01355 · Cited by 105 · see citing works
Bykov, V. J. N., Hemminki, K., Sheehan, J. M., & Young, A. R. (1999) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1999.00523.x · Cited by 105 · see citing works
Beak, S.-M., Lee, Y. S., & Kim, J. (2004) · Biochimie · doi:10.1016/j.biochi.2004.06.010 · Cited by 103 · see citing works
UV Laser Photolysis of DNA: Effect of Duplex Stability on Charge-Transfer Efficiency
Douki, T., Angelov, D., & Cadet, J. (2001) · Journal of the American Chemical Society · doi:10.1021/ja016426a · Cited by 100 · see citing works
Self-citation<scp>UV</scp>‐induced<scp>DNA</scp>Damage: The Role of Electronic Excited States
Markovitsi, D. (2016) · Photochemistry and Photobiology · doi:10.1111/php.12533 · Cited by 100 · see citing works
Wischermann, K., Popp, S., Moshir, S., Scharfetter-Kochanek, K., Wlaschek, M., de Gruijl, F., Hartschuh, W., Greinert, R., Volkmer, B., Faust, A., et al. (2008) · Oncogene · doi:10.1038/onc.2008.70 · Cited by 99 · see citing works
UV INDUCED (6‐4) PHOTOPRODUCTS ARE DISTRIBUTED DIFFERENTLY THAN CYCLOBUTANE DIMERS IN NUCLEOSOMES
Gale, J. M., & Smerdon, M. J. (1990) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1990.tb01732.x · Cited by 98 · see citing works
Mechanistic Aspects of Hydration of Guanine Radical Cations in DNA
Rokhlenko, Y., Cadet, J., Geacintov, N. E., & Shafirovich, V. (2014) · Journal of the American Chemical Society · doi:10.1021/ja412471u · Cited by 98 · see citing works
Self-citationDevelopment of a DNA-dosimeter system for monitoring the effects of solar-ultraviolet radiation
Schuch, A. P., da Silva Galhardo, R., de Lima-Bessa, K. M., Schuch, N. J., & Menck, C. F. M. (2009) · Photochemical & Photobiological Sciences · doi:10.1039/b810085c · Cited by 97 · see citing works
Accuracy of Replication Past the T-C (6-4) Adduct
Horsfall, M. J., & Lawrence, C. W. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1006 · Cited by 94 · see citing works
The specificity of UVA-induced DNA damage in human melanocytes
Mouret, S., Forestier, A., & Douki, T. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c1pp05185g · Cited by 94 · see citing works
Self-citationUVA1 is skin deep: molecular and clinical implications
Tewari, A., Grage, M. M.-L., Harrison, G. I., Sarkany, R., & Young, A. R. (2012) · Photochemical & Photobiological Sciences · doi:10.1039/c2pp25323b · Cited by 93 · see citing works
Mouret, S., Charveron, M., Favier, A., Cadet, J., & Douki, T. (2008) · DNA Repair · doi:10.1016/j.dnarep.2008.01.005 · Cited by 92 · see citing works
Self-citationTheoretical Determination of One-Electron Redox Potentials for DNA Bases, Base Pairs, and Stacks
Paukku, Y., & Hill, G. (2011) · The Journal of Physical Chemistry A · doi:10.1021/jp201281t · Cited by 91 · see citing works
Scavenging or Quenching Effect of Melanin on Superoxide Anion and Singlet Oxygen
Tada, M., Kohno, M., & Niwano, Y. (2010) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.09-84 · Cited by 91 · see citing works
Involvement of 5-methylcytosine in sunlight-induced mutagenesis 1 1Edited by J. Karn
You, Y., Li, C., & Pfeifer, G. P. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1999.3174 · Cited by 90 · see citing works
Suschek, C. V., Rothe, H. M., Fehsel, K., et al. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.6.3283 · Cited by 90 · see citing works
Cannistraro, V. J., & Taylor, J. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.07.048 · Cited by 90 · see citing works
Douki, T., Rivière, J., & Cadet, J. (2002) · Chemical Research in Toxicology · doi:10.1021/tx0155909 · Cited by 90 · see citing works
Self-citationOxidative DNA damage and mutations induced by a polar photosensitizer, Ro19-8022
Will, O., Gocke, E., Eckert, I., Schulz, I., Pflaum, M., Mahler, H., & Epe, B. (1999) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(99)00039-7 · Cited by 89 · see citing works
Rijken, F., Bruijnzeel, P. L. B., van Weelden, H., & Kiekens, R. C. M. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22609.x · Cited by 89 · see citing works
Reactive oxygen‐mediated damage to a human DNA replication and repair protein
Montaner, B., O'Donovan, P., Reelfs, O., Perrett, C. M., Zhang, X., Xu, Y., Ren, X., Macpherson, P., Frith, D., & Karran, P. (2007) · EMBO Reports · doi:10.1038/sj.embor.7401084 · Cited by 88 · see citing works
Kinetics of singlet oxygen photosensitization in human skin fibroblasts
Jiménez-Banzo, A., Sagristá, M. L., Mora, M., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.02.011 · Cited by 88 · see citing works
Measurement of Oxidative Damage at Pyrimidine Bases in γ-Irradiated DNA
Douki, T., Delatour, T., Paganon, F., & Cadet, J. (1996) · Chemical Research in Toxicology · doi:10.1021/tx960095b · Cited by 87 · see citing works
Self-citationPelle, E., Mammone, T., MARENUS, K. D., Maes, D. H., Huang, X., & Frenkel, K. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12330.x · Cited by 87 · see citing works
Photochemistry of pheomelanin: Action spectrum for superoxide production
Chedekel, M. R., Agin, P. P., & Sayre, R. M. (1980) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1980.tb03745.x · Cited by 87 · see citing works
In vitro assessments of UVA protection by popular sunscreens available in the United States
Wang, S. Q., Stanfield, J. W., & Osterwalder, U. (2008) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2008.07.043 · Cited by 86 · see citing works
Crean, C. W., Uvaydov, Y., Geacintov, N. E., & Shafirovich, V. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkm1092 · Cited by 86 · see citing works
Poon, T. S. C., Barnetson, R. S., & Halliday, G. M. (2005) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2005.23894.x · Cited by 86 · see citing works
Current challenges in photoprotection.
Lim, H., Arellano-Mendoza, M., & Stengel, F. (2017) · Journal of American Academy of Dermatology · doi:10.1016/j.jaad.2016.09.040 · Cited by 85 · see citing works
Triplet Excited Fluoroquinolones as Mediators for Thymine Cyclobutane Dimer Formation in DNA
Lhiaubet‐Vallet, V., Cuquerella, M. C., Castell, J. V., Boscá, F., & Miranda, M. A. (2007) · The Journal of Physical Chemistry B · doi:10.1021/jp070167f · Cited by 84 · see citing works
Ravanat, J., Sauvaigo, S., Caillat, S., Martinez, G. R., de Medeiros, M. H. G., Mascio, P. D., Favier, A. E., & Cadet, J. (2004) · Biological Chemistry · doi:10.1515/bc.2004.003 · Cited by 84 · see citing works
Self-citationOne-electron oxidation of DNA and inflammation processes
Cadet, J., Douki, T., & Ravanat, J. (2006) · Nature Chemical Biology · doi:10.1038/nchembio0706-348 · Cited by 83 · see citing works
Self-citationTanning in Human Skin Types II and III Offers Modest Photoprotection Against Erythema
Sheehan, J. M., Potten, C. S., & Young, A. R. (1998) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1998.tb02518.x · Cited by 83 · see citing works
High resolution mapping of modified DNA nucleobases using excision repair enzymesPreprint
Bryan, D. S., Ransom, M., Adane, B., York, K. T., & Hesselberth, J. R. (2014) · Genome Research · doi:10.1101/gr.174052.114 · Cited by 82 · see citing works
Lemaire, D. G. E., & Ruzsicska, B. P. (1993) · Biochemistry · doi:10.1021/bi00061a009 · Cited by 81 · see citing works
Photochemistry of cytosine derivatives. 1. Photochemistry of thymidylyl-(3' →5')-deoxycytidine
Liu, F., & Yang, N.-C. C. (1978) · Biochemistry · doi:10.1021/bi00616a003 · Cited by 80 · see citing works
The relative roles of DNA damage induced by UVA irradiation in human cells
Cortat, B., Garcia, C. C. M., Quinet, A., Schuch, A. P., de Lima-Bessa, K. M., & Menck, C. F. M. (2013) · Photochemical & Photobiological Sciences · doi:10.1039/c3pp50023c · Cited by 80 · see citing works
Young, A. R., Sheehan, J. M., Chadwick, C. A., & Potten, C. S. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00012.x · Cited by 79 · see citing works
Ikehata, H., Kawai, K., Komura, J.-I., Sakatsume, K., Wang, L., Imai, M., Higashi, S., Nikaido, O., Yamamoto, K., Hieda, K., et al. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.61 · Cited by 79 · see citing works
In vitro Photooxidation of Nucleic Acids by Ultraviolet A Radiation
Warner, W. G., & Wei, R. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb08605.x · Cited by 79 · see citing works
Flagged first, then by citations
1 of the 346 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- J. Cadet and P. Vigny, in Bioorganic Photochemistry, ed. H. Morrison, Wiley, New York, 1990, pp. 1–272.
Cited by
Sorted by citations
DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging
Tiwari, V., & Wilson, D. M. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.06.005 · Cited by 244 · see citing works
Lucas, R. M., Yazar, S., Young, A. R., Norval, M., de Gruijl, F. R., Takizawa, Y., Rhodes, L. E., Sinclair, C., & Neale, R. Ε. (2019) · Photochemical & Photobiological Sciences · doi:10.1039/c8pp90060d · Cited by 245 · see citing works
Ren, S., Boo, C., Guo, N., et al. (2018) · Environmental Science & Technology · doi:10.1021/acs.est.8b01888 · Cited by 226 · see citing works
Photosensitization Reactions of Biomolecules: Definition, Targets and Mechanisms
Baptista, M. S., Cadet, J., Greer, A., & Thomas, A. H. (2021) · Photochemistry and Photobiology · doi:10.1111/php.13470 · Cited by 205 · see citing works
Self-citationBiological Stability of Water-Based Cutting Fluids: Progress and Application
Tang, L., Zhang, Y., Li, C., Zhou, Z., Nie, X., Chen, Y., Cao, H., Лю, Б., Zhang, N., Said, Z., et al. (2022) · Chinese Journal of Mechanical Engineering · doi:10.1186/s10033-021-00667-z · Cited by 175 · see citing works
“, powerful oxidant materials or photosensitive molecules other than NAs and proteins [190].”
BackgroundBernerd, F., Passeron, T., Castiel, I., & Marionnet, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158243 · Cited by 179 · see citing works
“UVA can also induce the formation of CPDs, as well as a large range of oxidatively generated lesions, such as single strand breaks and oxidized bases [46].”
BackgroundFocus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies
Kciuk, M., Marciniak, B., Mojzych, M., & Kontek, R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197264 · Cited by 168 · see citing works
“In contrast, some studies indicate that the formation of 6-4PPs may have no impact on mutagenesis [15].”
BackgroundInfluentialKim, D. J., Iwasaki, A., Chien, A. L.-L., & Kang, S. (2022) · JCI Insight · doi:10.1172/jci.insight.156344 · Cited by 166 · see citing works
“While the central role of DNA damage is already readily appreciated in skin carcinogenesis (5), it is still unclear whether UVB-induced DNA damage holds any nonredundant roles in inducing MMP expression and driving photoaging.”
BackgroundEffect of UV Irradiation and TiO2-Photocatalysis on Airborne Bacteria and Viruses: An Overview
Bono, N., Ponti, F., Punta, C., & Candiani, G. (2021) · Materials · doi:10.3390/ma14051075 · Cited by 156 · see citing works
“, powerful oxidant materials or photosensitive molecules other than NAs and proteins [41].”
BackgroundSunscreens: A comprehensive review with the application of nanotechnology
Chavda, V. P., Acharya, D., Hala, V., Daware, S., & Vora, L. K. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104720 · Cited by 139 · see citing works
Role of Rad51 and DNA repair in cancer: A molecular perspective
Laurini, E., Marson, D., Fermeglia, A., Aulić, S., Fermeglia, M., & Pricl, S. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107492 · Cited by 128 · see citing works
Boosting the Photoaged Skin: The Potential Role of Dietary Components
Geng, R., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13051691 · Cited by 116 · see citing works
“Cadet, J.; Douki, T. Formation of UV-induced DNA damage contributing to skin cancer development.”
BackgroundInfluentialBio-printing of aligned GelMa-based cell-laden structure for muscle tissue regeneration
Hwangbo, H., Lee, H., Jin, E., Lee, J., Jo, Y., Ryu, D., & Kim, G. (2021) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.06.031 · Cited by 108 · see citing works
“Although cells have natural inbuilt mechanisms to avoid mutagenesis, however, failure of these mechanisms could induce tumorigenesis [26,27].”
Koritala, B. S. C., Porter, K. I., Arshad, O. A., Gajula, R. P., Mitchell, H. D., Arman, T., Manjanatha, M. G., Teeguarden, J., Dongen, H. P. A. V., McDermott, J., et al. (2021) · Journal of Pineal Research · doi:10.1111/jpi.12726 · Cited by 106 · see citing works
Unboxing the molecular modalities of mutagens in cancer
Kumari, S., Sharma, S., Advani, D., Khosla, A., Kumar, P., & Ambasta, R. K. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-16726-w · Cited by 105 · see citing works
“induced damage results in the production of cyclobutane pyrimidine dimers and 6-4 photoproducts that induce CC to TT mutations (Cadet and Douki 2018).”
BackgroundKoklesová, L., Líšková, A., Samec, M., Qaradakhi, T., Zulli, A., Šmejkal, K., Kajo, K., Jakubı́ková, J., Behzadi, P., Péč, M. J., et al. (2020) · The EPMA Journal · doi:10.1007/s13167-020-00210-5 · Cited by 94 · see citing works
Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis
Vogeley, C., Esser, C., Tüting, T., Krutmann, J., & Haarmann‐Stemmann, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20236005 · Cited by 90 · see citing works
UV Radiation in DNA Damage and Repair Involving DNA-Photolyases and Cryptochromes
Vechtomova, Y. L., Telegina, T. A., Buglak, A. A., & Kritsky, M. (2021) · Biomedicines · doi:10.3390/biomedicines9111564 · Cited by 92 · see citing works
Nihemaiti, M., Yoon, Y., He, H., Dodd, M. C., Croué, J., & Lee, Y. (2020) · Water Research · doi:10.1016/j.watres.2020.115921 · Cited by 83 · see citing works
Choi, Y., He, H., Dodd, M. C., & Lee, Y. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.0c05274 · Cited by 83 · see citing works
Arsenic co-carcinogenesis: Inhibition of DNA repair and interaction with zinc finger proteins
Zhou, X., Speer, R. M., Volk, L. B., Hudson, L. G., & Liu, K. J. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.009 · Cited by 88 · see citing works
Singh, A., Čížková, M., Bišová, K., & Vítová, M. (2021) · Antioxidants · doi:10.3390/antiox10050683 · Cited by 83 · see citing works
“Nevertheless, UV-A irradiation can penetrate the dermis of the skin by up to 1 mm and leads to the generation of oxygen free radicals; these cause modifications to DNA bases, specifically 8-oxo-7,8 dihydroguanine, which is directly linked with the development of skin cancer [14,15].”
BackgroundEndogenous Photosensitizers in Human Skin.
Bastos, E., Quina, F., & Baptista, M. S. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00787 · Cited by 69 · see citing works
UVA Radiation, DNA Damage, and Melanoma
Jin, S., Padron, F., & Pfeifer, G. P. (2022) · ACS Omega · doi:10.1021/acsomega.2c04424 · Cited by 83 · see citing works
Photoprotection of the future: Challenges and opportunities
Krutmann, J., Passeron, T., Gilaberte, Y., Granger, C., Leone, G., Narda, M., Schalka, S., Trullas, C., Masson, P., & Lim, H. W. (2020) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.16030 · Cited by 74 · see citing works
Lee, C. Y., O’Connell, C. D., Onofrillo, C., Choong, P., Bella, C. D., & Duchi, S. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.19-0192 · Cited by 70 · see citing works
Significance of melanin distribution in the epidermis for the protective effect against UV light
Zamudio Díaz, D. F., Busch, L., Kröger, M., Klein, A. L., Lohan, S. B., Mewes, K. R., Vierkotten, L., Witzel, C., Rohn, S., & Meinke, M. C. (2024) · Scientific Reports · doi:10.1038/s41598-024-53941-0 · Cited by 71 · see citing works
“This results in the formation of the most ubiquitous DNA lesions—cyclobutane-pyrimidine dimers (CPD) and pyrimidine (6-4)-pyrimidone photoproducts (6-4PP)—along with single chain breaks and 8-oxo-7,8-dihydroguanine (8-oxoGua), respectively 4,5 .”
BackgroundPaul, D., Mu, H., Zhao, H., Ouerfelli, O., Jeffrey, P. D., Broyde, S. B., & Min, J. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz359 · Cited by 62 · see citing works
“Nevertheless, 6-4PP is also cytotoxic and mutagenic although the high mutability of 6-4PP is likely suppressed by rapid repair of the lesion in cells (1,4,12,13).”
Background3D bioprinting: Materials, processes, and applications
Bártolo, P., Malshe, A. P., Ferraris, E., & Koç, B. (2022) · CIRP Annals · doi:10.1016/j.cirp.2022.06.001 · Cited by 69 · see citing works
Yoon, Y., Dodd, M. C., & Lee, Y. (2018) · Environmental Science Water Research & Technology · doi:10.1039/c8ew00200b · Cited by 62 · see citing works
“In the current study, we focused on photon absorbance by TT sites, as they are the most photoreactive for CPD formation amongst the four pyrimidine doublets TT, TC, CT, and CC, and also reported to be the most slowly repaired in human skin cells (Cadet and Douki, 2018).”
Assessing the safety of new germicidal far‐UVC technologies
Görlitz, M., Justen, L. J., Rochette, P. J., Buonanno, M., WELCH, D. F., Kleiman, N. J., Eadie, E., Kaidzu, S., Bradshaw, W. J., Javorsky, E., et al. (2023) · Photochemistry and Photobiology · doi:10.1111/php.13866 · Cited by 65 · see citing works
“35 UV can also indirectly cause DNA damage through excitation of endogenous (e.g. porphyrins, flavins, phe-omelanin) or exogenous (e.g. pollutants, drugs, chemicals) chromophores, 36 which can lead to the formation of reactive species including superoxide anion radicals and singlet oxygen through…”
BackgroundFormation and Recognition of UV-Induced DNA Damage within Genome Complexity
Berens, P. J. T., & Molinier, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186689 · Cited by 59 · see citing works
“Additionally, UV-induced ROS can indirectly lead to base alkylation and DNA–protein or DNA–DNA cross-linking [14,15].”
BackgroundCurrent Advancements and Novel Strategies in the Treatment of Metastatic Melanoma
Sood, S., Jayachandiran, R., & Pandey, S. (2021) · Integrative Cancer Therapies · doi:10.1177/1534735421990078 · Cited by 56 · see citing works
Fujii, J., Soma, Y., & Matsuda, Y. (2023) · Molecules · doi:10.3390/molecules28104085 · Cited by 58 · see citing works
“UVB radiation dominantly causes dimeric pyrimidine photoproducts, while 8-oxoG represents at best 1% of the overall amount of dimeric pyrimidine photoproducts generated by exposure to UVB radiation [96,97].”
BackgroundSpennemann, D. H. R. (2021) · Journal of Green Building · doi:10.3992/jgb.16.1.199 · Cited by 57 · see citing works
“While UV radiation is harmful to humans and has been implicated in cell ageing (Panich et al., 2016) and in the development of malignant skin lesions (Cadet and Douki, 2018, Svobodová and Vostálová, 2010), it is certainly possible to conceptualise UV-C cupboards for external clothing and footwear.”
BackgroundTranscription-coupled nucleotide excision repair: New insights revealed by genomic approaches
Duan, M., Speer, R. M., Ulibarri, J., Liu, K. J., & Mao, P. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103126 · Cited by 51 · see citing works
Hegedűs, C., Juhász, T., Fidrus, E., Janka, E. A., Juhász, G., Boros, G., Paragh, G., Uray, K., Emri, G., Remenyik, É., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101808 · Cited by 57 · see citing works
“(280–315 nm) mostly causes direct DNA damage through the production of intra-strand DNA base cross-linking, including cyclobutane pyrimidine dimers (CPDs) and (6–4) pyrimidine-pyrimidone photoproducts (6–4)PPs] and their Dewar isomers [19].”
BackgroundBacqueville, D., Jacques, C., Dromigny, H., Boyer, F., Brunel, Y., Ferret, P., Redoules, D., Douki, T., Bessou‐Touya, S., & Duplan, H. (2021) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-021-00114-x · Cited by 53 · see citing works
Self-citationBeckmann, A., Hainz, N., Tschernig, T., et al. (2019) · Cancers · doi:10.3390/cancers11030288 · Cited by 51 · see citing works
Guanine Radicals Induced in DNA by Low-Energy Photoionization
Balanikas, E., Bányász, Á., Douki, T., Baldacchino, G., & Markovitsi, D. (2020) · Accounts of Chemical Research · doi:10.1021/acs.accounts.0c00245 · Cited by 51 · see citing works
Self-citationUltraviolet Light Protection: Is It Really Enough?
Farris, P. K., & Valacchi, G. (2022) · Antioxidants · doi:10.3390/antiox11081484 · Cited by 55 · see citing works
“causing the signature mutations cyclobutane pyrimidine dimers (CPDs) and pyrimidine cross-linked dimers [8].”
BackgroundSurgical management of non melanoma skin cancer of the head and neck
Kansara, S., Bell, D., & Weber, R. S. (2019) · Oral Oncology · doi:10.1016/j.oraloncology.2019.104485 · Cited by 49 · see citing works
Gao, W., Yuan, L., Zhang, Y., Huang, F., Gao, F., Li, J., Xu, F., Wang, H., & Wang, Y. (2022) · Photochemical & Photobiological Sciences · doi:10.1007/s43630-022-00304-1 · Cited by 49 · see citing works
“Long-term chronic ultraviolet (UV) radiation induces matrix metalloproteinases (MMPs) increase, oxidative protein damage, telomere shortening, and DNA damage, all of which accelerate skin photoaging, which manifests as coarse wrinkles, dryness, thickness, pigmented spots, and dermal carcinogenesis [1, 2].”
BackgroundSadraeian, M., Zhang, L., Aavani, F., Biazar, E., & Jin, D. (2022) · eLight · doi:10.1186/s43593-022-00029-9 · Cited by 53 · see citing works
“However, on the downside, UV radiation plays a key role in the initiation phase of skin cancer by causing DNA damage [41].”
BackgroundSouto, E. B., da Ana, R., Vieira, V., Fangueiro, J. F., Dias-Ferreira, J., Cano, A. C., Zielińska, A., Silva, A. M., Staszewski, R., & Karczewski, J. (2022) · Neoplasia · doi:10.1016/j.neo.2022.100810 · Cited by 48 · see citing works
Ultraviolet Light Causes Skin Cell Senescence: From Mechanism to Prevention Principle
Song, S., Li, F., Zhao, B., Zhou, M., & Wang, X. (2024) · Advanced Biology · doi:10.1002/adbi.202400090 · Cited by 48 · see citing works
Sunscreen testing: A critical perspective and future roadmap
Zou, W., Ramanathan, R., Urban, S., et al. (2022) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2022.116724 · Cited by 44 · see citing works
Gęgotek, A., Jarocka-Karpowicz, I., & Skrzydlewska, E. (2020) · Nutrients · doi:10.3390/nu12041074 · Cited by 45 · see citing works
“As a result, irreversible oxidative changes in intracellular molecular structures might be observed, as is seen in the case of nucleic acids, which causes DNA mutations and lead to the development of skin cancers [4,5].”
BackgroundLi, C., Ma, W., & Ren, X. (2019) · Fibers and Polymers · doi:10.1007/s12221-019-8722-5 · Cited by 41 · see citing works
CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma
Houlès, T., Lavoie, G., Nourreddine, S., Cheung, W., Vaillancourt-Jean, É., Guérin, C. M., Bouttier, M., Grondin, B., Lin, S., Saba-El-Leil, M. K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34179-8 · Cited by 40 · see citing works
Nanotechnology as a Promising Method in the Treatment of Skin Cancer
Adamus-Grabicka, A. A., Hikisz, P., & Sikora, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042165 · Cited by 41 · see citing works
Fajuyigbe, D., Douki, T., van Dijk, A., Sarkany, R. P. E., & Young, A. R. (2021) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12956 · Cited by 39 · see citing works
“The thymine cyclobutane dimer (TT-CPD) is the most common lesion (Cadet & Douki, 2018).”
BackgroundSelf-citationDas, D., Bordoloi, A., Achary, M. P., Caldwell, D. J., & Suri, R. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.155205 · Cited by 40 · see citing works
Baptista, M. S., Cadet, J., Greer, A., & Thomas, A. H. (2022) · Photochemistry and Photobiology · doi:10.1111/php.13774 · Cited by 41 · see citing works
“Singlet oxygen ((1)O2) that is the only ROS produced by type II photosensitization reacts exclusively with guanine among DNA components (152,153).”
BackgroundSelf-citationBacqueville, D., Jacques-Jamin, C., Lapalud, P., Douki, T., Roullet, N., Sereno, J., Redoules, D., Bessou-Touya, S., & Duplan, H. (2022) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.18196 · Cited by 40 · see citing works
Self-citationPhotoinduced intersystem crossing in DNA oxidative lesions and epigenetic intermediates
Francés‐Monerris, A., Lineros‐Rosa, M., Miranda, M. A., Lhiaubet‐Vallet, V., & Monari, A. (2020) · Chemical Communications · doi:10.1039/d0cc01132k · Cited by 36 · see citing works
Comprehensive Study of Guanine Excited State Relaxation and Photoreactivity in G-quadruplexes
Martínez‐Fernández, L., Changenet‐Barret, P., Bányász, Á., Gustavsson, T., Markovitsi, D., & Improta, R. (2019) · The Journal of Physical Chemistry Letters · doi:10.1021/acs.jpclett.9b02740 · Cited by 36 · see citing works
Holt, E. L., & Stavros, V. G. (2019) · International Reviews in Physical Chemistry · doi:10.1080/0144235x.2019.1663062 · Cited by 34 · see citing works
Propolis inspired sunscreens for efficient UV-protection and skin barrier maintenance
Fu, Y., Wan, R.-Y., Yang, L., Xiong, L., Hu, J., Tang, J., He, H.-L., Gu, Z.-P., Li, L., & Li, Y.-W. (2022) · Nano Reseach · doi:10.1007/s12274-022-4434-z · Cited by 32 · see citing works
Ultraviolet radiation and cutaneous melanoma: a historical perspective
Autier, P., & Doré, J. (2020) · Melanoma research · doi:10.1097/cmr.0000000000000609 · Cited by 33 · see citing works
Behind the Scene: Exploiting MC1R in Skin Cancer Risk and Prevention
Manganelli, M., Guida, S., Ferretta, A., Pellacani, G., Porcelli, L., Azzariti, A., & Guida, G. (2021) · Genes · doi:10.3390/genes12071093 · Cited by 37 · see citing works
Dutta, B. J., Rakshe, P. S., Maurya, N., Chib, S., & Singh, S. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102125 · Cited by 37 · see citing works
Rutin Protects Fibroblasts from UVA Radiation through Stimulation of Nrf2 Pathway
Tabolacci, E., Tringali, G., Nobile, V., Duca, S., Pizzoferrato, M., Bottoni, P., & Clementi, M. E. (2023) · Antioxidants · doi:10.3390/antiox12040820 · Cited by 33 · see citing works
Lu, C. H., Gutierrez‐Bayona, N. E., & Taylor, J. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab214 · Cited by 33 · see citing works
“UVC (200–290 nm), UVB (290–320 nm) and UVA (320– 400 nm) give rise to CPDs via direct excitation of DNA (2,12,14).”
MethodUme, A. C., Pugh, J. M., Kemp, M. G., & Williams, C. R. (2020) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12600 · Cited by 33 · see citing works
A perspective review on impact and molecular mechanism of environmental carcinogens on human health
Malik, S., Prasad, S., Kishore, S., Kumar, A., & Upadhyay, V. (2021) · Biotechnology and Genetic Engineering Reviews · doi:10.1080/02648725.2021.1991715 · Cited by 31 · see citing works
The key role of UVA-light induced oxidative stress in human Xeroderma Pigmentosum Variant cells
Moreno, N. C., Garcia, C. C. M., Munford, V., Rocha, C. R. R., Pelegrini, A. L., Corradi, C., Sarasin, A. R., & Menck, C. F. M. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.12.012 · Cited by 32 · see citing works
Radiofrequency Radiation and Cancer
Grimes, D. R. (2021) · JAMA Oncology · doi:10.1001/jamaoncol.2021.5964 · Cited by 32 · see citing works
Ying, S., & Khaperskyy, D. A. (2020) · Journal of Cell Science · doi:10.1242/jcs.248310 · Cited by 32 · see citing works
Atomic layer deposition paves the way for next-generation smart and functional textiles
Qiao, S., Shi, Z., Tong, A., et al. (2025) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2025.103500 · Cited by 31 · see citing works
Douki, T. (2020) · Photochemistry and Photobiology · doi:10.1111/php.13278 · Cited by 32 · see citing works
“target of those type-I photosensitization processes that involve electron abstraction from DNA (30,63,66).”
BackgroundInfluentialSelf-citationGary, A.-S., & Rochette, P. J. (2020) · Scientific Reports · doi:10.1038/s41598-020-75873-1 · Cited by 30 · see citing works
Jandova, J., Snell, J., Hua, A., Dickinson, S., Fimbres, J., & Wondrak, G. T. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102042 · Cited by 30 · see citing works
DNA damage in cancer development: special implications in viral oncogenesis.
Katerji, M., & Duerksen-Hughes, P. J. (2021) · PubMed Central · Cited by 29 · see citing works
Nozza, E., Melzi, G., Marabini, L., Marinovich, M., Piazza, S., Khalilpour, S., Dell’Agli, M., & Sangiovanni, E. (2020) · Antioxidants · doi:10.3390/antiox9040292 · Cited by 30 · see citing works
Biphotonic Ionization of DNA : From Model Studies to Cell
Cadet, J., Wagner, J. R., & Angelov, D. (2018) · Photochemistry and Photobiology · doi:10.1111/php.13042 · Cited by 29 · see citing works
Self-citationPerer, J., Jandová, J., Fimbres, J., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101594 · Cited by 27 · see citing works
UV irradiation remodels the specificity landscape of transcription factors
Mielko, Z. E., Zhang, Y., Sahay, H., Liu, Y., Schaich, M. A., Schnable, B. L., Morrison, A. M., Burdinski, D., Adar, S., Pufall, M. A., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2217422120 · Cited by 23 · see citing works
“1A), with the most common being the formation of cyclobutane pyrimidine dimers (CPD) and 6-4 photoproducts (6-4PP) at pyrimidine dinucleotides (3).”
BackgroundCurrent aspects of DNA damage and repair in ecotoxicology: a mini-review
Costa, P. M. (2021) · Ecotoxicology · doi:10.1007/s10646-021-02487-2 · Cited by 27 · see citing works
Contribution of oxidation reactions to photo‐induced damage to cellular DNA
Cadet, J., Angelov, D., Mascio, P. D., & Wagner, J. R. (2024) · Photochemistry and Photobiology · doi:10.1111/php.13990 · Cited by 27 · see citing works
“As an indication of the ability for UVB to induce oxidation reactions in cellular DNA, the formation of 8-oxodGuo was measured initially by HPLC-ECD and subsequently by HPLC-MS/MS (for earlier reviews, see [33,40] and references herein).”
Self-citationDunn, F. B., & Silverman, A. I. (2021) · Environmental Science & Technology · doi:10.1021/acs.est.1c00732 · Cited by 28 · see citing works
Nagapan, T. S., Ghazali, A. R., Basri, D. F., & Lim, W. N. (2018) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/1481 · Cited by 27 · see citing works
Fraikin, G. Y., Belenikina, N. S., & Rubin, A. B. (2024) · Molecular Biology · doi:10.1134/s0026893324010047 · Cited by 29 · see citing works
“However, while UVB-induced dimers involve both thymine and cytosine bases, UVA induces mostly T-containing dimers and does not cause 6-4PPs [3].”
InfluentialGsell, C., Richly, H., Coin, F., & Naegeli, H. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz1229 · Cited by 26 · see citing works
Sanjaya, S. S., Park, M. H., Karunarathne, W. A. H. M., Lee, K. T., Choi, Y. H., Kang, C., Lee, M.-H., Jung, M.-J., Ryu, H. W., & Kim, G. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155442 · Cited by 27 · see citing works
Supp, D. M., Hahn, J. M., Lloyd, C. M., Combs, K. A., Swope, V. B., ABDEL‐MALEK, Z. A., & Boyce, S. T. (2020) · Journal of Burn Care & Research · doi:10.1093/jbcr/iraa029 · Cited by 26 · see citing works
The Action Spectra of the Visible Light Phototoxicity in Keratinocytes
Tonolli, P. N., Palomino, C. M. V., Junqueira, H. C., & Baptista, M. S. (2022) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2023.112703 · Cited by 25 · see citing works
Mo, Q., You, S., Fu, H., Wang, D., Zhang, J., Wang, C., & Li, M. (2022) · Antioxidants · doi:10.3390/antiox11122333 · Cited by 25 · see citing works
Ratycz, M., Lender, J. A., & Gottwald, L. (2019) · Case Reports in Dermatology · doi:10.1159/000503273 · Cited by 23 · see citing works
Portillo-Esnaola, M., Rodríguez-Luna, A., Morala, J. N., Gallego-Rentero, M., Villalba, M., Juarranz, Á., & González, S. (2021) · Antioxidants · doi:10.3390/antiox10121961 · Cited by 23 · see citing works
“It consists in the formation of CPDs after UVR exposure as a result of chemiexcitation [4].”
BackgroundWendland, R. J., Conway, M. T., & Worthington, K. S. (2024) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37715 · Cited by 22 · see citing works
Tao, K., Guo, L., Hu, X., Fitzgerald, C., Rouzard, K., Healy, J., Tamura, M., Stock, J. B., Stock, M. B., Pérez, E., et al. (2021) · Cosmetics · doi:10.3390/cosmetics9010004 · Cited by 25 · see citing works
“Two common markers for measuring UVB-induced damage are cyclobutene pyrimidine dimers (CPDs) and sunburn cells (SBCs) [35,36].”
BackgroundRas-Mediated Activation of NF-κB and DNA Damage Response in Carcinogenesis
Ahmad, A., & Ahsan, H. (2020) · Cancer Investigation · doi:10.1080/07357907.2020.1721523 · Cited by 23 · see citing works
Beyond Traditional Sunscreens: A Review of Liposomal-Based Systems for Photoprotection
Miranda, J. A., da Cruz, Y. F., Girão, Í. C., de Souza, F. J. J., de Oliveira, W. N., Alencar, É. D. N., Amaral-Machado, L., & do Egito, E. S. T. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16050661 · Cited by 23 · see citing works
“Ultraviolet (UV) radiation is one of the main contributing factors for skin damage due to its ability to cross the ozone layer [1].”
BackgroundPerovskite quantum dots growth in situ in transparent medium for short wavelength shielding
Yang, Z., Zhao, L., Li, M., et al. (2020) · Journal of the American Ceramic Society · doi:10.1111/jace.17132 · Cited by 22 · see citing works
A half century of exploring DNA excision repair in chromatin
Smerdon, M. J., Wyrick, J. J., & Delaney, S. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105118 · Cited by 23 · see citing works
“In addition, the overall levels of (6–4) PPs in UV-irradiated chromatin are significantly less than that of CPDs (61).”
BackgroundGoyer, B., Pereira, U., Magne, B., Larouche, D., Kearns‐Turcotte, S., Rochette, P. J., Martin, L., & Germain, L. (2019) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2959 · Cited by 23 · see citing works
“The cyclobutane pyrimidine dimer (CPD) is the most common DNA photolesion (approximatively 70–80%), whereas pyrimidine (6-4) pyrimidone photoproduct (6-4PP) and Dewar photoproduct (DewarPP) account for less than 20% (Cadet & Douki, 2018).”
BackgroundUVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma
Bowman, R. L., Hennessey, R. C., Tallman, D., Weiss, T. J., Crawford, E. R., Murphy, B., Webb, A., Zhang, S., Perle, K. M. D. L., Burd, C. J., et al. (2021) · Life Science Alliance · doi:10.26508/lsa.202101135 · Cited by 24 · see citing works
“These dosing schemes approximate sun exposures of a similar duration, as the UVB to UVA ratio in sunlight is ~1:20, but varies based on season, cloud cover, and latitude (Cadet & Douki, 2018).”
Mechanism of lesion verification by the human XPD helicase in nucleotide excision repair
Fu, I., Mu, H., Geacintov, N. E., & Broyde, S. B. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac496 · Cited by 20 · see citing works
“Among these, the pyrimidine (6−4) pyrimidone photoproduct (6−4PP) is notable because it is well repaired in cells (4,12,14,15), while the cyclobutane pyrimidine dimer (CPD) that is generated in several-fold greater amount than 6−4PP (16,17) is poorly repaired (18–22).”
BackgroundPhotoprotection by clothing: A review
Boothby‐Shoemaker, W., Mohammad, T. F., Ozog, D., & Lim, H. W. (2022) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12776 · Cited by 21 · see citing works
- Authors
- Cadet, J., & Douki, T.
- Affiliations
- Université de Sherbrooke (CA)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Cadet, Jean
- Douki, Thierry
- Venue
- Photochemical & Photobiological Sciences
- Published
- 2018-12
- Volume
- 17
- Issue
- 12
- Pages
- 1816-1841
- ISSN
- 1474-905X (ISSN-L)
- 1474-9092
- OpenAlex
- W2784555568
- Cited by
- 435
- References
- 346
- Citations by year
- 2026: 47 · 2025: 41 · 2024: 41 · 2023: 62 · 2022: 83 · 2021: 65 · 2020: 49 · 2019: 38 · 2018: 9
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Photochemical & Photobiological Sciences (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Keywords
- UV-induced DNA damage, skin cancer, cyclobutane pyrimidine dimers, 6-4 pyrimidone photoproducts, 8-oxo-7,8-dihydroguanine, UVA, UV-B radiation, DNA photoproducts, mutational signatures, DNA repair, photoprotection, apoptosis, proto-oncogenes, tumor suppressor, DNA strand breaks
- MeSH terms
- Proto-Oncogene Mas, Animals, DNA Damage, DNA Repair, Guanine, Humans, Melanins, Pyrimidine Dimers, Skin Neoplasms, Ultraviolet Rays, DNA Adducts
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review