The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
ACTH Receptors in the Adrenal: Specific Binding of ACTH- 125 I and Its Relation to Adenyl Cyclase
Open accessAbstract
Pure monoiodo ACTH- 125 I was prepared that was biologically active and free of unlabeled ACTH. Extracts of adrenal cortex that contained ACTH-sensitive adenyl cyclase, bound ACTH- 125 I; extracts that lacked the ACTH-sensitive cyclase did not bind ACTH- 125 I. Unlabeled ACTH inhibited the binding of ACTH- 125 I. Five ACTH derivatives which varied widely in biological activity were tested. All inhibited the binding of ACTH- 125 I in direct proportion to their biological activity. Albumin, insulin, and four unrelated iodinated hormones were inert. The addition of excess hormone or acetic acid produced rapid dissociation of bound ACTH- 125 I. This study demonstrates directly the binding of ACTH to its biologically significant site.
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Cites
Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity
HUNTER, W. M., & GREENWOOD, F. C. (1962) · Nature · doi:10.1038/194495a0 · Cited by 6,919
Spectroscopic Determination of Tryptophan and Tyrosine in Proteins*
Edelhoch, H. (1967) · Biochemistry · doi:10.1021/bi00859a010 · Cited by 3,436
Radioimmunoassay of ACTH in plasma
Berson, S. A., & Yalow, R. S. (1968) · Journal of Clinical Investigation · doi:10.1172/jci105955 · Cited by 461
Birnbaumer, L., & Rodbell, M. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)83396-8 · Cited by 354
The Activation of Adrenal Phosphorylase by the Adrenocorticotropic Hormone
Haynes, R. C. (1958) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77372-4 · Cited by 341
Yasumura, Y., Buonassisi, V., & SATO, G. H. (1966) · PubMed · Cited by 276
BINDING OF HORMONE TO TISSUE: THE FIRST STEP IN POLYPEPTIDE HORMONE ACTION
Pastan, I., Roth, J., & Macchia, V. (1966) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.56.6.1802 · Cited by 168
Self-citationStudies on the Adrenocorticotropic Hormone-activated Adenyl Cyclase of a Functional Adrenal Tumor
Taunton, O. D., Roth, J., & Pastan, I. H. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94425-x · Cited by 120
Self-citationIzzo, J. L., Roncone, A. M., Izzo, M. J., & Bale, W. F. (1964) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)91199-3 · Cited by 93
Birmingham, M. K., & Kurlents, E. (1958) · Endocrinology · doi:10.1210/endo-62-1-47 · Cited by 74
Cited by
Gavin, J. R., Roth, J., Neville, D. M., De Meyts, P., & Buell, D. N. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.1.84 · Cited by 1,040
Self-citationOyola, M. G., & Handa, R. J. (2017) · Stress · doi:10.1080/10253890.2017.1369523 · Cited by 710
Freychet, P., Roth, J., & Neville, D. M. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.8.1833 · Cited by 498
Self-citationMembrane Receptors and Hormone Action
Cuatrecasas, P., & Hollenberg, M. D. (1976) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60481-7 · Cited by 478
The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver
Rodbell, M., Krans, H. M. J., Pohl, S. L., & Birnbaumer, L. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62388-9 · Cited by 473
Metadata
- Authors
- Lefkowitz, R. J., Roth, J., Pricer, W., & Pastan, I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1970-03
- Volume
- 65
- Issue
- 3
- Pages
- 745-752
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2095531811
- Cited by
- 305
- References
- 13
- FWCI
- 14.25
- Type
- journal article
- Language
- en
- Open access
- green
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- Lefkowitz, R. J., Roth, J., Pricer, W., & Pastan, I. (1970). ACTH Receptors in the Adrenal: Specific Binding of ACTH- 125 I and Its Relation to Adenyl Cyclase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.65.3.745
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
