The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture
Open accessAbstract
Chronic (5-16 hr) exposure of cultured human lymphocytes to 10 -8 M insulin at 37° in vitro produced a decrease in insulin receptor concentrations unaccounted for by simple occupancy of sites; acute exposure (0-2 hr) was without effect. These results reproduced observations in vivo where chronic hyperinsulinemia (e.g., 10 -8 M insulin in the circulation of obese insulinresistant hyperglycemic mice) is associated with a substantial reduction in the concentration of insulin receptors per cell, while acute hyperinsulinemia in vivo has no effect on receptor concentration. These data suggest a reciprocal relationship between insulin in the extracellular fluid and the concentration of insulin receptors per cell, which is mediated at the target cell itself by intracellular insulin-sensitive regulatory processes and directly affects target-cell sensitivity to hormone.
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Citations
Cites
Olefsky, J., Farquhar, J. W., & Reaven, G. (1973) · Diabetes · doi:10.2337/diab.22.7.507 · Cited by 179
Effect of diet composition on the hyperinsulinemia of obesity
Grey, N., & Kipnis, D. M. (1971) · New England Journal of Medicine · doi:10.1056/nejm197110072851504 · Cited by 156
Cited by
Belchetz, P. E., Plant, T. M., Nakai, Y., Keogh, E. J., & Knobil, E. (1978) · Science · doi:10.1126/science.100883 · Cited by 1,385
Insulin Resistance and Hyperinsulinemia
Shanik, M. H., Xu, Y., Škrha, J., Dankner, R., Zick, Y., & Roth, J. (2008) · Diabetes Care · doi:10.2337/dc08-s264 · Cited by 791
Self-citationBiochemical and cellular properties of insulin receptor signalling
Haeusler, R. A., McGraw, T. E., & Accili, D. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.89 · Cited by 739
Effect of Growth Hormone on Carbohydrate and Lipid Metabolism
DAVIDSON, M. B. (1987) · Endocrine Reviews · doi:10.1210/edrv-8-2-115 · Cited by 573
Membrane Receptors and Hormone Action
Cuatrecasas, P., & Hollenberg, M. D. (1976) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60481-7 · Cited by 478
Metadata
- Authors
- Gavin, J. R., Roth, J., Neville, D. M., De Meyts, P., & Buell, D. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1974-01
- Volume
- 71
- Issue
- 1
- Pages
- 84-88
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2080513099
- Cited by
- 1,040
- References
- 2
- FWCI
- 22.42
- Type
- journal article
- Language
- en
- Open access
- green
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- Gavin, J. R., Roth, J., Neville, D. M., De Meyts, P., & Buell, D. N. (1974). Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.71.1.84
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
