The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Isolation of a Calcium-Sequestering Protein from Sarcoplasmic Reticulum
Open accessAbstract
An acidic protein has been extracted from sarcoplasmic reticulum with KCl and deoxycholate. The protein, which remains soluble after extraction, has been highly purified by fractionation on DEAE-cellulose, Sephadex, and hydroxylaptite. It has a molecular weight of 44,000 and contains 392 amino acid residues per molecule, of which 146 are either glutamic or aspartic acid. No phosphorus, sialic acid, or lipid has been detected in the preparation. The protein has been shown to bind up to 970 nmol of Ca ++ per mg (43 mol/mol) at pH 7.5, with an apparent dissociation constant of 4 × 10 -5 M. Preliminary data indicate that the protein is unique to sarcoplasmic reticulum and that it is hydrophobically bonded on the interior of these vesicles. The protein is believed to play a role in sequestering calcium within sarcoplasmic reticulum. The name Calsequestrin is suggested for the protein.
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Intrinsically disordered protein
Dunker, A. K., Lawson, J. D., Brown, C. J., Williams, R. M., Romero, P., Oh, J. S., Oldfield, C. J., Campen, A. M., Ratliff, C. M., Hipps, K. W., et al. (2001) · Journal of Molecular Graphics and Modelling · doi:10.1016/s1093-3263(00)00138-8 · Cited by 2,272
Alterations of Sarcoplasmic Reticulum Proteins in Failing Human Dilated Cardiomyopathy
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Enjoy the Trip: Calcium in Mitochondria Back and Forth
De Stefani, D., Rizzuto, R., & Pozzan, T. (2016) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034216 · Cited by 423
Modulation of the Ryanodine Receptor and Intracellular Calcium
Zalk, R., Lehnart, S. E., & Marks, A. R. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.053105.094237 · Cited by 371
Yáñez, M., Gil-Longo, J., & Campos-Toimil, M. (2012) · Advances in Experimental Medicine and Biology · doi:10.1007/978-94-007-2888-2_19 · Cited by 195
Metadata
- Authors
- MacLennan, D. H., & Wong, P. T. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1971-06
- Volume
- 68
- Issue
- 6
- Pages
- 1231-1235
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2007709380
- Cited by
- 567
- References
- 16
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- green
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- MacLennan, D. H., & Wong, P. T. S. (1971). Isolation of a Calcium-Sequestering Protein from Sarcoplasmic Reticulum. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.68.6.1231
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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