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Strychnine Binding Associated with Glycine Receptors of the Central Nervous System
Open accessAbstract
[ 3 H]Strychnine binds to synaptic-membrane fractions of the spinal cord in a selective fashion, indicating an interaction with postsynaptic glycine receptors. Displacement of strychnine by glycine and other amino acids parallels their glycine-like neurophysiologic activity. The regional localization of strychnine binding in the central nervous system correlates closely with endogenous glycine concentrations. In subcellular fractionation experiments, strychnine binding is most enhanced in synaptic-membrane fractions. Strychnine binding is saturable, with affinity constants for glycine and strychnine of 10 and 0.03 μM, respectively.
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Cited by
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Jentsch, T. J., Stein, V., Weinreich, F., & Zdebik, A. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00029.2001 · Cited by 1,256
Gamma-Aminobutyric Acid Binding to Receptor Sites in the Rat Central Nervous System
zukin, S. R., Young, A. B., & Snyder, S. H. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.12.4802 · Cited by 580
Self-citationMembrane Receptors and Hormone Action
Cuatrecasas, P., & Hollenberg, M. D. (1976) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60481-7 · Cited by 478
Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases
Alves, A., Bassot, A., Bulteau, A.-L., Pirola, L., & Morio, B. (2019) · Nutrients · doi:10.3390/nu11061356 · Cited by 365
Liu, Q. R., López-Corcuera, B., Mandiyan, S., Nelson, H., & Nelson, N. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41598-0 · Cited by 277
Metadata
- Authors
- Young, A. B., & Snyder, S. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1973-10
- Volume
- 70
- Issue
- 10
- Pages
- 2832-2836
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2043697771
- Cited by
- 388
- References
- 0
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Young, A. B., & Snyder, S. H. (1973). Strychnine Binding Associated with Glycine Receptors of the Central Nervous System. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.70.10.2832
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