The DOI matches its Crossref record; 153 of the 153 references it cites were found in a registry or an index.
Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases
Open accessAbstract
Glycine is the proteinogenic amino-acid of lowest molecular weight, harboring a hydrogen atom as a side-chain. In addition to being a building-block for proteins, glycine is also required for multiple metabolic pathways, such as glutathione synthesis and regulation of one-carbon metabolism. Although generally viewed as a non-essential amino-acid, because it can be endogenously synthesized to a certain extent, glycine has also been suggested as a conditionally essential amino acid. In metabolic disorders associated with obesity, type 2 diabetes (T2DM), and non-alcoholic fatty liver disease (NAFLDs), lower circulating glycine levels have been consistently observed, and clinical studies suggest the existence of beneficial effects induced by glycine supplementation. The present review aims at synthesizing the recent advances in glycine metabolism, pinpointing its main metabolic pathways, identifying the causes leading to glycine deficiency—especially in obesity and associated metabolic disorders—and evaluating the potential benefits of increasing glycine availability to curb the progression of obesity and obesity-related metabolic disturbances. This study focuses on the importance of diet, gut microbiota, and liver metabolism in determining glycine availability in obesity and associated metabolic disorders.
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Cites
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Metadata
- Authors
- Alves, A., Bassot, A., Bulteau, A.-L., Pirola, L., & Morio, B.
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2019-06-16
- Volume
- 11
- Issue
- 6
- Pages
- 1356
- ISSN
- 2072-6643 (ISSN-L)
- OpenAlex
- W2950542148
- Cited by
- 365
- References
- 153
- FWCI
- 11.77
- Type
- journal article
- Language
- en
- Open access
- gold
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- Alves, A., Bassot, A., Bulteau, A.-L., Pirola, L., & Morio, B. (2019). Glycine Metabolism and Its Alterations in Obesity and Metabolic Diseases. Nutrients. https://doi.org/10.3390/nu11061356
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
