The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Aminoglycoside Antibiotic-Inactivating Enzymes in Actinomycetes Similar to Those Present in Clinical Isolates of Antibiotic-Resistant Bacteria
Open accessAbstract
Various species of Streptomyces possess aminoglycoside-modifying enzymes. Streptomyces kanamyceticus contains an enzyme that acetylates the 6′-amino group of kanamycin A and B, gentamicin C 1a , and neomycin. Streptomyces spectabilis produces an enzyme that acetylates the 2′-amino group of the hexose ring of gentamicin C 1a . These enzymes catalyze reactions identical to those catalyzed by enzymes found in gram-negative bacteria containing R(antibiotic resistance)-factors. The discovery of these enzymes suggests the possibility of an evolutionary relationship between the aminoglycosideinactivating enzymes (produced by resistance determinants) in bacteria containing R-factors and similar enzymes found in the actinomycetes.
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Cites
Cohen, S. N., Chang, A. C. Y., & Hsu, L. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.8.2110 · Cited by 2,699
RECOVERY OF RESISTANCE FACTORS FROM A DRUG-FREE COMMUNITY
Gurney, J. M., Gardner, P., Smith, D., et al. (1970) · The Lancet · doi:10.1016/s0140-6736(70)90664-1 · Cited by 62
Cited by
Origins and evolution of antibiotic resistance
Davies, J., & Davies, D. (2010) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00016-10 · Cited by 5,784
Self-citationChopra, I., & Roberts, M. (2001) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.65.2.232-260.2001 · Cited by 4,517
Call of the wild: antibiotic resistance genes in natural environments
Allen, H. K., Donato, J., Wang, H. H., Cloud-Hansen, K. A., Davies, J., & Handelsman, J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2312 · Cited by 2,361
Self-citationMartínez, J. L. (2012) · Frontiers in Microbiology · doi:10.3389/fmicb.2012.00001 · Cited by 2,101
The shared antibiotic resistome of soil bacteria and human pathogens
Forsberg, K. J., Reyes, A., Wang, B., Selleck, E. M., Sommer, M. O. A., & Dantas, G. (2012) · Science · doi:10.1126/science.1220761 · Cited by 1,650
Metadata
- Authors
- Benveniste, R., & Davies, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1973-08
- Volume
- 70
- Issue
- 8
- Pages
- 2276-2280
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2076683150
- Cited by
- 507
- References
- 2
- FWCI
- 6.28
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Aminoglycoside Antibiotic-Inactivating Enzymes in Actinomycetes Similar to Those Present in Clinical Isolates of Antibiotic-Resistant Bacteria. https://app.cochat.ai/papers/10.1073/pnas.70.8.2276
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- Benveniste, R., & Davies, J. (1973). Aminoglycoside Antibiotic-Inactivating Enzymes in Actinomycetes Similar to Those Present in Clinical Isolates of Antibiotic-Resistant Bacteria. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.70.8.2276
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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