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Cited by 156Diet and metabolism studiesDiet, Metabolism, and DiseaseDiabetes, Cardiovascular Risks, and Lipoproteins

Effect of diet composition on the hyperinsulinemia of obesity

Grey, Neil, Kipnis, David M.·1971·New England Journal of Medicine
DOI 10.1056/nejm197110072851504
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Abstract

During two successive three-week periods, seven obese subjects were fed isocaloric diets, the first low, the second high in carbohydrate. In all, basal plasma insulin levels decreased 50 per cent on the low-carbohydrate diet and increased on the high-carbohydrate diet. Three obese subjects were fed, during three successive four-week periods, 1500-calorie diets with high, then low, and then high-carbohydrate content. Basal plasma insulin levels were significantly reduced on the low-carbohydrate diet. Refeeding of the high-carbohydrate diet, despite continued weight loss, resulted in markedly increased basal plasma insulin. In both protocols, most patients also exhibited a decreased insulin secretory response to oral glucose when on a low intake of carbohydrate and an increased response on a high intake. Thus the hyperinsulinemia characteristic of obesity may be a result, in part, of dietary factors rather than exclusively a consequence of the insulin antagonism associated with obesity.

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Crossref · 10.1056/nejm197110072851504

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25 of 25 references verified0 citation errors · 0 not checkable

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  • The actions of carbohydrate on metabolism persist well beyond the postprandial state, as demonstrated by the second meal effect and the effect of a low-carbohydrate diet on fasting insulin.

    “the actions of carbohydrate on metabolism persist well beyond the postprandial state, as demonstrated by the “second meal effect,” wherein the GI of supper influences glucose tolerance the next day (161, 162), and by the effect of a low-carbohydrate diet on fasting insulin (163).”

    From The carbohydrate-insulin model: A physiological perspective on the obesity pandemic (2021) · cites this paper as [163]

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Authors
Grey, N., & Kipnis, D. M.
Affiliations
Washington University in St. Louis (US)
Venue
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Published
1971-10-07
Volume
285
Issue
15
Pages
827-831
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
DOI
10.1056/nejm197110072851504
OpenAlex
W2022580993
Cited by
156
References
25
Citations by year
2026: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2017: 1 · 2016: 1 · 2014: 2
FWCI
12.72
Type
journal article
Language
en
Open access
closed
Locations
  • New England Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Diet and metabolism studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
hyperinsulinemia, obesity, diet composition, carbohydrate intake, low-carbohydrate diet, high-carbohydrate diet, insulin secretion, oral glucose tolerance, refeeding, weight loss
MeSH terms
Insulin Secretion, Adolescent, Adult, Blood Glucose, Diet, Reducing, Dietary Carbohydrates, Female, Humans, Hyperinsulinism, Insulin, Insulin Resistance, Obesity

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