Biochemical and cellular properties of insulin receptor signalling

Haeusler, Rebecca A.; McGraw, Timothy E.; Accili, Domenico

doi:10.1038/nrm.2017.89

Cited by 742Metabolism, Diabetes, and CancerPancreatic function and diabetesDiabetes, Cardiovascular Risks, and Lipoproteins

Biochemical and cellular properties of insulin receptor signalling

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Haeusler, Rebecca A., McGraw, Timothy E., Accili, Domenico·2018·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm.2017.89PMC PMC5894887

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Abstract

The mechanism of insulin action is a central theme in biology and medicine. In addition to the rather rare condition of insulin deficiency caused by autoimmune destruction of pancreatic β-cells, genetic and acquired abnormalities of insulin action underlie the far more common conditions of type 2 diabetes, obesity and insulin resistance. The latter predisposes to diseases ranging from hypertension to Alzheimer disease and cancer. Hence, understanding the biochemical and cellular properties of insulin receptor signalling is arguably a priority in biomedical research. In the past decade, major progress has led to the delineation of mechanisms of glucose transport, lipid synthesis, storage and mobilization. In addition to direct effects of insulin on signalling kinases and metabolic enzymes, the discovery of mechanisms of insulin-regulated gene transcription has led to a reassessment of the general principles of insulin action. These advances will accelerate the discovery of new treatment modalities for diabetes.

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Insulin primarily induces glucose uptake in fat and muscle, but not liver.
“consistent with insulin primarily inducing glucose uptake in the fat and muscle, but not liver 59”
From Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis (2024) · cites this paper as [59]
The Glucose uptake section says insulin’s effect on glucose uptake is most pronounced in adipocytes and muscle cells. The copy does not establish the categorical ‘but not liver’ distinction: it says insulin stimulates uptake in many cell types and, in the Abstract, promotes glucose utilization in the liver. (LLM, conf=0.83)
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Identification of Novel Candidate Genes for Type 2 Diabetes From a Genome-Wide Association Scan in the Old Order Amish
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Zonation of glucose and fatty acid metabolism in the liver: Mechanism and metabolic consequences
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Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability
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Uncoupling of Acetylation from Phosphorylation Regulates FoxO1 Function Independent of Its Subcellular Localization
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Improved Glucose Homeostasis in Mice with Muscle-Specific Deletion of Protein-Tyrosine Phosphatase 1B
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Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci
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The Phosphotyrosine Interactome of the Insulin Receptor Family and Its Substrates IRS-1 and IRS-2
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Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells
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The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis
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Deletion of Skeletal Muscle SOCS3 Prevents Insulin Resistance in Obesity
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Longitudinal Genome-Wide Association of Cardiovascular Disease Risk Factors in the Bogalusa Heart Study
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Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
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Peripheral Disruption of the Grb10 Gene Enhances Insulin Signaling and Sensitivity In Vivo
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Improved glucose homeostasis and enhanced insulin signalling in Grb14‐deficient mice
Cooney, G. J., Lyons, R. J., Crew, A. J., Jensen, T. E., Molero, J. C., Mitchell, C. J., Biden, T. J., Ormandy, C. J., James, D. E., & Daly, R. J. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600082 · Cited by 136 · see citing works
Mice with a Disruption of the Imprinted <i>Grb10</i> Gene Exhibit Altered Body Composition, Glucose Homeostasis, and Insulin Signaling during Postnatal Life
Smith, F. M., Holt, L. J., Garfield, A. S., Charalambous, M., Koumanov, F., Perry, M., Bazzani, R., Sheardown, S. A., Hegarty, B. D., Lyons, R. J., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02087-06 · Cited by 134 · see citing works
Molecular Cloning of Rat SH2-Containing Inositol Phosphatase 2 (SHIP2) and Its Role in the Regulation of Insulin Signaling
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Turning Off AKT: PHLPP as a Drug Target
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Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.
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Insulin and dietary fructose induce stearoyl-CoA desaturase 1 gene expression of diabetic mice.
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Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway
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Mice Deficient in the Insulin-regulated Membrane Aminopeptidase Show Substantial Decreases in Glucose Transporter GLUT4 Levels but Maintain Normal Glucose Homeostasis
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Absence of functional insulin receptor substrate-3 ( IRS-3 ) gene in humans
rnholm, M. B. X. F., He, A., Attersand, A., Lake, S., Liu, S., Lienhard, G. E., Taylor, S. I., Arner, P., & Zierath, J. R. (2002) · Diabetologia · doi:10.1007/s00125-002-0945-z · Cited by 114 · see citing works
Lipid phosphatases as drug discovery targets for type 2 diabetes
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Structural Basis for Inhibition of the Insulin Receptor by the Adaptor Protein Grb14
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Spatial and Temporal Regulation of Receptor Tyrosine Kinase Activation and Intracellular Signal Transduction.
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Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements
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Demonstration of insulin-responsive trafficking of GLUT4 and vpTR in fibroblasts
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Insulin inhibits transcription of IRS-2 gene in rat liver through an insulin response element (IRE) that resembles IREs of other insulin-repressed genes
Zhang, J., Ou, J., Bashmakov, Y. K., Horton, J. D., Brown, M. S., & Goldstein, J. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071054598 · Cited by 108 · see citing works
Inhibition of Insulin Receptor Catalytic Activity by the Molecular Adapter Grb14
Béréziat, V., Kasus‐Jacobi, A., Perdereau, D., Cariou, B., Girard, J. R., & Burnol, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106574200 · Cited by 102 · see citing works
Pharmacological Inhibition of PI3K Reduces Adiposity and Metabolic Syndrome in Obese Mice and Rhesus Monkeys
Ortega-Molina, A., Lopez-Guadamillas, E., Mattison, J. A., Mitchell, S. J., Muñoz‐Martín, M., Iglesias, G., Gutierrez, V. M., Vaughan, K. L., Szarowicz, M. D., González‐García, I., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.02.017 · Cited by 99 · see citing works
β-TrCP-Mediated Ubiquitination and Degradation of PHLPP1 Are Negatively Regulated by Akt
Li, X., Liu, J., & Gao, T. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00681-09 · Cited by 99 · see citing works
Clk2 and B56β mediate insulin-regulated assembly of the PP2A phosphatase holoenzyme complex on Akt
Rodgers, J. T., Vogel, R. O., & Puigserver, P. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.02.007 · Cited by 99 · see citing works
The Insulin Receptor: A New Target for Cancer Therapy
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Functional Studies of Akt Isoform Specificity in Skeletal Muscle in Vivo; Maintained Insulin Sensitivity Despite Reduced Insulin Receptor Substrate-1 Expression
Cleasby, M. E., Reinten, T. A., Cooney, G. J., James, D. E., & Kraegen, E. W. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0154 · Cited by 98 · see citing works

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“…often causally related to insulin resistance, hypertension, and type 2 diabetes (Taniguchi et al., 2006; Hoehn et al., 2008; Odegaard and Chawla, 2013; Boucher et al., 2014; DeFronzo et al., 2015; Samuel and Shulman, 2016; Haeusler et al., 2018; also see other important highlights in the text box).”
Background
Insulin signaling in health and disease
Saltiel, A. R. (2021) · Journal of Clinical Investigation · doi:10.1172/jci142241 · Cited by 446 · see citing works
Insulin resistance and cardiovascular disease
Kosmas, C. E., Bousvarou, M. D., Kostara, C. E., Papakonstantinou, E. J., Salamou, E., & Guzman, E. (2023) · Journal of International Medical Research · doi:10.1177/03000605231164548 · Cited by 413 · see citing works
MicroRNA-mediated regulation of glucose and lipid metabolism
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Hyperinsulinemia in Obesity, Inflammation, and Cancer
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Therapeutic advances of targeting receptor tyrosine kinases in cancer
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Hepatic Insulin Clearance: Mechanism and Physiology.
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Hyperinsulinaemia in cancer
Gallagher, E. J., & LeRoith, D. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-020-0295-5 · Cited by 241 · see citing works
Insulin: too much of a good thing is bad
Kolb, H., Kempf, K., Röhling, M., & Martin, S. (2020) · BMC Medicine · doi:10.1186/s12916-020-01688-6 · Cited by 242 · see citing works
Cardio-Metabolic Effects of High-Fat Diets and Their Underlying Mechanisms—A Narrative Review
Wali, J. A., Jarzebska, N., Raubenheimer, D., Simpson, S. J., Rodionov, R. N., & O’Sullivan, J. (2020) · Nutrients · doi:10.3390/nu12051505 · Cited by 245 · see citing works
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Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes
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Role of insulin and insulin resistance in androgen excess disorders
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Self-citation
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Adipose Organ Development and Remodeling
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Free radicals and male reproduction.
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Understanding glycaemic control and current approaches for screening antidiabetic natural products from evidence-based medicinal plants
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Mechanisms of Macrophage Polarization in Insulin Signaling and Sensitivity
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Insulin receptor endocytosis in the pathophysiology of insulin resistance
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Insulin Resistance Promotes Parkinson’s Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling
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Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor
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Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis
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PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin
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Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis
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Self-citation
The Relevance of Insulin Action in the Dopaminergic System
Fiory, F., Perruolo, G., Cimmino, I., Cabaro, S., Pignalosa, F. C., Miele, C., Bèguinot, F., Formisano, P., & Oriente, F. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00868 · Cited by 114 · see citing works
Metabolic Changes of Hepatocytes in NAFLD
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The pseudokinase MLKL regulates hepatic insulin sensitivity independently of inflammation
Xu, H., Du, X., Liu, G., Huang, S., Du, W., Zou, S., Tang, D., Fan, C., Xie, Y., Wei, Y., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.02.003 · Cited by 109 · see citing works
Reversing pancreatic β-cell dedifferentiation in the treatment of type 2 diabetes
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Authors: Haeusler, R. A., McGraw, T. E., & Accili, D.
Affiliations: Columbia University (US)
Weill Cornell Medicine (US)
Columbia University Irving Medical Center (US)
Corresponding author: Accili, Domenico
ORCID: Haeusler, Rebecca A.
McGraw, Timothy E.
Accili, Domenico
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2017-10-04
Volume: 19
Issue: 1
Pages: 31-44
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm.2017.89
PMC: PMC5894887
OpenAlex: W2763635492
Cited by: 739
References: 254
Citations by year: 2026: 61 · 2025: 87 · 2024: 99 · 2023: 97 · 2022: 121 · 2021: 108 · 2020: 67 · 2019: 60 · 2018: 34 · 2017: 3 · 2016: 1
FWCI: 4.20
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL125649, P01HL087123)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK057539, R01DK058282, R37DK058282, R01DK052852, T32DK007328, P30DK026687, P30DK063608, P30DK020541, R01DK064819)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: insulin receptor signaling, insulin action, insulin resistance, type 2 diabetes, obesity, glucose transport, lipid metabolism, insulin deficiency, pancreatic beta cells
MeSH terms: Animals, Humans, Insulin, Receptor, Insulin, Transcription, Genetic, Signal Transduction

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Biochemical and cellular properties of insulin receptor signalling

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