The DOI matches its Crossref record.
Viable Molecular Hybrids of Bacteriophage Lambda and Eukaryotic DNA
Open accessAbstract
A bacteriophage λ strain has been constructed and a method developed by which DNA from potentially any source can be covalently inserted through Eco RI cohesive ends into the middle of the λ DNA. These hybrid DNAs can infect nonrestricting Escherichia coli cells and can then propagate as plaque-forming phage. A unique feature of this λ strain is that extra DNA in the middle of its genome is required for plaque formation. A large number of such phages have been produced with E. coli DNA and Drosophila melanogaster DNA.
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Cited by
Phage therapy: From biological mechanisms to future directions
Strathdee, S. A., Hatfull, G. F., Mutalik, V. K., & Schooley, R. T. (2023) · Cell · doi:10.1016/j.cell.2022.11.017 · Cited by 817
Leder, P., Tiemeier, D., & Enquist, L. (1977) · Science · doi:10.1126/science.322278 · Cited by 406
Murray, K., & Murray, N. E. (1975) · Journal of Molecular Biology · doi:10.1016/s0022-2836(75)80086-6 · Cited by 349
Metadata
- Authors
- Thomas, M., Cameron, J. R., & Davis, R. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1974-11
- Volume
- 71
- Issue
- 11
- Pages
- 4579-4583
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1973856483
- Cited by
- 241
- References
- 0
- FWCI
- 55.07
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Viable Molecular Hybrids of Bacteriophage Lambda and Eukaryotic DNA. https://app.cochat.ai/papers/10.1073/pnas.71.11.4579
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- Thomas, M., Cameron, J. R., & Davis, R. W. (1974). Viable Molecular Hybrids of Bacteriophage Lambda and Eukaryotic DNA. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.71.11.4579
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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