Facilitation of Development of Resistance to Morphine Analgesia by Desglycinamide 9 -Lysine Vasopressin
Open accessAbstract
Desglycinamide 9 -lysine vasopressin facilitates development of resistance to the analgesic action of morphine in mice if morphine is administered before the peptide. Desglycinamide 9 -lysine vasopressin is not a morphine antagonist, and does not appear to cause either hyperalgesia or alteration of the response to the technique used for evaluating analgesia.
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Exogenous OT acts in the NAC to reduce formation and expression of tolerance to some behavioral and physiological effects of drugs of abuse.
“This exogenous OT acts in the NAC to reduce both formation and expression of tolerance to some of the behavioral and physiological effects of drugs of abuse (Krivoy et al 1974; Van Ree and De Wied 1977; Kovacs et al 1981; Kovacs and Vanree 1985; Ibragimov et al 1987; Kovacs and Telegdy 1987; Szabo et al 1989; Sarnyai et al 1992).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Krivoy et al 1974
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Self-citation
- Authors
- Krivoy, W. A., Zimmermann, E., & Lande, S.
- Affiliations
- National Institute on Drug Abuse (US)
- University of California, Los Angeles (US)
- Yale University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1974-05
- Volume
- 71
- Issue
- 5
- Pages
- 1852-1856
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC388340
- OpenAlex
- W1966243878
- Cited by
- 96
- References
- 7
- Citations by year
- 2017: 1 · 2013: 1 · 2012: 1
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- morphine analgesia, opioid tolerance, analgesic resistance, vasopressin, opioid antagonism, hyperalgesia, opioid peptides
- MeSH terms
- Amides, Analgesics, Animals, Drug Resistance, Female, Glycine, Lysine, Mice, Inbred Strains, Morphine, Peptides, Reaction Time, Vasopressins, Mice
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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