On the mode of action of an oxytocin derivative (Z-Pro-D-Leu) on morphine-dependence in mice
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OT mitigates withdrawal symptoms of morphine and alcohol and reduces drug-primed reinstatement of responding for amphetamine.
“OT also mitigates the withdrawal symptoms of morphine and alcohol, and reduces drug-primed reinstatement of responding for amphetamine (Kovacs et al 1981; Szabo et al 1988; Carson et al 2010a).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Kovacs et al 1981
Exogenous OT acts in the NAC to reduce formation and expression of tolerance to some behavioral and physiological effects of drugs of abuse.
“This exogenous OT acts in the NAC to reduce both formation and expression of tolerance to some of the behavioral and physiological effects of drugs of abuse (Krivoy et al 1974; Van Ree and De Wied 1977; Kovacs et al 1981; Kovacs and Vanree 1985; Ibragimov et al 1987; Kovacs and Telegdy 1987; Szabo et al 1989; Sarnyai et al 1992).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Kovacs et al 1981
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Burkett, J. P., & Young, L. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2794-x · Cited by 307 · see citing works
“OT also mitigates the withdrawal symptoms of morphine and alcohol and reduces drugprimed reinstatement of responding for amphetamine (Kovacs et al. 1981; Szabo et al. 1988; Carson et al. 2010a; for a review of this literature, see Kovacs et al. 1998; McGregor and Bowen 2012).”
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Self-citationRomantic Love vs. Drug Addiction May Inspire a New Treatment for Addiction
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Self-citationEffects of brain natriuretic peptide on effects of morphine in mice
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Self-citationC-type natriuretic peptide can modify the acute and chronic effects of morphine
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Self-citationInfluence of dipeptides on precipitated morphine withdrawal in the mouse
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Self-citationd-pipecolic acid inhibits ethanol tolerance in mice
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Self-citationN-Z-Pro– D -Leu using synchrotron radiation data from a very small crystal
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Neurohypophyseal Hormones and Drugs of Misuse
Johnson, J. L., Johnson, M., & Buisman‐Pijlman, F. T. A. (2017) · Royal Society of Chemistry eBooks · doi:10.1039/9781782621577-00346
- Authors
- Kovács, G. L., Szontágh, L., Baláspiri, L., Hódi, K., Bohus, P., & Telegdy, G.
- Affiliations
- University of Szeged (HU)
- ORCID
- Kovács, G.L.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 1981-07
- Volume
- 20
- Issue
- 7
- Pages
- 647-651
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W1969763840
- Cited by
- 28
- References
- 24
- Citations by year
- 2017: 2 · 2016: 1 · 2015: 1 · 2012: 1
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- morphine dependence, physical dependence, naloxone challenge, antinociception, norepinephrine, dopamine, serotonin, monoaminergic neurotransmission, brainstem, central nervous system, opioid tolerance
- MeSH terms
- Animals, Biogenic Amines, Brain Chemistry, Dipeptides, Humans, Injections, Intraventricular, Male, Morphine Dependence, Naloxone, Pain, Substance Withdrawal Syndrome, Mice
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