The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Chemical induction of sperm abnormalities in mice.
Open accessAbstract
The sperm of (C57BL X C3H)F1 mice were examined 1, 4, and 10 weeks after a subacute treatment with one of 25 chemicals at two or more dose levels. The fraction of sperm that were abnormal in shape was elevated above control values of 1.2-3.4% for methyl methanesulfonate, ethyl methanesulfonate, griseofulvin, benzo[a]pyrene, METEPA [tris(2-methyl-l-aziridinyl)phosphine oxide], THIO-TEPA [tris(l-aziridinyl)phosphine sulfide], mitomycin C, myleran, vinblastine sulphate, hydroxyurea, 3-methylcholanthrene, colchicine, actinomycin D, imuran, cyclophosphamide, 5-iododeoxyuridine, dichlorvos, aminopterin, and trimethylphosphate. Dimethylnitrosamine, urethane, DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane], 1,1-dimethylhydrazine, caffeine, and calcium cyclamate did not induce elevated levels of sperm abnormalities. The results suggest that sperm abnormalities might provide a rapid inexpensive mammalian screen for agents that lead to errors in the differentiation of spermatogenic stem cells in vivo and thus indicate agents which might prove to be mutagenic, teratogenic, or carcinogenic.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Detection of chemical mutagens by the dominant lethal assay in the mouse
Epstein, S. S., Arnold, E., Andrea, J., Bass, W., & Bishop, Y. (1972) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(72)90192-5 · Cited by 564
Morphogenetic factors influencing the shape of the sperm head
Fawcett, D. W., Anderson, W. A., & Phillips, D. M. (1971) · Developmental Biology · doi:10.1016/0012-1606(71)90124-2 · Cited by 455
SWANN, P. F., & MAGEE, P. N. (1968) · Biochemical Journal · doi:10.1042/bj1100039 · Cited by 371
CHEMICAL MUTAGENS: PRINCIPLES AND METHODS FOR THEIR DETECTION
(1972) · Medical Journal of Australia · doi:10.5694/j.1326-5377.1972.tb46919.x · Cited by 265
TRISOMY AFTER COLCHICINE THERAPY
Ferreira, N. R., & Buoniconti, A. (1968) · The Lancet · doi:10.1016/s0140-6736(68)91805-9 · Cited by 171
Report of the Secretary's Commission on Pesticides and Their Relationship to Environmental Health
(1971) · Food and Cosmetics Toxicology · doi:10.1016/0015-6264(71)90047-2 · Cited by 109
EFFECT ON THE OFFSPRING OF REPEATED CAFFEINE ADMINISTRATION TO PREGNANT RATS
Gilbert, E. F., & Pistey, W. R. (1973) · Reproduction · doi:10.1530/jrf.0.0340495 · Cited by 73
On the mutagenic action of dichlorvos
Voogd, C. E., Jacobs, J., & Jj, V. D. S. (1972) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/0027-5107(72)90210-2 · Cited by 62
Caffeine as teratogen and mutagen
Mulvihill, J. J. (1973) · Teratology · doi:10.1002/tera.1420080109 · Cited by 44
A collaborative study of in vivo cytogenetic analysis
Legator, M. S., Palmer, K. A., & Adler, I. ‐. (1973) · Toxicology and Applied Pharmacology · doi:10.1016/0041-008x(73)90040-9 · Cited by 43
Cited by
Identifying Environmental Chemicals Causing Mutations and Cancer
Ames, B. N. (1979) · Science · doi:10.1126/science.373122 · Cited by 586
Cyclophosphamide: Review of its mutagenicity for an assessment of potential germ cell risks
Anderson, D., Bishop, J. B., Garner, R. C., Ostrosky-Wegman, P., & Selby, P. B. (1995) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/0027-5107(95)00039-l · Cited by 301
D'Souza, S. P., Vijayalaxmi, K. K., & Naik, P. (2014) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2014.02.006 · Cited by 30
Metadata
- Authors
- Wyrobek, A. J., & Bruce, W. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1975-11
- Volume
- 72
- Issue
- 11
- Pages
- 4425-4429
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1973337372
- Cited by
- 874
- References
- 14
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Chemical induction of sperm abnormalities in mice. https://app.cochat.ai/papers/10.1073/pnas.72.11.4425
- The paper
- Wyrobek, A. J., & Bruce, W. R. (1975). Chemical induction of sperm abnormalities in mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.72.11.4425
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
