Assessment of genotoxicity of aluminium acetate in bone marrow, male germ cells and fetal liver cells of Swiss albino mice
Abstract
Aluminium acetate (AA) has many pharmaceutical applications, which necessitates a thorough evaluation of its toxicity. Dose- and time-dependent genotoxic effects of AA were investigated in Swiss albino mice after exposure via intraperitoneal (i.p.) injection, by employing assays to detect chromosomal aberrations (CA) and micronuclei (MN) in bone marrow, MN in fetal liver, and abnormalities in sperm. Animals were treated with single doses of 50, 100 and 150mg/kg body weight (bw), and with daily doses of 50mg/kg bw for seven consecutive days, in order to study the effects of acute and cumulative doses, respectively. Post-treatment sampling was done at 24, 48 and 72h for bone-marrow CA and MN tests, to study time-dependent effects. Both single and repeated exposures of AA induced chromosomal aberrations, which were dose and time-dependent. The MN test failed to demonstrate genotoxicity after the single-dose exposures, indicating that a higher threshold dose is required for MN induction. Repeated treatment of AA, however, induced MN formation even at the low dose (P<0.05), reflecting genotoxicity following chronic/sub-chronic exposure. A significant reduction in mitotic index and in the P/N (polychromatic/normochromatic erythrocytes) ratio suggests that AA also has a mitodepressive effect in bone-marrow cells. AA-induced germinal genotoxicity was evident from a significant and dose-dependent increase in the percentage of abnormal spermatozoa and a reduction in sperm count. Transp…
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Exposure to Al during mouse pregnancy resulted in reduced fetal weight and increased frequency of external anomalies in fetuses and fetal micronucleated erythrocytes.
“Exposure to Al during mouse pregnancy resulted in reduced fetal weight and increased frequency of external anomalies in fetuses (Malekshah et al., 2005) and fetal micronucleated erythrocytes (D’Souza et al., 2014).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as D’Souza et al., 2014
Genotoxicity from Al exposure in mice resulted in a mitodepressive effect in the bone marrow.
“The genotoxicity from Al exposure in mice resulted in mitodepressive effect in the bone marrow (D’Souza et al., 2014).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as D’Souza et al., 2014
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- Authors
- D'Souza, S. P., Vijayalaxmi, K. K., & Naik, P.
- Affiliations
- Mangalore University (IN)
- Corresponding author
- Vijayalaxmi, K.K.
- ORCID
- Naik, Prashantha
- Venue
- Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 766
- Pages
- 16-22
- ISSN
- 1383-5718 (ISSN-L)
- OpenAlex
- W2007206964
- Semantic Scholar
- 1dfc64891e6aaf5c1e19c0bb443d62d8d0c6b5a8
- Cited by
- 30
- References
- 82
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mutation Research/Genetic Toxicology and Environmental Mutagenesis (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Food Safety Authority
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- genotoxicity, chromosomal abnormalities, micronuclei, bone marrow, male germ cells, sperm abnormalities, fetal liver, transplacental exposure, dose-dependent effects, Swiss mice
- MeSH terms
- Acetates, Animals, Bone Marrow Cells, Chromosome Aberrations, DNA Damage, Female, Fetus, Liver, Male, Sperm Count, Spermatozoa, Time Factors, Micronuclei, Chromosome-Defective, Mice
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