Cited by 30Carcinogens and Genotoxicity AssessmentAluminum toxicity and tolerance in plants and animalsImmunotoxicology and immune responses

Assessment of genotoxicity of aluminium acetate in bone marrow, male germ cells and fetal liver cells of Swiss albino mice

D'Souza, Sr. Prem, Vijayalaxmi, K.K., Naik, Prashantha·2014·Mutation Research/Genetic Toxicology and Environmental Mutagenesis

Abstract

Aluminium acetate (AA) has many pharmaceutical applications, which necessitates a thorough evaluation of its toxicity. Dose- and time-dependent genotoxic effects of AA were investigated in Swiss albino mice after exposure via intraperitoneal (i.p.) injection, by employing assays to detect chromosomal aberrations (CA) and micronuclei (MN) in bone marrow, MN in fetal liver, and abnormalities in sperm. Animals were treated with single doses of 50, 100 and 150mg/kg body weight (bw), and with daily doses of 50mg/kg bw for seven consecutive days, in order to study the effects of acute and cumulative doses, respectively. Post-treatment sampling was done at 24, 48 and 72h for bone-marrow CA and MN tests, to study time-dependent effects. Both single and repeated exposures of AA induced chromosomal aberrations, which were dose and time-dependent. The MN test failed to demonstrate genotoxicity after the single-dose exposures, indicating that a higher threshold dose is required for MN induction. Repeated treatment of AA, however, induced MN formation even at the low dose (P<0.05), reflecting genotoxicity following chronic/sub-chronic exposure. A significant reduction in mitotic index and in the P/N (polychromatic/normochromatic erythrocytes) ratio suggests that AA also has a mitodepressive effect in bone-marrow cells. AA-induced germinal genotoxicity was evident from a significant and dose-dependent increase in the percentage of abnormal spermatozoa and a reduction in sperm count. Transp…

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Crossref · 10.1016/j.mrgentox.2014.02.006

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  • Exposure to Al during mouse pregnancy resulted in reduced fetal weight and increased frequency of external anomalies in fetuses and fetal micronucleated erythrocytes.

    “Exposure to Al during mouse pregnancy resulted in reduced fetal weight and increased frequency of external anomalies in fetuses (Malekshah et al., 2005) and fetal micronucleated erythrocytes (D’Souza et al., 2014).”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as D’Souza et al., 2014

  • Genotoxicity from Al exposure in mice resulted in a mitodepressive effect in the bone marrow.

    “The genotoxicity from Al exposure in mice resulted in mitodepressive effect in the bone marrow (D’Souza et al., 2014).”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as D’Souza et al., 2014

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6 of the 82 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

  1. Savage, 1975, Classification and relationships of induced structural changes, J. Med. Genet., 12, 103
  2. Manna, 1972, Chromosome aberrations in mice induced by aluminium chloride, Nucleus, 15, 180
  3. Sushma, 2009, Lipid peroxidation and some oxidative stress enzymes in aluminium acetate intoxicated albino mice, Toxicol. Int., 16, 1
  4. Buraimoh, 2012, Effects of aluminium chloride exposure on the sperm count of adult male Wistar rats, Asian J. Exp. Biol. Sci., 3, 439

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Authors
D'Souza, S. P., Vijayalaxmi, K. K., & Naik, P.
Affiliations
Mangalore University (IN)
Corresponding author
Vijayalaxmi, K.K.
Venue
Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Publisher
Elsevier BV
Published
2014-05
Volume
766
Pages
16-22
ISSN
1383-5718 (ISSN-L)
OpenAlex
W2007206964
Cited by
30
References
82
Citations by year
2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 1
FWCI
0.96
Type
journal article
Language
en
Open access
closed
Locations
  • Mutation Research/Genetic Toxicology and Environmental Mutagenesis (publishedVersion)
  • PubMed (publishedVersion)
Funders
European Food Safety Authority
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords
genotoxicity, chromosomal abnormalities, micronuclei, bone marrow, male germ cells, sperm abnormalities, fetal liver, transplacental exposure, dose-dependent effects, Swiss mice
MeSH terms
Acetates, Animals, Bone Marrow Cells, Chromosome Aberrations, DNA Damage, Female, Fetus, Liver, Male, Sperm Count, Spermatozoa, Time Factors, Micronuclei, Chromosome-Defective, Mice

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