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Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro.
Open accessAbstract
The differentiation in vitro of clonal pluripotent teratocarcinoma cells is reported. The first stage of this process is the formation of simple embryoid bodies which are identical to those found in animals bearing intraperitoneal teratocarcinomas. They consist of an inner core of embryonal carcinoma cells surrounded by a layer of endodermal cells which produce Reichert's membrane. The endodermal cells become apparent shortly after the embryonal carcinoma cells have formed aggregates which are loosely attached to the substratum. One clonal teratocarcinoma line was found to produce complex cystic embryoid bodies in vitro. Following formation of the endodermal cells, extensive differentiation to a wide variety of cell types occurs. There are similarities between the process of embryoid body formation and the early events of differentiation of the mouse embryo.
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Cited by
Kanellopoulou, C., Muljo, S. A., Kung, A. L., Ganesan, S., Drapkin, R., Jenuwein, T., Livingston, D. M., & Rajewsky, K. (2005) · Genes & Development · doi:10.1101/gad.1248505 · Cited by 1,254
Visualizing structure and transitions in high-dimensional biological data
Moon, K. R., van Dijk, D., Wang, Z., Gigante, S., Burkhardt, D. B., Chen, W. S., Yim, K., Elzen, A. V. D., Hirn, M. J., Coifman, R. R., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0336-3 · Cited by 1,065
Retinoic acid induces embryonal carcinoma cells to differentiate into neurons and glial cells.
Jones-Villeneuve, E. M., McBurney, M. W., Rogers, K. A., & Kalnins, V. I. (1982) · The Journal of cell biology · doi:10.1083/jcb.94.2.253 · Cited by 781
Dynamic stem cell states: Naive to primed pluripotency in rodents and humans
Weinberger, L., Ayyash, M., Novershtern, N., & Hanna, J. H. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2015.28 · Cited by 622
Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst
Plusa, B., Piliszek, A., Frankenberg, S., Artus, J., & Hadjantonakis, A.-K. (2008) · Development · doi:10.1242/dev.021519 · Cited by 556
Metadata
- Authors
- Martin, G. R., & Evans, M. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1975-04
- Volume
- 72
- Issue
- 4
- Pages
- 1441-1445
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2012100973
- Cited by
- 718
- References
- 0
- FWCI
- 7.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Martin, G. R., & Evans, M. J. (1975). Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.72.4.1441
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