The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.
Open accessAbstract
Narcotics affect adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] in two opposing ways, both mediated by the opiate receptor. The first process is the readily reversible inhibition of the enzyme by narcotics; the second is a compensatory increase in enzyme activity which is delayed in onset and relatively stable. Late positive regulation of the enzyme counteracts the inhibitory influence of morphine and is responsible for narcotic dependence and tolerance. The coupled inhibitory and positive regulatory mechanisms for adenylate cyclase provide a means of activating and deactivating neural circuits hours after the initial event and thus may play a role in a memory process.
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
Lowry, O., Rosebrough, N., Farr, A. L., & Randall, R. (1951) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52451-6 · Cited by 317,331
A Protein Binding Assay for Adenosine 3′:5′-Cyclic Monophosphate
Gilman, A. G. (1970) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.67.1.305 · Cited by 3,249
Hughes, J. (1975) · Brain Research · doi:10.1016/0006-8993(75)90391-1 · Cited by 982
Morphine receptors as regulators of adenylate cyclase activity.
Sharma, S. K., Nirenberg, M., & Klee, W. A. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.2.590 · Cited by 531
Self-citationCollier, H. O. J., & Roy, A. C. (1974) · Nature · doi:10.1038/248024a0 · Cited by 374
A Neuroblastoma × Glioma Hybrid Cell Line with Morphine Receptors
Klee, W. A., & Nirenberg, M. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.9.3474 · Cited by 315
Self-citationNarcotic Receptor Sites in Morphine-dependent Rats
KLEE, W. A., & STREATY, R. A. (1974) · Nature · doi:10.1038/248061a0 · Cited by 201
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Cited by
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647
Molecular and Cellular Basis of Addiction
Nestler, E. J., & Aghajanian, G. K. (1997) · Science · doi:10.1126/science.278.5335.58 · Cited by 1,313
Molecular mechanisms of drug addiction
Nestler, E. J. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.031 · Cited by 1,108
Cellular and Synaptic Adaptations Mediating Opioid Dependence
Williams, J. T., Christie, M. J., & Manzoni, O. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.1.299 · Cited by 848
Historical review: molecular and cellular mechanisms of opiate and cocaine addiction
Nestler, E. J. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.02.005 · Cited by 425
Metadata
- Authors
- Sharma, S. K., Klee, W. A., & Nirenberg, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1975-08
- Volume
- 72
- Issue
- 8
- Pages
- 3092-3096
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2084043489
- Cited by
- 665
- References
- 7
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Sharma, S. K., Klee, W. A., & Nirenberg, M. (1975). Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.72.8.3092
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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