The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Molecular and Cellular Basis of Addiction
Abstract
Drug addiction results from adaptations in specific brain neurons caused by repeated exposure to a drug of abuse. These adaptations combine to produce the complex behaviors that define an addicted state. Progress is being made in identifying such time-dependent, drug-induced adaptations and relating them to specific behavioral features of addiction. Current research needs to understand the types of adaptations that underlie the particularly long-lived aspects of addiction, such as drug craving and relapse, and to identify specific genes that contribute to individual differences in vulnerability to addiction. Understanding the molecular and cellular basis of addictive states will lead to major changes in how addiction is viewed and ultimately treated.
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Citations
Cites
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Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
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Control of memory formation through regulated expression of a CaMKII transgene
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Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain
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Molecular mechanisms of drug addiction
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Self-citationWise, R. A. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80079-1 · Cited by 1,072
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Self-citation
Cited by
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Kalivas, P. W., & Volkow, N. D. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1403 · Cited by 2,757
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647
Self-citationDrug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535
Depue, R. A., & Collins, P. F. (1999) · Behavioral and Brain Sciences · doi:10.1017/s0140525x99002046 · Cited by 2,046
Metadata
- Authors
- Nestler, E. J., & Aghajanian, G. K.
- Venue
- Science
- Published
- 1997-10-03
- Volume
- 278
- Issue
- 5335
- Pages
- 58-63
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981891173
- Cited by
- 1,313
- References
- 107
- FWCI
- 26.72
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
