Cited by 2,296Plant Virus Research StudiesPlant and Fungal Interactions ResearchPlant Molecular Biology Research

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures

Open access

Sanger, H L, Klotz, G, Riesner, D, Gross, H J, Kleinschmidt, A K·1976·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.73.11.3852PMC PMC431239

Open this paper in CoChat — free account

Abstract

Viroids are uncoated infectious RNA molecules pathogenic to certain higher plants. Four different highly purified viroids were studied. By ultracentrifugation, thermal denaturation, electron microscopy, and end group analysis the following features were established: (i) the molecular weight of cucumber pale fruit viroid from tomato is 110,000, of citrus exocortis viroid from Gynura 119,000, of citrus exocortis viroid from tomato 119,000 and of potato spindle tuber viroid from tomato 127,000. (ii) Viroids are single-stranded molecules. (iii) Virods exhibit high thermal stability, cooperativity, and self-complementarity resulting in a rod-like native structure. (iv) Viroids are covalently closed circular RNA molecules.

Integrity signals

Registry

Crossref · 10.1073/pnas.73.11.3852

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A simple method for the preparation of 32P-labelled adenosine triphosphate of high specific activity
Glynn, I. M., & Chappell, J. W. (1964) · Biochemical Journal · doi:10.1042/bj0900147 · Cited by 1,880
Potato spindle tuber “virus”
Diener, T. O. (1971) · Virology · doi:10.1016/0042-6822(71)90342-4 · Cited by 496
Analytical studies on nuclear ribonucleic acid using polyacrylamide gel electrophoresis
Dingman, C. W., & Peacock, A. C. (1968) · Biochemistry · doi:10.1021/bi00842a022 · Cited by 279
Circular DNA
Helinski, D. R., & Clewell, D. B. (1971) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.40.070171.004343 · Cited by 178
A routine method for protein-free spreading of double- and single-stranded nucleic acid molecules.
Vollenweider, H. J., Sogo, J. M., & Koller, T. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.1.83 · Cited by 169
Exocortis virus: An infectious free-nucleic acid plant virus with unusual properties
Semancik, J. S., & Weathers, L. G. (1972) · Virology · doi:10.1016/0042-6822(72)90281-4 · Cited by 150
Exocortis Disease: Evidence for a New Species of “Infectious” Low Molecular Weight RNA in Plants
Semancik, J. S., & Weathers, L. G. (1972) · Nature New Biology · doi:10.1038/newbio237242a0 · Cited by 148
Physical properties of a minimal infectious RNA (viroid) associated with the exocortis disease
Semancik, J. S., Morris, T. J., Weathers, L. G., Rordorf, B. F., & Kearns, D. R. (1975) · Virology · doi:10.1016/0042-6822(75)90381-5 · Cited by 140
Handbook of nucleic acid sequences
BARRELL, B. G., & Clark, B. F. C. (1974) · Medical Entomology and Zoology · Cited by 137
Potato spindle tuber viroid
Sogo, J. M., Koller, T., & Diener, T. O. (1973) · Virology · doi:10.1016/s0042-6822(73)81009-8 · Cited by 129

Show all 27 references

Sorted by citations

Items 701–800 of 1,000

Bioinformatic Analysis of Circular RNA-Associated ceRNA Network Associated with Hepatocellular Carcinoma
Wu, J., Liu, S., Xiang, Y., Qu, X., Xie, Y., & Zhang, X. (2019) · BioMed Research International · doi:10.1155/2019/8308694 · Cited by 33
Screening for differentially expressed circRNA between Kashin–Beck disease and osteoarthritis patients based on circRNA chips
Wang, Y., Wu, C., Zhang, Y., Yang, Y., Ren, Z., Lammi, M. J., & Guo, X. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.10.026 · Cited by 34
hsa_circRNA_012515 Is Highly Expressed in NSCLC Patients and Affects Its Prognosis
Fu, Y., Huang, L., Tang, H. T., & Huang, R. (2020) · Cancer Management and Research · doi:10.2147/cmar.s245525 · Cited by 33
Predicting novel CircRNA-disease associations based on random walk and logistic regression model
Ding, Y., Chen, B., Lei, X., Liao, B., & Wu, F. (2020) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2020.107287 · Cited by 34
Distinct 5-methylcytosine profiles of circular RNA in human hepatocellular carcinoma.
He, Y., Zhang, Q., Zheng, Q., Yu, X., & Guo, W. (2020) · PubMed Central · Cited by 33
Circ11103 Interacts with miR-128/PPARGC1A to Regulate Milk Fat Metabolism in Dairy Cows
Chen, Z., Lu, Q., Liang, Y., Cui, X., Wang, X., Mao, Y., & Yang, Z. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c07018 · Cited by 33
circPTPN22 as a novel biomarker and ceRNA in peripheral blood mononuclear cells of rheumatoid arthritis
Jiang, Z., Zhong, Z., Miao, Q., Zhang, Y., Ni, B., Zhang, M., & Tang, J. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12256 · Cited by 33
Non-Coding RNAs in Pancreatic Cancer Diagnostics and Therapy: Focus on lncRNAs, circRNAs, and piRNAs
Li, Y., Hallak, M. N. A., Philip, P. A., Azmi, A. S., & Mohammad, R. M. (2021) · Cancers · doi:10.3390/cancers13164161 · Cited by 34
The Value of Circulating Circular RNA in Cancer Diagnosis, Monitoring, Prognosis, and Guiding Treatment
Zhang, Y., Wang, Y., Su, X., Wang, P., & Lin, W. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.736546 · Cited by 37
Pseudogenes: A Novel Source of trans-Acting Antisense RNAs
Johnsson, P., Morris, K. V., & Grandér, D. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0835-6_14 · Cited by 33
In Vitro synthesis of an infectious viroid: Analysis of the infectivity of monomeric linear CEV
Rigden, J. E., & Rezaian, M. A. (1992) · Virology · doi:10.1016/0042-6822(92)90074-y · Cited by 33
Viroids
Diener, T. O. (1983) · Advances in virus research · doi:10.1016/s0065-3527(08)60725-3 · Cited by 33
Potato spindle tuber and citrus exocortis viroids undergo no major sequence changes during replication in two different hosts
Dickson, E., Diener, T. O., & Robertson, H. D. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.2.951 · Cited by 33
The comprehensive expression analysis of circular RNAs in gastric cancer and its association with field cancerization
Vidal, A. F., Ribeiro-dos-Santos, A. M., Vinasco‐Sandoval, T., de Magalhães, L. L., Pinto, P., Anaissi, A. K. M., Demachki, S., de Assumpção, P. P., dos Santos, S. E. B., & Ribeiro‐dos‐Santos, Â. (2017) · Scientific Reports · doi:10.1038/s41598-017-15061-w · Cited by 32
Circular RNAs as Novel Biomarkers for Cardiovascular Diseases
Zhou, Q., Zhang, Z., Bei, Y., Li, G., & Wang, T. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1426-1_13 · Cited by 32
Microarray expression profile of circular RNAs and mRNAs in children with systemic lupus erythematosus
Li, S., Zhang, J., Tan, X., Deng, J., Li, Y., Piao, Y., Li, C., Yang, W., Mo, W., Sun, F., et al. (2019) · Clinical Rheumatology · doi:10.1007/s10067-018-4392-8 · Cited by 32
Silencing circular RNA hsa_circ_0004491 promotes metastasis of oral squamous cell carcinoma
Li, X., Zhang, H., Wang, Y., Sun, S., Shen, Y., & Yang, H. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116883 · Cited by 32
CircMMP11 acts as a ce-circRNA in breast cancer progression by regulating miR-1204.
Li, Z., Chen, Z., Feng, Y., Hu, G., & Jiang, Y. (2020) · PubMed Central · Cited by 32
Identification and Characterization of circRNA in Longissimus Dorsi of Different Breeds of Cattle
Liu, R., Liu, X., Bai, X., Xiao, C., & Dong, Y. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.565085 · Cited by 30
Exosomal circRNAs: Sorting Mechanisms, Roles and Clinical Applications in Tumors
Xu, Y., Kong, S., Qin, S., Shen, X., & Ju, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.581558 · Cited by 33
The Roles of CircRNAs in Regulating Muscle Development of Livestock Animals
Yang, Z., He, T., & Chen, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.619329 · Cited by 33
CircRNAs: Decrypting the novel targets of fibrosis and aging
Yang, Y., Lei, W., Jiang, S., Ding, B., Wang, C., Chen, Y., Shi, W., Wu, Z., & Tian, Y. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101390 · Cited by 32
CircRNAs as potent biomarkers in ovarian cancer: a systematic scoping review
Foruzandeh, Z., Sehrig, F. Z., Nejati‐Koshki, K., Rahmanpour, D., Pashazadeh, F., Seif, F., & Alivand, M. R. (2021) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-021-00284-7 · Cited by 32
Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer
Wang, S., Chao, F., Zhang, C., Han, D., Xu, G., & Chen, G. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.10.021 · Cited by 32
The role and mechanism of noncoding RNAs in regulation of metabolic reprogramming in hepatocellular carcinoma
Liao, W., Du, J., Wang, Z., Feng, Q., Liao, M., Liu, H., Yuan, K., & Zeng, Y. (2022) · International Journal of Cancer · doi:10.1002/ijc.34040 · Cited by 31
Promising Strategies for Preserving Adult Endothelium Health and Reversing Its Dysfunction: From Liquid Biopsy to New Omics Technologies and Noninvasive Circulating Biomarkers
Balistreri, C. R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147548 · Cited by 33
mRNA COVID-19 Vaccines—Facts and Hypotheses on Fragmentation and Encapsulation
Jacques Demongeot, A., & Fougère, C. (2022) · Vaccines · doi:10.3390/vaccines11010040 · Cited by 36
Structure and function of viroids
Riesner, D., Steger, G., Schumacher, J., Gross, H. J., Randles, J. W., & S�nger, H. L. (1983) · European Biophysics Journal · doi:10.1007/bf00537813 · Cited by 31
Self-citation
Computational approaches and challenges in the analysis of circRNA data
Digby, B., Finn, S. P., & Broin, P. Ó. (2024) · BMC Genomics · doi:10.1186/s12864-024-10420-0 · Cited by 32
Identification of circular RNA signature in bladder cancer
Yang, X. F., Yuan, W., Tao, J., Li, P., Yang, C., Deng, X., Zhang, X., Tang, J., Han, J., Wang, J., et al. (2017) · Journal of Cancer · doi:10.7150/jca.19345 · Cited by 31
Differential Expression of Circular RNAs in Polytocous and Monotocous Uterus during the Reproductive Cycle of Sheep
La, Y., Tang, J., Di, R., Wang, X., Liu, Q., Zhang, L., Zhang, X., Zhang, J., Hu, W., & Chu, M. (2019) · Animals · doi:10.3390/ani9100797 · Cited by 31
Identification of Circular RNAs using RNA Sequencing
Sekar, S., Geiger, P. A., Cuyugan, L., Boyle, A., Serrano, G. E., Beach, T. G., & Liang, W. S. (2019) · Journal of Visualized Experiments · doi:10.3791/59981 · Cited by 34
The emerging role of circular RNAs in gastric cancer.
Shi, P., Wan, J., Song, H., & Ding, X. (2018) · Europe PMC (PubMed Central) · Cited by 28
The progress of circular RNAs in various tumors.
Wang, D., Yang, S., Wang, H., Wang, J., Zhang, Q., Zhou, S., He, Y., Zhang, H., Deng, F., Xu, H., et al. (2018) · Europe PMC (PubMed Central) · Cited by 31
The Role of Circular RNAs in Pancreatic Ductal Adenocarcinoma and Biliary-Tract Cancers
Limb, C., Liu, D., Venø, M. T., Rees, E., Krell, J., Bagwan, I., Giovannetti, E., Pandha, H., Strobel, O., Rockall, T., et al. (2020) · Cancers · doi:10.3390/cancers12113250 · Cited by 31
CircRNAs open a new era in the study of cardiovascular disease (Review)
Yu, Z., Huang, Q., Zhang, Q., Wu, H., & Zhong, Z. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4792 · Cited by 35
Circular RNAs in the Central Nervous System
Li, M., Wang, W., & Jin, Z. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.629593 · Cited by 31
Circular RNAs: new biomarkers of chemoresistance in cancer
Wang, J., Zhang, Y., Liu, L., Yang, T., & Song, J. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2020.0312 · Cited by 31
The Role of N6-Methyladenosine Modified Circular RNA in Pathophysiological Processes
Tang, M., & Lv, Y. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.60131 · Cited by 32
The Function and Therapeutic Potential of Circular RNA in Cardiovascular Diseases
Wang, K., Gao, X., Wang, T., & Zhou, L. (2021) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-021-07228-5 · Cited by 31
Progress in 50 years of viroid research—Molecular structure, pathogenicity, and host adaptation
Sano, T. (2021) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.97.020 · Cited by 31
Serum Exosomal Circular RNA Expression Profile and Regulative Role in Proliferative Diabetic Retinopathy
Li, X., Wang, J., Qian, H., Wu, Y. H., Zhang, Z., Hu, Z., & Xie, P. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.719312 · Cited by 31
The circular RNA circBCL2L1 regulates innate immune responses via microRNA-mediated downregulation of TRAF6 in teleost fish
Zheng, W., Sun, L., Yang, L., & Xu, T. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101199 · Cited by 31
Emerging functions of circular RNA in the regulation of adipocyte metabolism and obesity
Zhang, Y., Tian, Z., Ye, H., Sun, X., Zhang, H., Sun, Y., Mao, Y., Yang, Z., & Li, M. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01062-w · Cited by 33
SGCNCMI: A New Model Combining Multi-Modal Information to Predict circRNA-Related miRNAs, Diseases and Genes
Yu, C.-Q., Wang, X., Li, L., You, Z., Huang, W., Li, Y.-C., Ren, Z.-H., & Guan, Y.-J. (2022) · Biology · doi:10.3390/biology11091350 · Cited by 31
Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis
Zhang, C., Wei, G., Zhu, X., Chen, X., Ma, X., Hu, P., Liu, W., Yang, W., Ruan, T., Zhang, W., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s391872 · Cited by 33
The Landscape of Circular RNAs in Cardiovascular Diseases
Long, Q., Lv, B., Jiang, S., & Lin, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054571 · Cited by 32
circRNA-miRNA-mRNA Deregulated Network in Ischemic Heart Failure Patients
Madè, A., Bibi, A., García-Manteiga, J. M., Tascini, A. S., Piella, S. N., Tikhomirov, R., Voellenkle, C., Gaetano, C., Leszek, P., Castelvecchio, S., et al. (2023) · Cells · doi:10.3390/cells12212578 · Cited by 32
CircRNA and ferroptosis in human disease: Insights for new treatments
Liu, R., Zhou, Y., & Cao, Y. (2023) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12365 · Cited by 33
Circular RNAs as Novel Biomarkers with Regulatory Potency in Human Diseases
Fang, Y. (2018) · Future Science OA · doi:10.4155/fsoa-2018-0036 · Cited by 30
Circular RNAs in leukemia
Wu, Z., Sun, H., Li, J., & Jin, H. Z. (2019) · Aging · doi:10.18632/aging.102091 · Cited by 31
Predicting circRNA–Disease Associations Based on Improved Collaboration Filtering Recommendation System With Multiple Data
Lei, X., Fang, Z., & Guo, L. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00897 · Cited by 31
RNA-Seq profiling of circular RNAs and potential function of hsa_circ_0002360 in human lung adenocarcinom.
Yan, Y., Zhang, R., Zhang, X., Zhang, A., Zhang, Y., & Bu, X. (2019) · Europe PMC (PubMed Central) · Cited by 30
Circular RNA Expression Profiles in Nasopharyngeal Carcinoma by Sequence Analysis
Yang, J., Gong, Y., Jiang, Q., Liu, L., Li, S., Zhou, Q., Huang, F., & Liu, Z. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00601 · Cited by 30
Non-coding RNAs in drug resistance of head and neck cancers: A review
Dai, F., Dai, L., Zheng, X., Guo, Y., Zhang, Y., Niu, M., Lü, Y., Li, H., Hou, R., Zhang, Y., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110231 · Cited by 30
Circular RNAs: Novel biomarkers for cervical, ovarian and endometrial cancer (Review)
Shi, Y., He, R., Yu, Y., He, Y., Shao, K., Zhan, L., & Wei, B. (2020) · Oncology Reports · doi:10.3892/or.2020.7780 · Cited by 30
The Potential of Circular RNAs as Cancer Biomarkers
Brown, J. R., & Chinnaiyan, A. M. (2020) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-20-0796 · Cited by 32
Epigenetic Regulation of Pulmonary Arterial Hypertension-Induced Vascular and Right Ventricular Remodeling: New Opportunities?
Kocken, J. M. M., & Martins, P. A. D. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238901 · Cited by 30
Underlying metastasis mechanism and clinical application of exosomal circular RNA in tumors (Review)
Wei, X., Shi, Y., Dai, Z., Wang, P., Meng, X., & Yin, B. (2021) · International Journal of Oncology · doi:10.3892/ijo.2021.5179 · Cited by 30
Methods to study circRNA-protein interactions
Ulshöfer, C. J., Pfafenrot, C., Bindereif, A., & Schneider, T. P. (2021) · Methods · doi:10.1016/j.ymeth.2021.04.014 · Cited by 31
Emerging Mechanisms and Treatment Progress on Liver Metastasis of Colorectal Cancer
Zheng, W., Wu, F., Fu, K., Sun, G., Sun, G., Li, X., Jiang, W., Cao, H., Wang, H., & Tang, W. (2021) · OncoTargets and Therapy · doi:10.2147/ott.s301371 · Cited by 30
The Roles of circRNAs in Intervertebral Disc Degeneration: Inflammation, Extracellular Matrix Metabolism, and Apoptosis
Li, H., Tian, L., Li, J., Li, Y., Du, L., Huo, Z., & Xu, B. (2022) · Analytical Cellular Pathology · doi:10.1155/2022/9550499 · Cited by 30
The interplay between noncoding RNA and YAP/TAZ signaling in cancers: molecular functions and mechanisms
Zhang, Y., Wang, Y., Ji, H., Ding, J., & Wang, K. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02403-4 · Cited by 33
circ_0003204 regulates the osteogenic differentiation of human adipose-derived stem cells via miR-370-3p/HDAC4 axis
Yu, L., Xia, K., Zhou, J., Hu, Z., Yin, X., Zhou, C., Zou, S., & Liu, J. (2022) · International Journal of Oral Science · doi:10.1038/s41368-022-00184-2 · Cited by 30
GCNCMI: A Graph Convolutional Neural Network Approach for Predicting circRNA-miRNA Interactions
He, J., Xiao, P., Chen, C., Zhu, Z., Zhang, J., & Deng, L. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.959701 · Cited by 30
Circular RNAs: Biogenesis, Biological Functions, and Roles in Myocardial Infarction
Li, J., Han, Y., Wang, S., Wu, X., Cao, J., & Sun, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044233 · Cited by 30
m 6 A-modification regulated circ-CCT3 acts as the sponge of miR-378a-3p to promote hepatocellular carcinoma progression
Liu, H., Jiang, Y., Lu, J., Peng, C., Ling, Z., Chen, Y., Chen, D., Tong, R., Zheng, S., & Wu, J. (2023) · Epigenetics · doi:10.1080/15592294.2023.2204772 · Cited by 30
The separation between the 5′-3′ ends in long RNA molecules is short and nearly constant
Leija-Martínez, N., Casas‐Flores, S., Cadena-Nava, R. D., Roca, J. A. I., Méndez, J. A. T., Gómez, E., & Ruiz-Garcia, J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1249 · Cited by 30
Circular RNAs and Plant Stress Responses
Litholdo, C. G., & da Fonseca, G. C. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-1426-1_27 · Cited by 30
The Drosophila X virus contains a 1-μM double-stranded RNA circularized by a 67-kd terminal protein: High-resolution denaturation mapping of its genome
Révet, B., & Delain, E. (1982) · Virology · doi:10.1016/0042-6822(82)90292-6 · Cited by 30
Circular RNAs: biology and clinical significance of breast cancer
Wang, Z., Deng, H., Yao, J., Luo, M., Huang, J., Wang, J., Zhang, K., Wang, L., & Zhou, J. (2023) · RNA Biology · doi:10.1080/15476286.2023.2272468 · Cited by 29
Non-coding RNAs as therapeutic targets in cancer and its clinical application
Leng, X., Zhang, M., Xu, Y., Wang, J., Ding, N., Yu, Y., Sun, S., Dai, W., Xue, X., Li, N., et al. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.02.001 · Cited by 31
Circular RNA regulatory role in pathological cardiac remodelling
Bibi, A., Barteková, M., Gandhi, S., Greco, S., Madè, A., Sarkar, M., Stopa, V., Tastsoglou, S., de Gonzalo‐Calvo, D., Devaux, Y., et al. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16434 · Cited by 30
Dynamic conformation: Marching toward circular RNA function and application
Liu, C., Yang, L. C., & Chen, L. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.08.020 · Cited by 30
Circular RNA hsa_circ_0078602 may have potential as a prognostic biomarker for patients with hepatocellular carcinoma
Kou, P., Zhang, C., Lin, J., & Wang, H. (2018) · Oncology Letters · doi:10.3892/ol.2018.9863 · Cited by 29
Identifying the sequence specificities of circRNA-binding proteins based on a capsule network architecture
Wang, Z., & Lei, X. (2021) · BMC Bioinformatics · doi:10.1186/s12859-020-03942-3 · Cited by 29
Insights Into the Involvement of Circular RNAs in Autoimmune Diseases
Zhai, X., Zhang, Y., Xin, S., Cao, P., & Lu, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.622316 · Cited by 29
Current advances and future perspectives on the functional roles and clinical implications of circular RNAs in esophageal squamous cell carcinoma: more influential than expected
Ju, C., He, J., Wang, C., Sheng, J., Jia, J., Du, D., Li, H., Zhou, M., & He, F. (2022) · Biomarker Research · doi:10.1186/s40364-022-00388-y · Cited by 29
Bioinformatics-based study reveals that AP2M1 is regulated by the circRNA-miRNA-mRNA interaction network and affects Alzheimer’s disease
Zhang, Q., Chen, B., Yang, P., Wu, J., Pang, X., & Pang, C.-Y. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1049786 · Cited by 31
Loops in Viroids
Ursula, W. I. L. D., Ramm, K., Sanger, H. L., & Riesner, D. (1980) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1980.tb04307.x · Cited by 29
Self-citation
Studies on encapsidated viroid-like RNA IV. requirement for infectivity and specificity of two RNA components from velvet tobacco mottle virus
Gould, A. R., Francki, R. I. B., & Randles, J. W. (1981) · Virology · doi:10.1016/0042-6822(81)90072-6 · Cited by 29
Circular RNA circPPP6R3 upregulates CD44 to promote the progression of clear cell renal cell carcinoma via sponging miR-1238-3p
Chen, Z., Zheng, Z., Xie, Y., Zhong, Q., Shangguan, W., Zhang, Y., Zhu, D., & Xie, W. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04462-5 · Cited by 28
Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway
Du, F., Wang, F., Wang, Y., Chen, J., Chen, S., Fan, L., Yang, L., Ren, Q., Duangmano, S., Du, F., et al. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02074-z · Cited by 28
Profiling and bioinformatics analyses reveal differential expression of circular RNA in tongue cancer revealed by high‐throughput sequencing
Qiu, X., Xu, K., Ma, H., Han, L., Chen, Q., Zhang, S., Da, P., & Wu, H. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27695 · Cited by 28
Identification and characterization of circular RNAs in Ganoderma lucidum
Shao, J., Wang, L., Liu, X., Yang, M., Chen, H., Wu, B., & Liu, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-52932-w · Cited by 26
Roles of circular RNAs in regulating the self-renewal and differentiation of adult stem cells
Wang, Y., Jiang, Z., Yu, M., & Yang, G. (2020) · Differentiation · doi:10.1016/j.diff.2020.03.001 · Cited by 28
CircRNA0001859, a new diagnostic and prognostic biomarkers for COPD and AECOPD
Chen, S., Yao, Y., Lü, S., Chen, J., Yang, G., Tu, L., & Chen, L. (2020) · BMC Pulmonary Medicine · doi:10.1186/s12890-020-01333-1 · Cited by 28
Circular RNA circANKS1B acts as a sponge for miR‐152‐3p and promotes prostate cancer progression by upregulating TGF‐α expression
Tao, L., Pan, X., Wang, J., Zhang, L., Tao, L., & Liang, C. Y. (2021) · The Prostate · doi:10.1002/pros.24102 · Cited by 28
NMFCDA: Combining randomization-based neural network with non-negative matrix factorization for predicting CircRNA-disease association
Wang, L., You, Z., Zhou, X., Yan, X., Li, H., & Huang, Y. (2021) · Applied Soft Computing · doi:10.1016/j.asoc.2021.107629 · Cited by 28
Decoding the complexity of circular RNAs in cardiovascular disease
Rai, A. K., Lee, B., Hebbard, C., Uchida, S., & Garikipati, V. N. S. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105766 · Cited by 28
Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA
Zhao, M., Wang, Y., Tan, F., Liu, L., Hou, X., Fan, C., Tang, L., Mo, Y., Wang, Y., Yan, Q., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2089-8 · Cited by 28
Expression profile of circRNA in peripheral blood mononuclear cells of patients with rheumatoid arthritis
Lu, H., Yang, Y., Kuang, D., Liu, P., & Yang, J. (2022) · BMC Medical Genomics · doi:10.1186/s12920-022-01225-9 · Cited by 28
Extracellular Vesicles Derived circSH3PXD2A Inhibits Chemoresistance of Small Cell Lung Cancer by miR-375-3p/YAP1
Chao, F., Zhang, Y., Lv, L., Wei, Y., Dou, X., Chang, N., Yi, Q., & Li, M. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s407116 · Cited by 28
Mapping studies of the Peach latent mosaic viroid reveal novel structural features
Dubé, A., Bolduc, F., Bisaillon, M., & Perreault, J. (2011) · Molecular Plant Pathology · doi:10.1111/j.1364-3703.2010.00703.x · Cited by 28
The Function of ncRNAs in Rheumatic Diseases
Chen, W., Liu, D., Li, Q., & Zhu, H. (2019) · Epigenomics · doi:10.2217/epi-2018-0135 · Cited by 28
Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery
Wang, Y., Shang, F., Liu, W., Jia, C., Luo, L., Wang, H., Min, X., Xu, J.-H., Ma, L., & Yang, X.-M. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.262589 · Cited by 28
Circular RNA in gastric cancer
Li, X., Yang, W., & Xu, J. (2020) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000908 · Cited by 28
Circular Ribozymes Generated in Escherichia coli Using Group I Self-splicing Permuted Intron-Exon Sequences
Puttaraju, M., & Been, M. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.26081 · Cited by 28
The potential role of circular RNAs -regulated PI3K signaling in non-small cell lung cancer: Molecular insights and clinical perspective
Kahkesh, S., Khoshnazar, S. M., Gholinezhad, Y., Esmailzadeh, S., Hosseini, S. A., Alimohammadi, M., & Mafi, A. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155316 · Cited by 28
Viroid RNA turnover: characterization of the subgenomic RNAs of potato spindle tuber viroid accumulating in infected tissues provides insights into decay pathways operating in vivo
Minoia, S., Navarro, B., Delgado, S., Serio, F. D., & Flores, R. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv034 · Cited by 27

Authors: Sanger, H. L., Klotz, G., Riesner, D., Gross, H. J., & Kleinschmidt, A. K.
Affiliations: Justus-Liebig-Universität Gießen (DE)
Universität Ulm (DE)
Max Planck Institute of Biochemistry (DE)
ORCID: Gross, H J
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1976-11
Volume: 73
Issue: 11
Pages: 3852-3856
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.73.11.3852
PMC: PMC431239
OpenAlex: W2031593782
Cited by: 2,296
References: 27
Citations by year: 2026: 70 · 2025: 180 · 2024: 238 · 2023: 215 · 2022: 316 · 2021: 323 · 2020: 298 · 2019: 168 · 2018: 125 · 2017: 72 · 2016: 36 · 2015: 27 · 2014: 16 · 2013: 6 · 2012: 7
FWCI: 22.41
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Virus Research Studies
Life Sciences › Immunology and Microbiology › Virology › Plant and Fungal Interactions Research
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: viroids, circular RNA, single-stranded RNA, rod structures, base pairing, thermal stability, citrus exocortis viroid, potato spindle tuber viroid, molecular weight
MeSH terms: Centrifugation, Hydrogen Bonding, Microscopy, Electron, Molecular Weight, Nucleic Acid Conformation, Nucleic Acid Denaturation, Plant Diseases, Plant Viruses, Plants, Ribonucleotides, RNA

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks