The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Dopamine receptors in human and calf brains, using [3H]apomorphine and an antipsychotic drug.
Open accessAbstract
In order to develop a better dopamine receptor radioligand, [3H[apomorphine was prepared and tested for dopamine-like binding properties in both calf and human brain tissues. Specific binding of [3H]apomorphine was defined as that binding which occurred in the presence of 1 muM (-)-butaclamol (an inactive neuroleptic) minus that occurring in the presence of 1 muM (+)-butaclamol (active neuroleptic). The specific binding was saturable, the number of sites being double that of specific [3H]dopamine binding, and occurred primarily in dopamine-rich regions of postmortem human brains. The binding had a dissociation constant of 0.9 nM for human caudate (2 nM for calf caudate) and was blocked by dopamine and norepinephrine, but not by isoproterenol or (-)-propranolol, distinguishing it from a beta-adrenergic receptor. Since there was little desorption of [3H]apomorphine, the ligand permits extensive washing during routine assays for dopamine receptors, and facilitates biochemical purification of the receptor.
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Citations
Cites
Yung-Chi, C., & Prusoff, W. H. (1973) · Biochemical Pharmacology · doi:10.1016/0006-2952(73)90196-2 · Cited by 12,922
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs
Creese, I., Burt, D. R., & Snyder, S. H. (1976) · Science · doi:10.1126/science.3854 · Cited by 2,220
Antipsychotic drug doses and neuroleptic/dopamine receptors
SEEMAN, P., LEE, T., CHAU-WONG, M., & WONG, K. (1976) · Nature · doi:10.1038/261717a0 · Cited by 1,622
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High densities of benzodiazepine receptors in human cortical areas
BRAESTRUP, C., ALBRECHTSEN, R., & SQUIRES, R. F. (1977) · Nature · doi:10.1038/269702a0 · Cited by 414
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Corlett, P. R., Honey, G. D., & Fletcher, P. C. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107077716 · Cited by 227
Metadata
- Authors
- Seeman, P., Chau-Wong, M., Tedesco, J., & Wong, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-12
- Volume
- 73
- Issue
- 12
- Pages
- 4354-4358
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2122237944
- Cited by
- 160
- References
- 3
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Open access
- green
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- Seeman, P., Chau-Wong, M., Tedesco, J., & Wong, K. (1976). Dopamine receptors in human and calf brains, using [3H]apomorphine and an antipsychotic drug. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.12.4354
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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