The DOI matches its Crossref record.
Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts.
Open accessAbstract
We have isolated the major cell surface glycoprotein of chick embryo fibroblasts, CSP, and added it to a variety of transformed cells in vitro. The transformed cells become more elongated, often more flattened, and show increased adhesion to the substratum. Several transformed cell lines also align in striking parallel arrays. This alignment is characterized by a decrease in the amount of nuclear overlapping, probably indicating restoration of contact inhibition of movement. The morphological changes are antagonized by antibody to CSP. These effects of CSP are not associated with an elevation of cellular 3':5'-cyclic AMP. Moreover, the morphological reversion is not accompanied by an alteration in growth properties. Our results are consistent with a role for CSP in cell adhesion and morphology but not in growth control.
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Cited by
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton
Burridge, K., Fath, K., Kelly, T., Nuckolls, G., & Turner, C. (1988) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.04.110188.002415 · Cited by 2,120
Binding of soluble form of fibroblast surface protein, fibronectin, to collagen
Engvall, E., & Ruoslahti, E. (1977) · International Journal of Cancer · doi:10.1002/ijc.2910200102 · Cited by 1,947
Ali, I. U., Mautner, V., Lanza, R., & Hynes, R. O. (1977) · Cell · doi:10.1016/0092-8674(77)90322-1 · Cited by 423
Qian, Y., Baisden, J. M., Zot, H. G., Van Winkle, W. B., & Flynn, D. C. (2000) · Experimental Cell Research · doi:10.1006/excr.1999.4795 · Cited by 51
Metadata
- Authors
- Yamada, K. M., Yamada, S. S., & Pastan, I.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-04
- Volume
- 73
- Issue
- 4
- Pages
- 1217-1221
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2004699574
- Cited by
- 509
- References
- 0
- FWCI
- 45.58
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts. https://app.cochat.ai/papers/10.1073/pnas.73.4.1217
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- Yamada, K. M., Yamada, S. S., & Pastan, I. (1976). Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.4.1217
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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