The DOI matches its Crossref record.
Solenoidal model for superstructure in chromatin.
Open accessAbstract
Chromatin prepared by brief digestion of nuclei with micrococcal nuclease, and extracted in 0.2 mM EDTA, appears in the electron microscope as filaments of about 100 A diameter which coil loosely. In 0.2 mM Mg++ these "nucleofilaments" condense into a supercoil or solenoidal structure of pitch about 110 A corresponding to the diameter of a nucleofilament. It is proposed that the x-ray reflections at orders of 110 A observed in chromatin originate in the spacing between turns of the solenoid rather than that between nucleosomes along the nucleofilament. The solenoidal structure appears to need histone H1 for its stabilization. Under certain conditions, isolated nucleosomes can also aggregate into a similar structure. The solenoidal structure can be correlated with the "thread" of diameter about 300 A observed by other workers in nuclei.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Crystal structure of the nucleosome core particle at 2.8 Å resolution
Luger, K., Mäder, A. W., Richmond, R. K., Sargent, D. F., & Richmond, T. J. (1997) · Nature · doi:10.1038/38444 · Cited by 9,466
Chromatin Fibers Are Formed by Heterogeneous Groups of Nucleosomes In Vivo
Ricci, M. A., Manzo, C., García-Parajo, M. F., Lakadamyali, M., & Cosma, M. P. (2015) · Cell · doi:10.1016/j.cell.2015.01.054 · Cited by 736
Resolving the 3D Landscape of Transcription-Linked Mammalian Chromatin Folding
Hsieh, T.-H. S., Cattoglio, C., Slobodyanyuk, E., Hansen, A. S., Rando, O. J., Tjian, R., & Darzacq, X. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.03.002 · Cited by 661
Nucleosome Arrays Reveal the Two-Start Organization of the Chromatin Fiber
Dorigo, B., Schalch, T., Kulangara, A., Duda, S., Schroeder, R. R., & Richmond, T. J. (2004) · Science · doi:10.1126/science.1103124 · Cited by 561
Mechanisms and Consequences of Double‐Strand DNA Break Formation in Chromatin
Cannan, W. J., & Pederson, D. S. (2016) · Journal of Cellular Physiology · doi:10.1002/jcp.25048 · Cited by 499
“Chromatin associated with transcriptionally active regions is generally in a relatively “open” or extended configuration, commonly referred to as a 10nm filament (orfiber) (Olins andOlins, 1974;Oudet et al., 1975; Finch and Klug, 1976; Woodcock et al., 1976).”
Background
Metadata
- Authors
- Finch, J. T., & Klug, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-06
- Volume
- 73
- Issue
- 6
- Pages
- 1897-1901
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2018626566
- Cited by
- 1,245
- References
- 0
- FWCI
- 23.50
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Solenoidal model for superstructure in chromatin. https://app.cochat.ai/papers/10.1073/pnas.73.6.1897
- The paper
- Finch, J. T., & Klug, A. (1976). Solenoidal model for superstructure in chromatin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.6.1897
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
