The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Selenium is an essential trace nutrient for growth of WI-38 diploid human fibroblasts.
Open accessAbstract
The trace element selenium is essential for clonal growth of diploid fibroblasts from human fetal lung (WI-38) in media containing small amounts of serum protein. Maximum growth stimulation is obtained when 30 nM neutralized selenious acid is added to a synthetic medium containing 1.5 mg/ml of dialyzed fetal bovine serum protein (equivalent to a 3% serum concentration). Serum appears to be a source of selenium in most culture media, since higher concentrations of serum protein or whole serum mask the selenium requirement of WI-38 cells. Selenium is also required by a Chinese hamster cell line that can be grown in a protein-free synthetic culture medium.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Clonal growth of mammalian cells in a chemically defined, synthetic medium
Ham, R. G. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.53.2.288 · Cited by 837
Self-citation
Cited by
Growth of a rat neuroblastoma cell line in serum-free supplemented medium.
Bottenstein, J. E., & Sato, G. H. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.514 · Cited by 2,276
Burk, R. F., & Hill, K. E. (2005) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132120 · Cited by 577
Iscove, N. N., & Melchers, F. (1978) · The Journal of experimental medicine · doi:10.1084/jem.147.3.923 · Cited by 531
Clonal growth of normal human epidermal keratinocytes in a defined medium
Tsao, M. C., Walthall, B. J., & Ham, R. G. (1982) · Journal of Cellular Physiology · doi:10.1002/jcp.1041100217 · Cited by 434
Self-citationSelenium in human health and disease with emphasis on those aspects peculiar to New Zealand
Thomson, C. D., & Robinson, M. F. (1980) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.2.303 · Cited by 307
Metadata
- Authors
- McKeehan, W. L., Hamilton, W. G., & Ham, R. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-06
- Volume
- 73
- Issue
- 6
- Pages
- 2023-2027
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2078517933
- Cited by
- 242
- References
- 1
- FWCI
- 11.37
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Selenium is an essential trace nutrient for growth of WI-38 diploid human fibroblasts. https://app.cochat.ai/papers/10.1073/pnas.73.6.2023
- The paper
- McKeehan, W. L., Hamilton, W. G., & Ham, R. G. (1976). Selenium is an essential trace nutrient for growth of WI-38 diploid human fibroblasts. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.6.2023
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
