The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins.
Open accessAbstract
The hypophysial homomeric peptide beta-lipotropin (beta-LPH-[1-91]) has no morphinomomimetic activity in a bioassay (myenteric plexus-longitudinal muscle of the guinea pig's ileum) or binding assays with stereospecific opiate-receptors of rat brain synaptosome preparations. Incubating beta-LPH-[1-91] at neutral pH with the supernatant aqueous extracts of rat brain generates (fragments of beta-LPH with) morphinomimetic activity in the same assay systems. These results are related to the recently recognized structural relationships between beta-LPH, the newly isolated peptides met-enkephalin (beta-LPH-[61-65]) and alpha-endorphin (beta-LPH-[61-76]) and also to the biologically active fragments of analogs: beta-LPH-[61-64], beta-LPH-[61-65[-NH2, (Met(O)65)-BETA-LPH-[61-65], beta-LPH-[61-69], and beta-LPH-[61-69]. Enzymatic biogenesis of these morphinomimetic peptides would preclude localizing them as such in cellular or subcellular elements with currently available methodology.
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Citations
Cites
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806
Cited by
Endogenous opioid peptides: multiple agonists and receptors
Lord, J. A. H., Waterfield, A. A., Hughes, J., & Kosterlitz, H. W. (1977) · Nature · doi:10.1038/267495a0 · Cited by 2,485
Peptides in the Brain: The New Endocrinology of the Neuron
Guillemin, R. (1978) · Science · doi:10.1126/science.212832 · Cited by 485
Self-citationThe C-Fragment of β-Lipotropin: An Endogenous Neuroleptic or Antipsychotogen?
Jacquet, Y. F., & Marks, N. (1976) · Science · doi:10.1126/science.185695 · Cited by 425
The role of endorphins in stress: Evidence and speculations
Amir, S., Brown, Z. W., & Amit, Z. (1980) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(80)90027-5 · Cited by 351
β-Endorphin as a potent analgesic by intravenous injection
TSENG, L.-F., LOH, H. H., & LI, C. H. (1976) · Nature · doi:10.1038/263239a0 · Cited by 280
Metadata
- Authors
- Lazarus, L. H., Ling, N., & Guillemin, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-06
- Volume
- 73
- Issue
- 6
- Pages
- 2156-2159
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2002607913
- Cited by
- 206
- References
- 1
- FWCI
- 15.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lazarus, L. H., Ling, N., & Guillemin, R. (1976). beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.6.2156
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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