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Autoregulation of simian virus 40 gene A by T antigen.
Open accessAbstract
During lytic infection by simian virus 40, gene A is transcribed into early RNA, which is translated into A protein (T antigen). Both the rate of synthesis and the intracellular amount of early RNA are higher in cells infected by temperature-sensitive A (tsA) mutants than in cells infected by wild-type virus. These differences are observed at permissive temperature (32 degrees) and are amplified greatly after a shift to restrictive temperature (41 degrees). For example, at 32 degrees cells infected by tsA mutants synthesize early RNA approximately twice as fast as cells infected by wild-type virus. After the shift to 41 degrees, the rate of synthesis in the tsA infection increases to 15 times the rate in the wild-type infection. In contrast, cells infected by tsA mutants do not overproduce late RNA. We suggest that the A protein regulates its own synthesis by negative feedback control of gene A transcription.
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Citations
Cited by
Dynan, W. S., & Tjian, R. (1983) · Cell · doi:10.1016/0092-8674(83)90210-6 · Cited by 1,445
In vivo sequence requirements of the SV40 early promoter region
Benoist, C., & Chambon, P. (1981) · Nature · doi:10.1038/290304a0 · Cited by 1,074
Complete nucleotide sequence of SV40 DNA
Fiers, W., Contreras, R., Haegeman, G., Rogiers, R., Van de Voorde, A., Van Heuverswyn, H., Van Herreweghe, J., Volckaert, G., & Ysebaert, M. (1978) · Nature · doi:10.1038/273113a0 · Cited by 1,010
The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats
Felber, B. K., Paskalis, H., Kleinman-Ewing, C., Wong-Staal, F., & Pavlakis, G. N. (1985) · Science · doi:10.1126/science.2992082 · Cited by 516
Post-translational regulation of the 54K cellular tumor antigen in normal and transformed cells.
Oren, M., Maltzman, W., & Levine, A. J. (1981) · Molecular and Cellular Biology · doi:10.1128/mcb.1.2.101 · Cited by 489
Metadata
- Authors
- Reed, S. I., Stark, G. R., & Alwine, J. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1976-09
- Volume
- 73
- Issue
- 9
- Pages
- 3083-3087
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2081938019
- Cited by
- 240
- References
- 0
- FWCI
- 13.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Reed, S. I., Stark, G. R., & Alwine, J. C. (1976). Autoregulation of simian virus 40 gene A by T antigen. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.73.9.3083
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