The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary.
Open accessAbstract
beta-Endorphin and enkephalin in extracts of whole brain, various brain regions, adenohypophysis, and combined pars intermedia and neurohypophysis of the rat were measured by radioimmunoassay. In brain extracts, the immunoreactive substances were further separated according to molecular size by gel filtration. beta-Endorphin was found in the diencephalon but not in the hippocampus, cerebral cortex, cerebellum, and striatum. Enkephalin was found predominantly in the striatum and diencephalon. Attention is called to possible artifactual interference by myelin basic protein in the immunoassays for beta-endorphin in some regions of the brain. In the pituitary, enkephalin was mainly restricted to the pars intermedia-neurohypophysis. Neither adrenalectomy nor hypophysectomy significantly altered levels of beta-endorphin in brain extracts. Adrenalectomy increased the levels of beta-endorphin in adenohypophysis and pars intermedia-neurohypophysis; after adrenalectomy, enkephalin was also increased in the adenohypophysis but less so in the pars intermedia-neurohypophysis. These results show that brain endorphin levels are independent of pituitary endorphin levels; they suggest that beta-endorphin-containing neurons and those containing enkephalin constitute two separate groups of brain cells.
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Cites
Identification of two related pentapeptides from the brain with potent opiate agonist activity
Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A., & Morris, H. R. (1975) · Nature · doi:10.1038/258577a0 · Cited by 3,806
Cited by
Nucleotide sequence of cloned cDNA for bovine corticotropin-β-lipotropin precursor
Nakanishi, S., Inoue, A., Kita, T., Inoue, A., Nakamura, M., Chang, A. C. Y., Cohen, S. N., & Numa, S. (1979) · Nature · doi:10.1038/278423a0 · Cited by 1,762
β-Endorphin and Adrenocorticotropin Are Selected Concomitantly by the Pituitary Gland
Guillemin, R., Vargo, T., Rossier, J., Minick, S., Ling, N., Rivier, C., Vale, W., & Bloom, F. (1977) · Science · doi:10.1126/science.197601 · Cited by 1,419
Self-citationZieglgänsberger, W., French, E. D., Siggins, G. R., & Bloom, F. E. (1979) · Science · doi:10.1126/science.451610 · Cited by 607
Self-citationThe immunocytochemical localization of enkephalin in the central nervous system of the rat
Finley, J. C. W., Maderdrut, J. L., & Petrusz, P. (1981) · Journal of Comparative Neurology · doi:10.1002/cne.901980402 · Cited by 554
Endogenous opioids and social behavior
Panksepp, J., Herman, B. H., Vilberg, T., Bishop, P., & DeEskinazi, F. G. (1980) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(80)90036-6 · Cited by 531
Metadata
- Authors
- Rossier, J., Vargo, T. M., Minick, S., Ling, N., Bloom, F. E., & Guillemin, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-11
- Volume
- 74
- Issue
- 11
- Pages
- 5162-5165
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2023858395
- Cited by
- 452
- References
- 1
- FWCI
- 17.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Rossier, J., Vargo, T. M., Minick, S., Ling, N., Bloom, F. E., & Guillemin, R. (1977). Regional dissociation of beta-endorphin and enkephalin contents in rat brain and pituitary. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.74.11.5162
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