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Characterization of C-reactive protein and the complement subcomponent C1t as homologous proteins displaying cyclic pentameric symmetry (pentraxins).
Open accessAbstract
Partial amino acid sequences of rabbit C-reactive protein, a peptide derived from human C-reactive protein by cyanogen bromide cleavage, and the C1t subcomponent of the human complement component C1 have been determined. Extensive sequence homology between these proteins establish their evolutionary relationships. In addition, examination of C-reactive proteins by negative-stain electron microscopy revealed that the protein is composed of five subunits arranged in cyclic symmetry. This structure is similar to that reported for both C1t and the amyloid P-component. The extensive structural relationship suggests similar or overlapping functions and the term pentraxin is proposed to describe these homologous proteins.
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Citations
Cited by
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PTX3, A Prototypical Long Pentraxin, Is an Early Indicator of Acute Myocardial Infarction in Humans
Peri, G., Introna, M., Corradi, D., Iacuitti, G., Signorini, S., Avanzini, F., Pizzetti, F., Maggioni, A. P., Moccetti, T., Metra, M., et al. (2000) · Circulation · doi:10.1161/01.cir.102.6.636 · Cited by 425
The Major Receptor for C-Reactive Protein on Leukocytes Is Fcγ Receptor II
Bharadwaj, D., Stein, M.-P., Volzer, M., Mold, C., & Clos, T. W. D. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.4.585 · Cited by 391
C‐reactive protein and coronary heart disease: a critical review
Casas, J. P., Shah, T., Hingorani, A. D., Danesh, J., & Pepys, M. B. (2008) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2008.02015.x · Cited by 366
Metadata
- Authors
- Osmand, A. P., Friedenson, B., Gewurz, H., Painter, R. H., Hofmann, T., & Shelton, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-02
- Volume
- 74
- Issue
- 2
- Pages
- 739-743
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2011841989
- Cited by
- 372
- References
- 0
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Osmand, A. P., Friedenson, B., Gewurz, H., Painter, R. H., Hofmann, T., & Shelton, E. (1977). Characterization of C-reactive protein and the complement subcomponent C1t as homologous proteins displaying cyclic pentameric symmetry (pentraxins). Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.74.2.739
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
