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Structure of human serum lipoproteins inferred from compositional analysis.
Abstract
Analysis of the correlations between size and chemical composition of lipoproteins of normolipidemic human plasma shows that the structure of all circulating lipoproteins is consistent with a spherical model of radius r in which a spherical liquid core of cholesterol esters and triglycerides of radius = r --20.2 A is surrounded by a monolayer of cholesterol and phospholipids with closely hydrophobic ends on the surface of the core. The average molecular areas at this inner surface are Spl = 68.5 A2/molecule for phospholipids and Sc= 39.1 A2/molecule for cholesterol. The proteins are closely packed with the hydrophilic head groups of phospholipids at the outer surface of the particle, with S' pl = 62.7 A2/molecule for phospholipids and Saa = 15.6 A2/amino acid for proteins. The polar head group of free cholesterol does not participate in the packing of the outer layer and thus must be masked by proteins. Free cholesterol is distributed among the circulating lipoproteins--with the exception of very high density lipoprotein and perhaps chylomicrons--according to a thermodynamic equilibrium governed by the curvature of the surface of the particle.
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The free cholesterol ratio decreased to 7%±1% in HDL subclasses due to higher LCAT activity.
“the free cholesterol ratio decreased to 7%±1% in HDL subclasses due to the higher LCAT activity.20 27 28”
From Clinical diversity and molecular mechanism of VPS35L-associated Ritscher-Schinzel syndrome (2023) · cites this paper as [20]
The Phospholipid and cholesterol composition table (p. 2) lists free-cholesterol amounts for HDL2 and HDL3, so the paper addresses that part of the claim. It does not report a decrease to 7%±1% or attribute such a decrease to higher LCAT activity; searches for that figure and LCAT found no supporting passage. (LLM, conf=0.84)
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- [6]Scanu, A. M. & Kruski, A. W. (1975) International Encyclopedia of Pharmacology and Therapeutics (Pergamon, Oxford, England), Vol. 1, sect. 24, pp. 21–38.
- [8]Gaines, G. L., Jr. (1966) Insoluble Monolayer at Lipid-Gas Interfaces (Interscience, New York), pp. 257 and 260.
- [10]Bruckdorfer, K. R. & Graham, J. M. (1976) in Biological Membranes, eds. Chapman, D. & Wallach, D. F. H. (Academic Press, New York), Vol. 3, chap. 3, pp. 102–152.
- [11]La Mer, V. K. & Gruen, R. (1952) Trans. Faraday Soc. 48, 410-415.
- [12]Eisenberg, S. (1976) "Atherosclerosis reviews," in Lipoprotein Metabolism and Hyperlipidemia, eds. Paoletti, R. & Gotto, A. M., Jr. (Raven Press, New York), Vol. 1, pp. 23–60.
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Fainaru, M., Mahley, R. W., Hamilton, R. L., & Innerarity, T. L. (1982) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38102-5 · Cited by 156
Kolovou, G. D., Watts, G. F., Mikhailidis, D. P., Pérez-Martínez, P., Mora, S., Bilianou, H., Panotopoulos, G., Katsiki, N., Ooi, T. C., Lopez-Miranda, J., et al. (2019) · Current Vascular Pharmacology · doi:10.2174/1570161117666190507110519 · Cited by 61
Clinical diversity and molecular mechanism of VPS35L-associated Ritscher-Schinzel syndrome
Otsuji, S., Nishio, Y., Tsujita, M., Rio, M., Huber, C., Antón-Plágaro, C., Mizuno, S., Kawano, Y., Miyatake, S., Simon, M., et al. (2023) · Journal of Medical Genetics · doi:10.1136/jmg-2022-108602 · Cited by 19
Leichtle, A., Teupser, D., & Thiery, J. (2006) · Journal of the American College of Nutrition · doi:10.1080/07315724.2006.10719555 · Cited by 13
Metadata
- Authors
- Shen, B. W., Scanu, A. M., & Kézdy, F. J.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1977-03
- Volume
- 74
- Issue
- 3
- Pages
- 837-841
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 270
- References
- 0
- Language
- en
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