Alpha-tocopherol distribution in lipoproteins and anti-inflammatory effects differ between CHD-patients and healthy subjects
Abstract
OBJECTIVE: The purpose of this study was to investigate the dose-dependent effects of RRR-alpha-tocopherol supplementation in coronary heart disease (CHD) patients and healthy subjects on plasma alpha-tocopherol levels, plasma lipoprotein distribution, LDL oxidation, and inflammatory plasma markers. METHODS: 12 patients with coronary heart disease and 12 healthy subjects were supplemented with increasing dosages of RRR-alpha-tocopherol at 100, 200 and 400 mg/day for a period of 3 weeks per dose. Lipoproteins were separated by FPLC and ultracentrifugation. Alpha-tocopherol was measured by HPLC. Resistance of LDL to oxidation was determined by reading the absorption at 234 nm after CuCl2-induced oxidation. Clinical chemistry and inflammatory markers were measured on automated analysis systems. RESULTS: Plasma alpha-tocopherol concentrations at baseline were comparable between CHD-patients and healthy subjects (21.7 +/- 4.7 micromol/L and 25.8 +/- 7.6 micromol/L, respectively). CHD-patients showed a significant increase (59%) of plasma alpha-tocopherol concentrations to 34.6 +/- 9.8 micromol/L at a dosage of 100 mg/day RRR-alpha-tocopherol, whereas healthy subjects showed a significant (54%) increase to 39.7 +/- 6.1 micromol/L only with 400 mg/day RRR-alpha-tocopherol. In addition, CHD-patients showed a significantly increased enrichment of alpha-tocopherol in VLDL. Supplementation (200 mg/day) caused a significant decrease of the acute phase plasma proteins C-reactive protein (CRP) (-65%) and fibrinogen (-24%). CONCLUSION: Our data demonstrate that CHD-patients require lower dosages of alpha-tocopherol supplementation than healthy subjects to exert biological effects on plasma lipoproteins and acute phase response.
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TAG, SFA, oxysterols, and glucose appear to be the most efficient triggers of the postprandial inflammatory response.
“The most efficient triggers of the postprandial inflammatory response appear to be TAG, SFA, oxysterols and glucose (158 -161) .”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [161]
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Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · see citing works
- Authors
- Leichtle, A., Teupser, D., & Thiery, J.
- Affiliations
- University Hospital Leipzig (DE)
- Corresponding author
- Teupser, Daniel
- Venue
- Journal of the American College of Nutrition
- Publisher
- Informa UK Limited
- Published
- 2006-10
- Volume
- 25
- Issue
- 5
- Pages
- 420-428
- ISSN
- 0731-5724 (ISSN-L)
- 1541-1087
- OpenAlex
- W2083269035
- Cited by
- 13
- References
- 36
- Citations by year
- 2018: 1 · 2015: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American College of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- alpha-tocopherol, vitamin E supplementation, coronary artery disease, lipoprotein distribution, LDL oxidation, VLDL, C-reactive protein, fibrinogen, acute phase response, dose-response relationship, anti-inflammatory activity
- MeSH terms
- Acute-Phase Reaction, Antioxidants, C-Reactive Protein, Cardiovascular Diseases, Chromatography, High Pressure Liquid, Chromatography, Liquid, Dose-Response Relationship, Drug, Female, Fibrinogen, Humans, Lipoproteins, Lipoproteins, LDL, Lipoproteins, VLDL, Male, Oxidation-Reduction, Stereoisomerism, Dietary Supplements, alpha-Tocopherol
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