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Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation.
Open accessAbstract
Rat immunoglobulin E (IgE) was treated with a crosslinking reagent, dimethyl suberimidate, and fractionated by gel filtration into monomers, dimers, trimers, and higher polymers. The fractions retained substantial ability to bind specifically to mast cells. About one-third of the cell-bound dimers appeared to bind bivalently. The fractions were assayed in vivo by passive cutaneous anaphylaxis in rats, and for histamine or serotonin release in vitro using normal or tumor mouse mast cells. The monomers showed no activity, while the dimers and higher polymers gave excellent and approximately equivalent responses. We conclude that IgE that has been crosslinked to form dimers prior to the addition to mast cells can serve as a unit signal for triggering IgE-mediated exocytosis.
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Citations
Cited by
Daëron, M. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.203 · Cited by 1,227
VALENTA, LIDHOLM, NIEDERBERGER, HAYEK, KRAFT, & GRÖNLUND (1999) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1999.00653.x · Cited by 531
Direct demonstration that receptor crosslinking or aggregation is important in insulin action
Kahn, C. R., Baird, K. L., Jarrett, D. B., & Flier, J. S. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.9.4209 · Cited by 389
Nanomagnetic actuation of receptor-mediated signal transduction
Mannix, R. J., Kumar, S., Cassiola, F., Montoya-Zavala, M., Feinstein, E., Prentiss, M., & Ingber, D. E. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2007.418 · Cited by 323
Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look
Davydov, M., & Krikorian, A. D. (2000) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(00)00181-1 · Cited by 256
Metadata
- Authors
- Segal, D. M., Taurog, J. D., & Metzger, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-07
- Volume
- 74
- Issue
- 7
- Pages
- 2993-2997
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2039634043
- Cited by
- 364
- References
- 0
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Segal, D. M., Taurog, J. D., & Metzger, H. (1977). Dimeric immunoglobulin E serves as a unit signal for mast cell degranulation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.74.7.2993
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
