Isolation, characterization, and synthesis of a corticotropin-inhibiting peptide from human pituitary glands
Open accessAbstract
A corticotropin-inhibiting peptide (CIP) has been isolated from human pituitary extracts. It consists of 32 amino acids with a proposed sequence identical to residues 7--38 of corticotropin (ACTH). The peptide has been synthesized by the solid-phase method. The melanotropic activity of the peptide is estimated to be 30% of the potency of ACTH. It is devoid of corticosteroidogenic activity but is able to inhibit ACTH-stimulated corticosterone production in isolated rat adrenal cells.
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Li et al. isolated ACTH [8-39] from human pituitary and showed it has ACTH antagonistic effects in vitro, naming it corticotrophin-inhibiting peptide (CIP).
“Li et al. isolated a naturally occurring peptide, ACTH [8–39], from human pituitary, which they showed to have ACTH antagonistic effects in vitro, and they called this corticotrophin-inhibiting peptide (CIP) (51).”
From ACTH Antagonists (2016) · cites this paper as [51]
The paper reports isolating a peptide from human pituitary glands, demonstrating ACTH-inhibiting activity in vitro, and naming it corticotropin-inhibiting peptide (CIP). But it identifies the peptide as ACTH-(7–38), not ACTH-(8–39) (opening passage; Results and Discussion). (LLM, conf=0.92)
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- Authors
- Li, C. H., Chung, D., Yamashiro, D., & Lee, C. Y.
- ORCID
- Chung, D
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1978-09
- Volume
- 75
- Issue
- 9
- Pages
- 4306-4309
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC336102
- OpenAlex
- W2034414253
- Cited by
- 71
- References
- 20
- Citations by year
- 2025: 1 · 2016: 2 · 2014: 4
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Keywords
- ACTH, human pituitary, peptide isolation, peptide synthesis, corticosterone production, adrenal cells, corticosteroid synthesis, ACTH fragments
- MeSH terms
- Adrenocorticotropic Hormone, Amino Acids, Biological Assay, Corticosterone, Humans, Melanocytes, Peptide Fragments, Peptides, Pituitary Gland
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