The DOI matches its Crossref record.
Cellular localization of the insect prothoracicotropic hormone: In vitro assay of a single neurosecretory cell
Open accessAbstract
The distribution of prothoracicotropic hormone in the pupal brain of Manduca sexta has been determined by an in vitro assay for prothoracic gland activation. Prothoracicotropic activity was observed in both the brain and retrocerebral complex, but predominantly in the dorosolateral regions of the protocerebrum. Of the two groups of neurosecretory cells present in this area of the brain, only the two lateral type III neurosecretory cells exhibited significant prothoracicotropic hormone activity. Further analysis revealed that the neurohormone was localized in only one of the two type III cells, suggesting that a single neurosecretory cell in each hemisphere is the source of the hormone at the stage examined (day 0). Prothoracicotropic hormone activity was detected in both the corpora allata and the corpora cardiaca, but the corpora allata contained 2 to 9 times the activity of the corpora cardiaca, depending on developmental stage. The significantly higher level of activity in the corpora allata suggests that they may be the neurohemal organs through which the prothoracicotropic hormone of Manduca is released.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Control and biochemical nature of the ecdysteroidogenic pathway
Gilbert, L. I., Rybczynski, R., & Warren, J. T. (2002) · Annual Review of Entomology · doi:10.1146/annurev.ento.47.091201.145302 · Cited by 532
Prothoracicotropic Hormone Regulates Developmental Timing and Body Size in Drosophila
McBrayer, Z., Ono, H., Shimell, M., Parvy, J.-P., Beckstead, R. B., Warren, J. T., Thummel, C. S., Dauphin-Villemant, C., Gilbert, L. I., & O'Connor, M. B. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.11.003 · Cited by 434
Self-citationRegulation of ecdysone production in Drosophila by neuropeptides and peptide hormones
Kannangara, J. R., Mirth, C. K., & Warr, C. G. (2021) · Open Biology · doi:10.1098/rsob.200373 · Cited by 84
Metadata
- Authors
- Agui, N., Granger, N. A., Gilbert, L. I., & Bollenbacher, W. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1979-11
- Volume
- 76
- Issue
- 11
- Pages
- 5694-5698
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2084532616
- Cited by
- 167
- References
- 0
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cellular localization of the insect prothoracicotropic hormone: In vitro assay of a single neurosecretory cell. https://app.cochat.ai/papers/10.1073/pnas.76.11.5694
- The paper
- Agui, N., Granger, N. A., Gilbert, L. I., & Bollenbacher, W. E. (1979). Cellular localization of the insect prothoracicotropic hormone: In vitro assay of a single neurosecretory cell. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.76.11.5694
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
