Cited by 532Neurobiology and Insect Physiology ResearchSteroid Chemistry and BiochemistryLipid metabolism and biosynthesis

Control and biochemical nature of the ecdysteroidogenic pathway

Gilbert, Lawrence I., Rybczynski, Robert, Warren, James T.·2002·Annual Review of Entomology

Abstract

Molting is elicited by a critical titer of ecdysteroids that includes the principal molting hormone, 20-hydroxyecdysone (20E), and ecdysone (E), which is the precursor of 20E but also has morphogenetic roles of its own. The prothoracic glands are the predominate source of ecdysteroids, and the rate of synthesis of these polyhydroxylated sterols is critical for molting and metamorphosis. This review concerns three aspects of ecdysteroidogenesis: (a) how the brain neuropeptide prothoracicotropic hormone (PTTH) initiates a transductory cascade in cells of the prothoracic gland, which results in an increased rate of ecdysteroid biosynthesis (upregulation); (b) how the concentrations of 20E in the hemolymph feed back on the prothoracic gland to decrease rates of ecdysteroidogenesis (downregulation); and (c) how the prothoracic gland cells convert cholesterol to the precursor of E and then 20E, a series of reactions only now being understood because of the use of a combination of classical biochemistry and molecular genetics.

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Crossref · 10.1146/annurev.ento.47.091201.145302

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Authors
Gilbert, L. I., Rybczynski, R., & Warren, J. T.
Affiliations
University of North Carolina at Chapel Hill (US)
Venue
Annual Review of Entomology
Published
2002-01
Volume
47
Issue
1
Pages
883-916
ISSN
  • 0066-4170 (ISSN-L)
  • 1545-4487
OpenAlex
W2157228103
Cited by
532
References
185
Citations by year
2026: 15 · 2025: 20 · 2024: 16 · 2023: 14 · 2022: 14 · 2021: 21 · 2020: 32 · 2019: 20 · 2018: 11 · 2017: 13 · 2016: 20 · 2015: 21 · 2014: 31 · 2013: 28 · 2012: 26
FWCI
2.40
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Entomology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
ecdysteroid biosynthesis, 20-hydroxyecdysone, ecdysone, prothoracic gland, prothoracicotropic hormone, molting, metamorphosis, cholesterol conversion, steroidogenesis, insect endocrinology
MeSH terms
Animals, Insecta, Down-Regulation, Ecdysteroids

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