Control and biochemical nature of the ecdysteroidogenic pathway
Abstract
Molting is elicited by a critical titer of ecdysteroids that includes the principal molting hormone, 20-hydroxyecdysone (20E), and ecdysone (E), which is the precursor of 20E but also has morphogenetic roles of its own. The prothoracic glands are the predominate source of ecdysteroids, and the rate of synthesis of these polyhydroxylated sterols is critical for molting and metamorphosis. This review concerns three aspects of ecdysteroidogenesis: (a) how the brain neuropeptide prothoracicotropic hormone (PTTH) initiates a transductory cascade in cells of the prothoracic gland, which results in an increased rate of ecdysteroid biosynthesis (upregulation); (b) how the concentrations of 20E in the hemolymph feed back on the prothoracic gland to decrease rates of ecdysteroidogenesis (downregulation); and (c) how the prothoracic gland cells convert cholesterol to the precursor of E and then 20E, a series of reactions only now being understood because of the use of a combination of classical biochemistry and molecular genetics.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Plants produce ECs via mevalonic acid (MVA) and cholesterol.
“On the other hand, plants produce ECs via mevalonic acid (MVA) and cholesterol [21,22,115,116].”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [115]
Invertebrates cannot synthesize ECs; rather, they consume phytosterols and convert them into ECs.
“Additionally, invertebrates cannot synthesize ECs; rather, they consume phytosterols and convert them into ECs.”
From Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones (2022) · cites this paper as [115]
Cites
The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,442 · see citing works
Comprehensive insect physiology, biochemistry and pharmacology
(1985) · Journal of Insect Physiology · doi:10.1016/0022-1910(85)90117-9 · Cited by 4,819 · see citing works
Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*
Pratt, W. B., & Toft, D. O. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0303 · Cited by 1,791 · see citing works
Signal Transduction through MAP Kinase Cascades
Lewis, T. S., Shapiro, P. S., & Ahn, N. G. (1998) · Advances in cancer research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,746 · see citing works
Evidence for a clade of nematodes, arthropods and other moulting animals
Aguinaldo, A. M. A., Turbeville, J. M., Linford, L. S., Rivera, M. C., Garey, J. R., Raff, R. A., & Lake, J. A. (1997) · Nature · doi:10.1038/387489a0 · Cited by 1,609 · see citing works
Comprehensive insect physiology, biochemistry and pharmacology
Brooks, G. T. (1985) · Insect Biochemistry · doi:10.1016/0020-1790(85)90131-3 · Cited by 1,597 · see citing works
Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster
N�sslein-Volhard, C., Wieschaus, E. F., & Kluding, H. (1984) · Development Genes and Evolution · doi:10.1007/bf00848156 · Cited by 1,550 · see citing works
A Family of cAMP-Binding Proteins That Directly Activate Rap1
Kawasaki, H., Springett, G. M., Mochizuki, N., Toki, S., Nakaya, M., Matsuda, M., Housman, D. E., & Graybiel, A. M. (1998) · Science · doi:10.1126/science.282.5397.2275 · Cited by 1,360 · see citing works
Regulation of the acute production of steroids in steroidogenic cells
STOCCO, D. M., & CLARK, B. J. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-3-221 · Cited by 1,057 · see citing works
Koelle, M. R., Talbot, W. S., Segraves, W. A., Bender, M. T., Cherbas, P. T., & Hogness, D. S. (1991) · Cell · doi:10.1016/0092-8674(91)90572-g · Cited by 978 · see citing works
Functional ecdysone receptor is the product of EcR and Ultraspiracle genes
Yao, T., FORMAN, B. M., Jiang, Z., Cherbas, L., Chen, J.-D., McKeown, M., Cherbas, P. T., & Evans, R. M. (1993) · Nature · doi:10.1038/366476a0 · Cited by 947 · see citing works
Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster
J�rgens, G., Wieschaus, E. F., N�sslein-Volhard, C., & Kluding, H. (1984) · Development Genes and Evolution · doi:10.1007/bf00848157 · Cited by 683 · see citing works
Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones
Pratt, W. B. (1997) · Endocrine Reviews · doi:10.1210/er.18.3.306 · Cited by 641 · see citing works
Regulation of the acute production of steroids in steroidogenic cells
Stocco, D. M. (1996) · Endocrine Reviews · doi:10.1210/er.17.3.221 · Cited by 635 · see citing works
Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster
Wieschaus, E. F., N�sslein-Volhard, C., & J�rgens, G. (1984) · Development Genes and Evolution · doi:10.1007/bf00848158 · Cited by 556 · see citing works
Hormonal regulation in insects: facts, gaps, and future directions
GÄde, G., Hoffmann, K. H., & Spring, J. H. (1997) · Physiological Reviews · doi:10.1152/physrev.1997.77.4.963 · Cited by 552 · see citing works
Metamorphosis : postembryonic reprogramming of gene expression in amphibian and insect cells
Gilbert, L. I., Tata, J. R., & Atkinson, B. G. (1996) · Cited by 511 · see citing works
The juvenile hormones: historical facts and speculations on future research directions
Gilbert, L. I., A. Granger, N., & Roe, R. M. (2000) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(00)00034-5 · Cited by 436 · see citing works
Self-citationOro, A. E., McKeown, M., & Evans, R. M. (1990) · Nature · doi:10.1038/347298a0 · Cited by 406 · see citing works
Interaction of Steroid Hormone Receptors with the Transcription Initiation Complex
Beato, M., & Sánchez‐Pacheco, A. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-6-587 · Cited by 402 · see citing works
Arakane, F., King, S. R., Du, Y., Kallen, C. B., Walsh, L. P., Watari, H., Stocco, D. M., & Strauss, J. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32656 · Cited by 391 · see citing works
Peripheral benzodiazepine receptor in cholesterol transport and steroidogenesis
Papadopoulos, V., Amri, H., Boujrad, N., Cascio, C., Culty, M., Garnier, M., Hardwick, M., Li, H., Vidic, B., Brown, A. S., et al. (1997) · Steroids · doi:10.1016/s0039-128x(96)00154-7 · Cited by 386 · see citing works
Lipid Metabolism and Function in Insects
Gilbert, L. I. (1967) · Advances in insect physiology · doi:10.1016/s0065-2806(08)60208-8 · Cited by 327 · see citing works
Ecdysteroid titer during larval-pupal-adult development of the tobacco hornworm, Manduca sexta
Bollenbacher, W. E., Smith, S. L., Goodman, W. G., & Gilbert, L. I. (1981) · General and Comparative Endocrinology · doi:10.1016/0016-6480(81)90005-8 · Cited by 325 · see citing works
STUDIES ON THE NECESSITY OF THE BRAIN FOR THE INCEPTION OF INSECT METAMORPHOSIS
Kopeć, S. (1922) · Biological Bulletin · doi:10.2307/1536759 · Cited by 310 · see citing works
Chávez, V. M., Marqués, G., Delbecque, J. P., Kobayashi, K., Hollingsworth, M., Burr, J., Natzle, J. E., & O’Connor, M. B. (2000) · Development · doi:10.1242/dev.127.19.4115 · Cited by 297 · see citing works
Roles of ecdysone in Drosophila development
Garen, A., Kauvar, L. M., & Lepesant, J. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.11.5099 · Cited by 281 · see citing works
Temporal coordination of regulatory gene expression by the steroid hormone ecdysone.
Karim, F. D., & Thummel, C. S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05501.x · Cited by 257 · see citing works
Structure, Mechanism, and Regulation of Mammalian Adenylyl Cyclase
Hurley, J. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7599 · Cited by 240 · see citing works
Ecdysone metabolism and distribution during the pupal-adult development of Manduca sexta
Warren, J. T., & Gilbert, L. I. (1986) · Insect Biochemistry · doi:10.1016/0020-1790(86)90080-6 · Cited by 235 · see citing works
Molecular Cloning of the Bombyx mori Prothoracicotropic Hormone
Kawakami, A., Kataoka, H., Oka, T., Mizoguchi, A., Kimura-Kawakami, M., Adachi, T., Iwami, M., Nagasawa, H., Suzuki, A., & Ishizaki, H. (1990) · Science · doi:10.1126/science.2315701 · Cited by 231 · see citing works
Transcriptional regulation of steroid hydroxylase genes by corticotropin
John, M. E., John, M. C., Boggaram, V, Simpson, E. R., & Waterman, M. R. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.13.4715 · Cited by 217 · see citing works
Shea, M. J., King, D. L., Conboy, M. J., Mariani, B. D., & Kafatos, F. C. (1990) · Genes & Development · doi:10.1101/gad.4.7.1128 · Cited by 212 · see citing works
Jindra, M., Malone, F., Hiruma, K., & Riddiford, L. M. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0299 · Cited by 189 · see citing works
Henrich, V. C., Siiter, T. J., Lubahn, D. B., Maclntyre, A., & Gilbert, L. I. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.14.4143 · Cited by 176 · see citing works
Puglielli, L., Rigotti, A., Greco, A. V., Santos, M. J., & Nervi, F. O. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.32.18723 · Cited by 168 · see citing works
Agui, N., Granger, N. A., Gilbert, L. I., & Bollenbacher, W. E. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.11.5694 · Cited by 167 · see citing works
Riehle, M. A. (1999) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(99)00084-3 · Cited by 166 · see citing works
Identification of a Prothoracicostatic Peptide in the Larval Brain of the Silkworm, Bombyx mori
Hua, Y., Tanaka, Y., Nakamura, K., Sakakibara, M., Nagata, S., & Kataoka, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.44.31169 · Cited by 163 · see citing works
Unique Sterol in the Ecology and Nutrition of Drosophila pachea
Heed, W. B., & Kircher, H. W. (1965) · Science · doi:10.1126/science.149.3685.758 · Cited by 158 · see citing works
Yochem, J., Tuck, S., Greenwald, I., & Han, M. (1999) · Development · doi:10.1242/dev.126.3.597 · Cited by 155 · see citing works
Molecular Chaperones Activate the Drosophila Ecdysone Receptor, an RXR Heterodimer
Arbeitman, M. N., & Hogness, D. S. (2000) · Cell · doi:10.1016/s0092-8674(00)80624-8 · Cited by 154 · see citing works
S6 Phosphorylation and the p70 s6k /p85 s6k
Ferrari, S. M., & Thomas, G. (1994) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409239409083485 · Cited by 150 · see citing works
Peptide Hormones, Steroid Hormones, and Puffs: Mechanisms and Models in Insect Development
Henrich, V. C., Rybczynski, R., & Gilbert, L. I. (1998) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60934-6 · Cited by 141 · see citing works
Jindra, M., Huang, J., Malone, F., Asahina, M., & Riddiford, L. M. (1997) · Insect Molecular Biology · doi:10.1046/j.1365-2583.1997.00153.x · Cited by 139 · see citing works
Czar, M. J., Lyons, R. H., Welsh, M. J., Renoir, J., & Pratt, W. B. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.11.8584032 · Cited by 137 · see citing works
Endocrine Cascade in Insect Metamorphosis
Gilbert, L. I., Rybczynski, R., & Tobe, S. S. (1996) · Elsevier eBooks · doi:10.1016/b978-012283245-1/50004-x · Cited by 135 · see citing works
Warren, J. T., Sakurai, S., Rountree, D. B., Gilbert, L. I., Lee, S., & Nakanishi, K. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.3.958 · Cited by 135 · see citing works
The brain secretory peptides that control moulting and metamorphosis of the silkmoth, Bombyx mori
Ishizaki, H., & Suzuki, A. (1994) · The International Journal of Developmental Biology · doi:10.1387/ijdb.7981038 · Cited by 130 · see citing works
Dai, J.-D., & Gilbert, L. I. (1991) · Developmental Biology · doi:10.1016/0012-1606(91)90424-2 · Cited by 128 · see citing works
The cholesterol side-chain cleavage system of the adrenal cortex: A mixed-function oxidase
Simpson, E. R., & Boyd, G. S. (1966) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(66)90402-5 · Cited by 124 · see citing works
Mizoguchi, A., Ohashi, Y., Hosoda, K., Ishibashi, J., & Kataoka, H. (2001) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(00)00127-2 · Cited by 124 · see citing works
Alternative sites for ecdysteroid production in insects
Delbecque, J., WEIDNER, K., & Hoffmann, K. H. (1990) · Invertebrate Reproduction & Development · doi:10.1080/07924259.1990.9672126 · Cited by 123 · see citing works
Kralli, A., & Yamamoto, K. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.29.17152 · Cited by 123 · see citing works
Šauman, I., & Reppert, S. M. (1996) · Developmental Biology · doi:10.1006/dbio.1996.0228 · Cited by 123 · see citing works
Nakanishi, K., Koreeda, M., Sasaki, S., Chang, M. L., & Hsu, H. Y. (1966) · Chemical Communications (London) · doi:10.1039/c19660000915 · Cited by 121 · see citing works
Calcium-cyclic AMP interactions in prothoracicotropic hormone stimulation of ecdysone synthesis
Smith, W. T., GILBERT, L., & Bollenbacher, W. E. (1985) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(85)90093-0 · Cited by 121 · see citing works
The role of cyclic AMP in the regulation of ecdysone synthesis
Smith, W. A., Gilbert, L. I., & Bollenbacher, W. E. (1984) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(84)90098-4 · Cited by 121 · see citing works
Freeman, M. R., Dobritsa, A., Gaines, P., Segraves, W. A., & Carlson, J. R. (1999) · Development · doi:10.1242/dev.126.20.4591 · Cited by 119 · see citing works
Kiriishi, S., Rountree, D. B., Sakurai, S., & Gilbert, L. I. (1990) · Cellular and Molecular Life Sciences · doi:10.1007/bf01939944 · Cited by 115 · see citing works
The significance of moulting in Ecdysozoan evolution
Valentine, J. W., & Collins, A. G. (2000) · Evolution & Development · doi:10.1046/j.1525-142x.2000.00043.x · Cited by 112 · see citing works
Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer
Fortini, M., & Bonini, N. M. (2000) · Trends in Genetics · doi:10.1016/s0168-9525(99)01939-3 · Cited by 106 · see citing works
Graf, R., Neuenschwander, S., Brown, M. R., & Ackermann, U. (1997) · Insect Molecular Biology · doi:10.1111/j.1365-2583.1997.tb00083.x · Cited by 104 · see citing works
Early steps in ecdysteroid biosynthesis: Evidence for the involvement of cytochrome P-450 enzymes
Grieneisen, M. L., Warren, J. T., & Gilbert, L. I. (1993) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(93)90077-6 · Cited by 99 · see citing works
Molecular Aspects of Juvenile Hormone Action in Insect Metamorphosis
Riddiford, L. M. (1996) · Elsevier eBooks · doi:10.1016/b978-012283245-1/50008-7 · Cited by 96 · see citing works
Evolution of Insect Metamorphosis
Sehnal, F., Švácha, P., & Zrzavý, J. (1996) · Elsevier eBooks · doi:10.1016/b978-012283245-1/50003-8 · Cited by 94 · see citing works
Programmed cell death of the prothoracic glands of Manduca sexta during pupal-adult metamorphosis
Dai, J.-D., & Gilbert, L. I. (1997) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(96)00068-9 · Cited by 93 · see citing works
26-[125I]iodoponasterone A is a potent ecdysone and a sensitive radioligand for ecdysone receptors.
Cherbas, P. T., Cherbas, L., Lee, S., & Nakanishi, K. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.7.2096 · Cited by 89 · see citing works
The biosynthesis of steroids and triterpenoids
Brown, G. D. (1998) · Natural Product Reports · doi:10.1039/a815653y · Cited by 88 · see citing works
Czar, M. J., Owens-Grillo, J. K., Yem, A. W., Leach, K. L., Deibel, M. R., Welsh, M. J., & Pratt, W. B. (1994) · Molecular Endocrinology · doi:10.1210/mend.8.12.7708060 · Cited by 87 · see citing works
Neuropeptides, second messengers and insect molting
Gilbert, L. I., Combest, W. L., Smith, W. A., Meller, V. H., & Rountree, D. B. (1988) · BioEssays · doi:10.1002/bies.950080506 · Cited by 85 · see citing works
Ecdysteroids and related molecules in animals and plants
Lafont, R. (1997) · Archives of Insect Biochemistry and Physiology · doi:10.1002/(sici)1520-6327(1997)35:1/2 · Cited by 84 · see citing works
Metabolism of Steroids in Insects
Thompson, M. J., Kaplanis, J. N., Robbins, W. E., & Svoboda, J. A. (1973) · Advances in lipid research · doi:10.1016/b978-0-12-024911-4.50013-1 · Cited by 80 · see citing works
Molecular Aspects of Ecdysteroid Hormone Action
Cherbas, P. T., & Cherbas, L. (1996) · Elsevier eBooks · doi:10.1016/b978-012283245-1/50007-5 · Cited by 79 · see citing works
Mediation of ecdysone synthesis in Manduca sexta by a hemolymph enzyme
Sakurai, S., Warren, J. T., & Gilbert, L. I. (1989) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.940100303 · Cited by 75 · see citing works
Ishibashi, J., Kataoka, H., Isogai, A., Kawakami, A., Saegusa, H., Yagi, Y., Mizoguchi, A., Ishizaki, H., & Suzuki, A. (1994) · Biochemistry · doi:10.1021/bi00185a031 · Cited by 74 · see citing works
Hétru, C., Li, K. W., Bulet, P., Lagueux, M., & Hoffmann, J. A. (1991) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1991.tb16308.x · Cited by 73 · see citing works
Redfern, C. P. F. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.18.5643 · Cited by 71 · see citing works
Sakurai, S., & Williams, C. M. (1989) · General and Comparative Endocrinology · doi:10.1016/0016-6480(89)90072-5 · Cited by 71 · see citing works
Song, Q., & Gilbert, L. I. (1998) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(98)00075-7 · Cited by 71 · see citing works
Maintenance of the Prothoracic Gland by the Juvenile Hormone in Insects
Gilbert, L. I. (1962) · Nature · doi:10.1038/1931205a0 · Cited by 68 · see citing works
Variability of Metabolism and Function of Sterols in Insects
Svoboda, J. A. (1999) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409239991209183 · Cited by 67 · see citing works
Vafopoulou, X., & Steel, C. G. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3368 · Cited by 64 · see citing works
Rybczynski, R., & Gilbert, L. I. (1994) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(94)90084-1 · Cited by 63 · see citing works
Studies on the biosynthesis of ecdysone by the Y-organs of Carcinus maenas
Lachaise, F., Meister, M. F., Hétru, C., & Lafont, R. (1986) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(86)90155-3 · Cited by 62 · see citing works
Gu, S., Chow, Y., Lin, F., Wu, J., & Ho, R.-J. (1996) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(96)03821-x · Cited by 62 · see citing works
Synthesis and secretion of ecdysteroids by the prothoracic glands of Manduca sexta
Warren, J. T., Sakurai, S., Rountree, D. B., & Gilbert, L. I. (1988) · Journal of Insect Physiology · doi:10.1016/0022-1910(88)90061-3 · Cited by 61 · see citing works
Bassett, M. H., McCarthy, J. L., Waterman, M. R., & Sliter, T. J. (1997) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(97)00093-2 · Cited by 60 · see citing works
Insect prothoracic glands: a role for cyclic AMP in the stimulation of α-ecdysone secretion
Vedeckis, W. V., Bollenbacher, W. E., & Gilbert, L. I. (1976) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(76)90072-1 · Cited by 57 · see citing works
Wismar, J., Habtemichael, N., Warren, J. T., Dai, J.-D., Gilbert, L. I., & Gateff, E. A. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9811 · Cited by 57 · see citing works
Meller, V. H., Combest, W. L., Smith, W. A., & Gilbert, L. I. (1988) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(88)90196-7 · Cited by 57 · see citing works
Song, Q., & Gilbert, L. I. (1994) · Developmental Genetics · doi:10.1002/dvg.1020150404 · Cited by 56 · see citing works
Involvement of translation and transcription in insect steroidogenesis
Keightley, D. A., Lou, K. J., & Smith, W. A. (1990) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(90)90228-z · Cited by 56 · see citing works
Song, Q., & Gilbert, L. I. (1995) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(94)00100-v · Cited by 55 · see citing works
Feedback inhibition of ecdysone production by 20-hydroxyecdysone in Pieris brassicae pupae
Beydon, P., & Lafont, R. (1983) · Journal of Insect Physiology · doi:10.1016/0022-1910(83)90084-7 · Cited by 55 · see citing works
Gu, S., Chow, Y., & O’Reilly, D. R. (1998) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(98)00074-5 · Cited by 54 · see citing works
Woc (without children) gene control of ecdysone biosynthesis in Drosophila melanogaster
Warren, J. T., Wismar, J., Subrahmanyam, B., & Gilbert, L. I. (2001) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(01)00404-x · Cited by 54 · see citing works
Smith, W. A., Combest, W. L., & Gilbert, L. I. (1986) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(86)90012-2 · Cited by 51 · see citing works
Warren, J. T., Bachmann, J. A. S., Dai, J.-D., & Gilbert, L. I. (1996) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(96)00059-8 · Cited by 49 · see citing works
Characterization of Ecdysteroid 26-Hydroxylase: An Enzyme Involved in Molting Hormone Inactivation
Williams, D. R., Fisher, M. J., & Rees, H. H. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1731 · Cited by 48 · see citing works
Control of ecdysteroidogenesis: Activation and inhibition of prothoracic gland activity
Gilbert, L. I., Song, Q., & Rybczynski, R. (1997) · Invertebrate Neuroscience · doi:10.1007/bf02480376 · Cited by 48 · see citing works
Meister, M. F., Dimarcq, J., Kappler, C., Hétru, C., Lagueux, M., Lanot, R., Luu, B., & Hoffmann, J. A. (1985) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(85)90140-6 · Cited by 48 · see citing works
Rybczynski, R., & Gilbert, L. I. (2000) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(00)00031-x · Cited by 48 · see citing works
Gilbert, L. I., Rybczynski, R., Song, Q., Mizoguchi, A., Morreale, R. A., Smith, W. A., Matubayashi, H., Shionoya, M., Nagata, S., & Kataoka, H. (2000) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(00)00083-7 · Cited by 47 · see citing works
FKBP46, a novel Sf9 insect cell nuclear immunophilin that forms a protein-kinase complex.
Alnemri, E. S., Fernandes‐Alnemri, T., Pomerenke, K., Robertson, N. M., Dudley, K., DuBois, G. C., & Litwack, G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47356-5 · Cited by 46 · see citing works
A novel neuropeptide–endocrine interaction controlling ecdysteroid production in ixodid ticks
Lomas, L., Turner, P., & Rees, H. H. (1997) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1997.0084 · Cited by 46 · see citing works
An Immunophilin is a Component of the Insect Ecdysone Receptor (EcR) Complex
Song, Q., Alnemri, E. S., Litwack, G., & Gilbert, L. I. (1997) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(97)00080-5 · Cited by 45 · see citing works
Biosynthesis of sterols and ecdysteroids in <i>Ajuga</i> hairy roots
Fujimoto, Y., Ohyama, K., Nomura, K., Hyodo, R., Takahashi, K., Yamada, J., & Morisaki, M. (2000) · Lipids · doi:10.1007/s11745-000-0524-z · Cited by 45 · see citing works
Interaction of the progesterone receptor with binding proteins for FK506 and cyclosporin A
Milad, M. P., Sullivan, W., Diehl, E. E., Altmann, M., Nordeen, S. K., Edwards, D. P., & Toft, D. O. (1995) · Molecular Endocrinology · doi:10.1210/mend.9.7.7476967 · Cited by 45 · see citing works
A neuroendocrine releasing effect of melatonin in the brain of an insect, Periplaneta americana (L.)
Richter, K., Peschke, E., & Peschke, D. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2001.280301.x · Cited by 43 · see citing works
Ecdysone biosynthesis: Pathways, enzymes, and the early steps problem
Warren, J. T., & Hétru, C. (1990) · Invertebrate Reproduction & Development · doi:10.1080/07924259.1990.9672131 · Cited by 42 · see citing works
Yoshida, I., Moto, K., Sakurai, S., & Iwami, M. (1998) · Development Genes and Evolution · doi:10.1007/s004270050197 · Cited by 42 · see citing works
Smith, W. A., & Pasquarello, T. J. (1989) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(89)90100-7 · Cited by 40 · see citing works
Purification and characterization of the prothoracicotropic hormone of Drosophila melanogaster
Kim, A., Cha, G., Kim, K., Gilbert, L. I., & Lee, C. C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1130 · Cited by 39 · see citing works
The role of phytosterols in host plant utilization by cactophilicDrosophila
Fogleman, J. C., Duperret, S. M., & Kircher, H. W. (1986) · Lipids · doi:10.1007/bf02534309 · Cited by 39 · see citing works
Ecdysone Analog: Conversion to Alpha Ecdysone and 20-Hydroxyecdysone by an Insect
Kaplanis, J. N., Robbins, W. E., Thompson, M. J., & Baumhover, A. H. (1969) · Science · doi:10.1126/science.166.3912.1540 · Cited by 39 · see citing works
Winter, J., Bilbe, G., Richener, H., Sehringer, B., & Kayser, H. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0783 · Cited by 39 · see citing works
Grieneisen, M. L., Warren, J. T., Sakurai, S., & Gilbert, L. I. (1991) · Insect Biochemistry · doi:10.1016/0020-1790(91)90062-j · Cited by 38 · see citing works
Shirai, Y., Aizono, Y., Iwasaki, T., Yanagida, A., Mori, H., Sumida, M., & Matsubara, F. (1993) · Journal of Insect Physiology · doi:10.1016/0022-1910(93)90021-i · Cited by 37 · see citing works
Sakurai, S., Warren, J. T., & Gilbert, L. I. (1991) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.940180103 · Cited by 37 · see citing works
Evidence for the involvement of 3-oxo-Δ4 intermediates in ecdysteroid biosynthesis
Blais, C., Dauphin‐Villemant, C., Ковганко, Н. В., Girault, J., Descoins, C., & Lafont, R. (1996) · Biochemical Journal · doi:10.1042/bj3200413 · Cited by 37 · see citing works
Bollenbacher, W. E., Galbraith, M. N., Gilbert, L. I., & Horn, D. (1977) · Steroids · doi:10.1016/0039-128x(77)90108-8 · Cited by 37 · see citing works
Kayser, H., Wtnkler, T., & Spindler‐Barth, M. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.00707.x · Cited by 36 · see citing works
PURIFICATION AND PROPERTIES OF THE PROTHORACICOTROPIC HORMONE OF THE SILKWORM, BOMBYX MORI
Nagasawa, H., ISOGAI, A., Suzuki, A., Tamura, S., & Ishizaki, H. (1979) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.1979.00029.x · Cited by 35 · see citing works
Regulation of Membrane Cholesterol Domains by Sterol Carrier Protein-2
Hapala, I., Butko, P., Kavecansky, J., Scallen, T. J., Joiner, C. H., & Schroeder, F. (1994) · Biochemistry · doi:10.1021/bi00190a023 · Cited by 35 · see citing works
Snyder, M. J., & van Antwerpen, R. (1998) · Cell and Tissue Research · doi:10.1007/s004410051166 · Cited by 34 · see citing works
Vafopoulou, X., & Steel, C. G. H. (1997) · Journal of Insect Physiology · doi:10.1016/s0022-1910(97)00017-6 · Cited by 34 · see citing works
Chen, J., Turner, P., & Rees, H. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.15.10551 · Cited by 34 · see citing works
Neurosecretion: peptidergic systems in insects
Predel, R., & Eckert, M. (2000) · Die Naturwissenschaften · doi:10.1007/s001140050737 · Cited by 33 · see citing works
Warren, J. T., & Gilbert, L. I. (1996) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(96)00058-6 · Cited by 33 · see citing works
Rybczynski, R., & Gilbert, L. I. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1122 · Cited by 33 · see citing works
Metabolism of lathosterol byDrosophila pachea
Goodnight, K. C., & Kircher, H. W. (1971) · Lipids · doi:10.1007/bf02533031 · Cited by 33 · see citing works
Shirai, Y., Iwasaki, T., Matsubara, F., & Aizono, Y. (1994) · Journal of Insect Physiology · doi:10.1016/0022-1910(94)90119-8 · Cited by 32 · see citing works
Rybczynski, R., & Gilbert, L. I. (1995) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(95)03672-t · Cited by 32 · see citing works
A diazepam binding inhibitor (DBI) homolog from the tobacco hornworm, Manduca sexta
Snyder, M. J., & Feyereisen, R. (1993) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(93)90064-q · Cited by 32 · see citing works
Synthesis of a labelled putative precursor of ecdysone—II
Haag, T., Meister, M. F., Hétru, C., Kappler, C., Nakatani, Y., Beaucourt, J. P., Rousseau, B., & Luu, B. (1987) · Insect Biochemistry · doi:10.1016/0020-1790(87)90071-0 · Cited by 31 · see citing works
Radyuk, S. N., Klichko, V. I., & Orr, W. C. (2000) · Archives of Insect Biochemistry and Physiology · doi:10.1002/1520-6327(200010)45:2 · Cited by 31 · see citing works
The insect gut: A new source of ecdysiotropic peptides
Gelman, D. B., Thyagaraja, B. S., Kelly, T. J., Masler, E. P., Bell, R. A., & Bořkovec, A. B. (1991) · Cellular and Molecular Life Sciences · doi:10.1007/bf02041259 · Cited by 31 · see citing works
Koolman, J. (1978) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1978.359.2.1315 · Cited by 31 · see citing works
Cook, I. F., Lloyd-Jones, J. G., Rees, H. H., & Goodwin, T. W. (1973) · Biochemical Journal · doi:10.1042/bj1360135 · Cited by 31 · see citing works
Understanding insect endocrine systems: molecular approaches*
Lafont, R. (2000) · Entomologia Experimentalis et Applicata · doi:10.1046/j.1570-7458.2000.00723.x · Cited by 30 · see citing works
Meller, V. H., Sakurai, S., & Gilbert, L. I. (1990) · Cell Regulation · doi:10.1091/mbc.1.10.771 · Cited by 30 · see citing works
Stimulation of ecdysteroidogenesis by small prothoracicotropic hormone: role of calcium
Hayes, G. C., Muehleisen, D. P., Bollenbacher, W. E., & Watson, R. D. (1995) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(95)03679-2 · Cited by 30 · see citing works
Rountree, D. B., Combest, W. L., & Gilbert, L. I. (1987) · Insect Biochemistry · doi:10.1016/0020-1790(87)90100-4 · Cited by 29 · see citing works
Girgenrath, S., & Smith, W. A. (1996) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(96)00001-x · Cited by 29 · see citing works
Hanton, W. K., Watson, R. D., & Bollenbacher, W. E. (1993) · Journal of Morphology · doi:10.1002/jmor.1052160110 · Cited by 29 · see citing works
Cellular regulation of ecdysone synthesis by the prothoracic glands of Manduca sexta
Smith, W. A., & Gilbert, L. I. (1986) · Insect Biochemistry · doi:10.1016/0020-1790(86)90088-0 · Cited by 27 · see citing works
Morisaki, M., Ohtaka, H., Okubayashi, M., Ikekawa, N., Horie, Y., & Nakasone, S. (1972) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c39720001275 · Cited by 27 · see citing works
Warren, J. T., Rybczynski, R., & Gilbert, L. I. (1995) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(95)00007-i · Cited by 25 · see citing works
7-Dehydrosterols in prothoracic glands of the silkworm,Bombyx mori
Sakurai, S., Yonemura, N., Fujimoto, Y., HATA, F., & IKEKAWA, N. (1986) · Cellular and Molecular Life Sciences · doi:10.1007/bf01940720 · Cited by 25 · see citing works
Δ5, 7-Steroids. VI. The Preparation of Δ5, 7-Steroidal Hormones
Antonucci, R., Bernstein, S., Giancola, D., & Sax, K. J. (1951) · The Journal of Organic Chemistry · doi:10.1021/jo50001a016 · Cited by 25 · see citing works
Polyamines modulate multiple protein phosphorylation pathways in the insect prothoracic gland
Combest, W. L., & Gilbert, L. I. (1992) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(92)90190-h · Cited by 24 · see citing works
Bollenbacher, W. E., Faux, A. F., Galbraith, M. N., Gilbert, L. I., Horn, D., & Wilkie, J. S. N. (1979) · Steroids · doi:10.1016/s0039-128x(79)80013-6 · Cited by 22 · see citing works
Smith, W. A., Varghese, A. H., Healy, M. S., & Lou, K. J. (1996) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(95)00078-x · Cited by 21 · see citing works
Feldlaufer, M. F., Weirich, G. F., Lusby, W. R., & Svoboda, J. A. (1991) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.940180202 · Cited by 21 · see citing works
Henrich, V. C. (1995) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.940300212 · Cited by 20 · see citing works
Can the insect nervous system synthesize ecdysteroids?
Warren, J. T., Dai, J.-D., & Gilbert, L. I. (1999) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(99)00033-8 · Cited by 19 · see citing works
Rountree, D. B., Combrest, W. L., & Gilbert, L. I. (1992) · Insect Biochemistry and Molecular Biology · doi:10.1016/0965-1748(92)90073-n · Cited by 18 · see citing works
Manière, G., Vanhems, E., & Delbecque, J. (2000) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(00)00312-9 · Cited by 17 · see citing works
Early stages of ecdysteroid biosynthesis
Milner, N. P., Nali, M., Gibson, M., & Rees, H. H. (1986) · Insect Biochemistry · doi:10.1016/0020-1790(86)90073-9 · Cited by 17 · see citing works
Early stages of ecdysteroid biosynthesis: The role of 7-dehydrocholesterol
Milner, N. P., Nali, M., Gibson, M., & Rees, H. H. (1986) · Research Explorer (The University of Manchester) · Cited by 16 · see citing works
Birkenbeil, H. (2000) · Journal of Insect Physiology · doi:10.1016/s0022-1910(00)00064-0 · Cited by 15 · see citing works
Fujimoto, Y., Ikuina, Y., Nagakari, M., Kakinuma, S., & Ikekawa, N. (1990) · Journal of the Chemical Society Perkin Transactions 1 · doi:10.1039/p19900002041 · Cited by 14 · see citing works
Intracellular calcium in prothoracic glands of Manduca sexta
Birkenbeil, H. (1998) · Journal of Insect Physiology · doi:10.1016/s0022-1910(97)00115-7 · Cited by 14 · see citing works
Study oh the biosynthesis of ecdysone
Haag, T., Hétru, C., Kappler, C., Moustier, A. M., Hoffmann, J. A., & Luu, B. (1988) · Tetrahedron · doi:10.1016/s0040-4020(01)85918-4 · Cited by 13 · see citing works
Lester, D. S., & Gilbert, L. I. (1985) · Insect Biochemistry · doi:10.1016/0020-1790(85)90096-4 · Cited by 13 · see citing works
Loeb, M. J., Kochansky, J. P., Wagner, R. M., & Bell, R. A. (1994) · Journal of Insect Physiology · doi:10.1016/0022-1910(94)90132-5 · Cited by 13 · see citing works
Rybczynski, R., & Gilbert, L. I. (1998) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(98)00083-5 · Cited by 13 · see citing works
Joly, R. A., Svahn, C. M., Bennett, R. D., & Heftmanń, E. (1969) · Phytochemistry · doi:10.1016/s0031-9422(00)88076-0 · Cited by 13 · see citing works
Towards the Elucidation of the Ecdysteroid Biosynthetic Pathway
Dauphin‐Villemant, C., Blais, C., & Lafont, R. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10781.x · Cited by 11 · see citing works
Prestwich, G. D., Angelastro, M. R., Palma, A. D., & Perino, M. A. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90182-4 · Cited by 11 · see citing works
Anuran postnasal wall homology: An experimental extirpation study
Reiss, J. O. (1998) · Journal of Morphology · doi:10.1002/(sici)1097-4687(199812)238:3 · Cited by 11 · see citing works
Synthetic molecules designed as potential inhibitors in ecdysone biosynthesis
Roussel, J. (1994) · Entomologia Experimentalis et Applicata · doi:10.1111/j.1570-7458.1994.tb01786.x · Cited by 11 · see citing works
Addition to steroid polyenes—V
Lakeman, J., Speckamp, W. N., & Huisman, H. O. (1968) · Tetrahedron · doi:10.1016/s0040-4020(01)88426-x · Cited by 11 · see citing works
Chen, J. (1999) · Insect Biochemistry and Molecular Biology · doi:10.1016/s0965-1748(99)00065-x · Cited by 10 · see citing works
Characteristics of poly(A)-degrading factor present in the avian oocytes and early embryos
Stępińska, U., & Olszańska, B. (1996) · Journal of Experimental Zoology · doi:10.1002/(sici)1097-010x(19960901)276:1 · Cited by 10 · see citing works
Synthesis of potential ecdysteroid precursors from Δ7,22 sterols
Hedtmann, U., Hobert, K., Milkova, T. S., & Welzel, P. (1988) · Tetrahedron · doi:10.1016/s0040-4020(01)90337-0 · Cited by 10 · see citing works
Schwab, C., & HETRU, C. (1991) · Steroids · doi:10.1016/0039-128x(91)90053-x · Cited by 9 · see citing works
Addition to steroid polyenes IV
Lakeman, J., Speckamp, W. N., & Huisman, H. O. (1967) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)89776-8 · Cited by 8 · see citing works
Synthesis and reactions of 5.alpha.,8-epidioxyandrost-6-enes
Johns, W. F. (1971) · The Journal of Organic Chemistry · doi:10.1021/jo00816a001 · Cited by 8 · see citing works
Coggins, J. R., Schaefer, F. W., & Weinstein, P. P. (1985) · Journal of Invertebrate Pathology · doi:10.1016/0022-2011(85)90106-5 · Cited by 7 · see citing works
Mechanistic and metabolic studies of sterol 24,25-double bond reduction inManduca sexta
Short, J. D., Guo, D., Svoboda, J. A., & Nes, W. D. (1996) · Archives of Insect Biochemistry and Physiology · doi:10.1002/(sici)1520-6327(1996)31:1 · Cited by 7 · see citing works
Fujimoto, Y., Nagakari, M., Ikuina, Y., Ikekawa, N., & Kakinuma, S. (1991) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c39910000688 · Cited by 7 · see citing works
Fujimoto, Y., Ikuina, Y., & Kakinuma, S. (1989) · Journal of the Chemical Society Chemical Communications · doi:10.1039/c39890000464 · Cited by 6 · see citing works
1291. Photo-oxygenation of 3-acetoxyergosta-3,5,7,22-tetraene and related compounds.
Bladon, P., & Sleigh, T. (1965) · Journal of the Chemical Society (Resumed) · doi:10.1039/jr9650006991 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Ikeya, T., Galic, M., Belawat, P., Nairz, K., & Hafen, E. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01043-6 · Cited by 768 · see citing works
Nuclear receptors — a perspective from Drosophila
King‐Jones, K., & Thummel, C. S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1581 · Cited by 587 · see citing works
Riddiford, L. M., Hiruma, K., Zhou, X., & Nelson, C. A. (2003) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2003.06.001 · Cited by 547 · see citing works
Drosophila neuropeptides in regulation of physiology and behavior
Nässel, D. R., & Winther, Å. M. E. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.04.010 · Cited by 495 · see citing works
Petryk, A., Warren, J. T., Marqués, G., Jarcho, M. P., Gilbert, L. I., Kahler, J. L., Parvy, J.-P., Li, Y., Dauphin‐Villemant, C., & O’Connor, M. B. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336088100 · Cited by 493 · see citing works
Diabetic Larvae and Obese Flies—Emerging Studies of Metabolism in Drosophila
Baker, K. D., & Thummel, C. S. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.002 · Cited by 467 · see citing works
Size assessment and growth control: how adult size is determined in insects
Mirth, C. K., & Riddiford, L. M. (2007) · BioEssays · doi:10.1002/bies.20552 · Cited by 445 · see citing works
The Insect Neuropeptide PTTH Activates Receptor Tyrosine Kinase Torso to Initiate Metamorphosis
Rewitz, K., Yamanaka, N., Gilbert, L. I., & O’Connor, M. B. (2009) · Science · doi:10.1126/science.1176450 · Cited by 367 · see citing works
Hormonal cross talk in insect development
Dubrovsky, E. B. (2004) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2004.11.003 · Cited by 362 · see citing works
Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
Nässel, D. R., & Zandawala, M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.02.003 · Cited by 367 · see citing works
Warren, J. T., Petryk, A., Marqués, G., Jarcho, M. P., Parvy, J.-P., Dauphin‐Villemant, C., O’Connor, M. B., & Gilbert, L. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.162375799 · Cited by 335 · see citing works
Ono, H., Rewitz, K., Shinoda, T., Itoyama, K., Petryk, A., Rybczynski, R., Jarcho, M. P., Warren, J. T., Marqués, G., Shimell, M., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.07.023 · Cited by 334 · see citing works
Hormonal Control of Reproductive Processes
Raikhel, A. S., Brown, M. R., & Bellés, X. (2005) · Elsevier eBooks · doi:10.1016/b0-44-451924-6/00040-5 · Cited by 323 · see citing works
Poupardin, R., Reynaud, S., Strode, C., Ranson, H., VONTAS, J. G., & David, J. (2008) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2008.01.004 · Cited by 317 · see citing works
Niwa, R., Matsuda, T., Yoshiyama, T., Namiki, T., Mita, K., Fujimoto, Y., & Kataoka, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404514200 · Cited by 314 · see citing works
Gilbert, L. I. (2004) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2003.11.003 · Cited by 300 · see citing works
Functional Genomic Analysis of C. elegans Molting
Frand, A. R., Russel, S., & Ruvkun, G. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030312 · Cited by 297 · see citing works
Warren, J. T., Petryk, A., Marqués, G., Parvy, J.-P., Shinoda, T., Itoyama, K., Kobayashi, J., Jarcho, M. P., Li, Y., O’Connor, M. B., et al. (2004) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2004.06.009 · Cited by 296 · see citing works
The TOR Pathway Couples Nutrition and Developmental Timing in Drosophila
Layalle, S., Arquier, N., & Léopold, P. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.08.003 · Cited by 295 · see citing works
Boncristiani, H., Underwood, R. M., Schwarz, R. S., Evans, J. D., Pettis, J. S., & vanEngelsdorp, D. (2011) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2011.12.011 · Cited by 284 · see citing works
Insect Sterol Nutrition and Physiology: A Global Overview
Behmer, S. T., & Nes, W. D. (2003) · Advances in insect physiology · doi:10.1016/s0065-2806(03)31001-x · Cited by 281 · see citing works
Caldwell, P. E., Walkiewicz, M. A., & Stern, M. (2005) · Current Biology · doi:10.1016/j.cub.2005.09.011 · Cited by 268 · see citing works
Arthropod nuclear receptors and their role in molting
Nakagawa, Y., & Henrich, V. C. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07347.x · Cited by 255 · see citing works
Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor
Billas, I. M. L., Iwema, T., Garnier, J., Mitschler, A., Rochel, N., & Moras, D. (2003) · Nature · doi:10.1038/nature02112 · Cited by 254 · see citing works
Enzymes for ecdysteroid biosynthesis: Their biological functions in insects and beyond
Niwa, R., & Niwa, Y. S. (2014) · Bioscience, Biotechnology, and Biochemistry · doi:10.1080/09168451.2014.942250 · Cited by 249 · see citing works
Yoshiyama, T., Namiki, T., Mita, K., Kataoka, H., & Niwa, R. (2006) · Development · doi:10.1242/dev.02428 · Cited by 248 · see citing works
The Drosophila Orphan Nuclear Receptor DHR38 Mediates an Atypical Ecdysteroid Signaling Pathway
Baker, K. D., Shewchuk, L. M., Kozlova, T., Makishima, M., Hassell, A. M., Wisely, B., Caravella, J. A., Lambert, M. H., Reinking, J. L., Krause, H. M., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00420-3 · Cited by 238 · see citing works
Hansen, I. A., Attardo, G. M., Rodriguez, S. D., & Drake, L. L. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00103 · Cited by 198 · see citing works
Marine invertebrate cytochrome P450: Emerging insights from vertebrate and insect analogies
Rewitz, K., Styrishave, B., Løbner‐Olesen, A., & Andersen, O. (2006) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2006.04.001 · Cited by 199 · see citing works
Kanost, M. R., Arrese, E. L., Cao, X., Chen, Y.-R., Chellapilla, S., Goldsmith, M. R., Große‐Wilde, E., Heckel, D. G., Herndon, N., Jiang, H., et al. (2016) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2016.07.005 · Cited by 197 · see citing works
Neuroendocrine regulation of Drosophila metamorphosis requires TGFβ/Activin signaling
Gibbens, Y., Warren, J. T., Gilbert, L. I., & O’Connor, M. B. (2011) · Development · doi:10.1242/dev.063412 · Cited by 194 · see citing works
Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis
Koyama, T., Rodrigues, M. A., Athanasiadis, A., Shingleton, A. W., & Mirth, C. K. (2014) · eLife · doi:10.7554/elife.03091 · Cited by 184 · see citing works
Independent elaboration of steroid hormone signaling pathways in metazoans
Markov, G. V., Tavares, R., Dauphin-Villemant, C., Demeneix, B. A., Baker, M. E., & Laudet, V. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812138106 · Cited by 187 · see citing works
Dilp8 requires the neuronal relaxin receptor Lgr3 to couple growth to developmental timing
Garelli, A., Herédia, F., Casimiro, A. P., Macedo, A., Nunes, C., Garcez, M., Dias, A. R. M., Volonté, Y., Uhlmann, T., Caparrós, E., et al. (2015) · Nature Communications · doi:10.1038/ncomms9732 · Cited by 190 · see citing works
Cholesterol in health and disease
Tabas, I. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0216381 · Cited by 190 · see citing works
Cytochrome P450 CYP307A1/Spook: A regulator for ecdysone synthesis in insects
Namiki, T., Niwa, R., Sakudoh, T., Shirai, K.-I., Takeuchi, H., & Kataoka, H. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.09.043 · Cited by 189 · see citing works
Niwa, R., Namiki, T., Ito, K., Shimada‐Niwa, Y., Kiuchi, M., Kawaoka, S., Kayukawa, T., Banno, Y., Fujimoto, Y., Shigenobu, S., et al. (2010) · Development · doi:10.1242/dev.045641 · Cited by 185 · see citing works
Integrating Body and Organ Size in Drosophila: Recent Advances and Outstanding Problems
Mirth, C. K., & Shingleton, A. W. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00049 · Cited by 180 · see citing works
Rewitz, K., Rybczynski, R., Warren, J. T., & Gilbert, L. I. (2006) · Biochemical Society Transactions · doi:10.1042/bst0341256 · Cited by 179 · see citing works
Hauser, F., Neupert, S., Williamson, M. P., Predel, R., Tanaka, Y., & Grimmelikhuijzen, C. J. P. (2010) · Journal of Proteome Research · doi:10.1021/pr100570j · Cited by 176 · see citing works
Regulation of Body Size and Growth Control
Texada, M., Koyama, T., & Rewitz, K. (2020) · Genetics · doi:10.1534/genetics.120.303095 · Cited by 129 · see citing works
The Conserved Rieske Oxygenase DAF-36/Neverland Is a Novel Cholesterol-metabolizing Enzyme
Yoshiyama, T., Enya, S., Shimada‐Niwa, Y., Yaguchi, S., Haramoto, Y., Matsuya, T., Shiomi, K., Sasakura, Y., Takahashi, S., Asashima, M., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.244384 · Cited by 175 · see citing works
Xu, W. ‐., & Denlinger, D. L. (2003) · Insect Molecular Biology · doi:10.1046/j.1365-2583.2003.00437.x · Cited by 174 · see citing works
Myers, E. M., Yu, J., & Sehgal, A. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00167-2 · Cited by 171 · see citing works
Ecdysteroid Chemistry and Biochemistry
Lafont, R., Dauphin‐Villemant, C., Warren, J. T., & Rees, H. H. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-384749-2.10004-4 · Cited by 167 · see citing works
Cholesterol in health and disease
Tabas, I. A. (2002) · Journal of Clinical Investigation · doi:10.1172/jci16381 · Cited by 167 · see citing works
Steroid signaling in plants and insects—common themes, different pathways
Thummel, C. S., & Chory, J. (2002) · Genes & Development · doi:10.1101/gad.1042102 · Cited by 161 · see citing works
Metabolism and growth adaptation to environmental conditions in Drosophila
Koyama, T., Texada, M. J., Halberg, K. A., & Rewitz, K. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03547-2 · Cited by 152 · see citing works
Huang, X., Warren, J. T., Buchanan, J., Gilbert, L. I., & Scott, M. P. (2007) · Development · doi:10.1242/dev.004572 · Cited by 156 · see citing works
Owusu-Ansah, E., & Perrimon, N. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.012989 · Cited by 153 · see citing works
Parvy, J.-P., Blais, C., Bernard, F., Warren, J. T., Petryk, A., Gilbert, L. I., O’Connor, M. B., & Dauphin‐Villemant, C. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.02.028 · Cited by 149 · see citing works
Huang, X., Suyama, K. L., Buchanan, J., Zhu, A. J., & Scott, M. P. (2005) · Development · doi:10.1242/dev.02079 · Cited by 149 · see citing works
Control of ecdysteroidogenesis in prothoracic glands of insects: A review
Marchal, E., Vandersmissen, H. P., Badisco, L., de Velde, S. V., Verlinden, H., Iga, M., Wielendaele, P. V., Huybrechts, R., Simonet, G., Smagghe, G. J., et al. (2009) · Peptides · doi:10.1016/j.peptides.2009.08.020 · Cited by 148 · see citing works
Developmental Checkpoints and Feedback Circuits Time Insect Maturation
Rewitz, K., Yamanaka, N., & O’Connor, M. B. (2013) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-385979-2.00001-0 · Cited by 143 · see citing works
Koyama, T., Mendes, C. C., & Mirth, C. K. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00263 · Cited by 141 · see citing works
Rewitz, K., & Gilbert, L. I. (2008) · BMC Evolutionary Biology · doi:10.1186/1471-2148-8-60 · Cited by 139 · see citing works
Ecdysteroid Chemistry and Biochemistry
Lafont, R., Dauphin‐Villemant, C., Warren, J. T., & Rees, H. (2005) · Elsevier eBooks · doi:10.1016/b0-44-451924-6/00035-1 · Cited by 136 · see citing works
Ecological significance of sterols in aquatic food webs
Martin‐Creuzburg, D., & von Elert, E. (2009) · Springer eBooks · doi:10.1007/978-0-387-89366-2_3 · Cited by 137 · see citing works
Post-transcriptional regulation of insect metamorphosis and oogenesis
Song, J., & Zhou, S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03361-5 · Cited by 136 · see citing works
Nuclear Receptor DHR4 Controls the Timing of Steroid Hormone Pulses During Drosophila Development
Ou, Q., Magico, A., & King‐Jones, K. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001160 · Cited by 135 · see citing works
Rybczynski, R. (2005) · Elsevier eBooks · doi:10.1016/b0-44-451924-6/00033-8 · Cited by 133 · see citing works
A Molecular Genetic Approach to the Biosynthesis of the Insect Steroid Molting Hormone
Gilbert, L. I., & Warren, J. T. (2005) · Vitamins and hormones · doi:10.1016/s0083-6729(05)73002-8 · Cited by 131 · see citing works
Gonadal Ecdysteroidogenesis in Arthropoda: Occurrence and Regulation
Brown, M. R., Sieglaff, D. H., & Rees, H. H. (2008) · Annual Review of Entomology · doi:10.1146/annurev.ento.53.103106.093334 · Cited by 129 · see citing works
Niwa, Y. S., & Niwa, R. (2015) · Development Growth & Differentiation · doi:10.1111/dgd.12248 · Cited by 128 · see citing works
Yamanaka, N., Hua, Y., Roller, L., Spalovská, I., Mizoguchi, A., Kataoka, H., & Tanaka, Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907471107 · Cited by 126 · see citing works
Steroid Hormone Inactivation Is Required during the Juvenile-Adult Transition in Drosophila
Rewitz, K., Yamanaka, N., & O’Connor, M. B. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.10.021 · Cited by 124 · see citing works
Niwa, R., Sakudoh, T., Namiki, T., Saida, K., Fujimoto, Y., & Kataoka, H. (2005) · Insect Molecular Biology · doi:10.1111/j.1365-2583.2005.00587.x · Cited by 120 · see citing works
The Phytochemical, Biological, and Medicinal Attributes of Phytoecdysteroids: An Updated Review
Das, N., Mishra, S. K., Bishayee, A., Ali, E. S., & Bishayee, A. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.10.012 · Cited by 115 · see citing works
Life-History Evolution and the Polyphenic Regulation of Somatic Maintenance and Survival
Flatt, T., Amdam, G. V., Kirkwood, T. B. L., & Omholt, S. W. (2013) · The Quarterly Review of Biology · doi:10.1086/671484 · Cited by 114 · see citing works
Elias-Neto, M., Soares, M. P. M., Simões, Z. L. P., Hartfelder, K., & Bitondi, M. M. G. (2010) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2010.02.004 · Cited by 113 · see citing works
Structural and Functional Evolution of the Translocator Protein (18 kDa)
Fan, J., Lindemann, P., Feuilloley, M. G. J., & Papadopoulos, V. (2012) · Current Molecular Medicine · doi:10.2174/1566524011207040369 · Cited by 113 · see citing works
Dynamic regulation of Drosophila nuclear receptor activity in vivo
Musselman, L. P., Necakov, A., Sampson, H. M., Ni, R., Hu, C., Thummel, C. S., & Krause, H. M. (2006) · Development · doi:10.1242/dev.02512 · Cited by 110 · see citing works
Poupardin, R., Schöttner, K., Korbelová, J., Provazník, J., Doležel, D., Pavlinić, D., Beneš, V., & Košťál, V. (2015) · BMC Genomics · doi:10.1186/s12864-015-1907-4 · Cited by 106 · see citing works
Rewitz, K., Rybczynski, R., Warren, J. T., & Gilbert, L. I. (2006) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2005.12.002 · Cited by 106 · see citing works
Hu, B. H., Hu, S., Huang, H., Wei, Q., Ren, M., Huang, S., Tian, X., & Su, J. (2019) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2019.01.008 · Cited by 105 · see citing works
Enya, S., Ameku, T., Igarashi, F., Iga, M., Kataoka, H., Shinoda, T., & Niwa, R. (2014) · Scientific Reports · doi:10.1038/srep06586 · Cited by 103 · see citing works
Intercellular signaling of reproductive development by theC. elegansDAF-9 cytochrome P450
Mak, H. Y., & Ruvkun, G. (2004) · Development · doi:10.1242/dev.01069 · Cited by 103 · see citing works
Zipper, L., Jassmann, D., Burgmer, S., Görlich, B., & Reiff, T. (2020) · eLife · doi:10.7554/elife.55795 · Cited by 98 · see citing works
Halloween genes and nuclear receptors in ecdysteroid biosynthesis and signalling in the pea aphid
Christiaens, O., Iga, M., Velarde, R. A., Rougé, P., & Smagghe, G. J. (2010) · Insect Molecular Biology · doi:10.1111/j.1365-2583.2009.00957.x · Cited by 96 · see citing works
Identification of a Novel Prothoracicostatic Hormone and Its Receptor in the Silkworm Bombyx mori
Yamanaka, N., Hua, Y., Mizoguchi, A., Watanabe, K., Niwa, R., Tanaka, Y., & Kataoka, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500308200 · Cited by 96 · see citing works
Ecdysone agonists: Mechanism and importance in controlling insect pests of agriculture and forestry
Retnakaran, A., Krell, P. J., Feng, Q., & Arif, B. M. (2003) · Archives of Insect Biochemistry and Physiology · doi:10.1002/arch.10116 · Cited by 93 · see citing works
Watanabe, K., Hull, J. J., Niimi, T., Imai, K., Matsumoto, S., Yaginuma, T., & Kataoka, H. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.008 · Cited by 89 · see citing works
Li, J., Brown, G., Ailion, M., Lee, S., & Thomas, J. H. (2004) · Development · doi:10.1242/dev.01408 · Cited by 89 · see citing works
Regulation of insect steroid hormone biosynthesis by innervating peptidergic neurons
Yamanaka, N., Žitňan, D., Kim, Y., Adams, M. E., Hua, Y., Suzuki, Y., Suzuki, M., Suzuki, A., Satake, H., Mizoguchi, A., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511196103 · Cited by 89 · see citing works
Sieglaff, D. H., Duncan, K. A., & Brown, M. R. (2005) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2005.01.011 · Cited by 87 · see citing works
Structure of the heterodimeric ecdysone receptor DNA‐binding complex
Devarakonda, S., Harp, J. M., Kim, Y., Ożyhar, A., & Rastinejad, F. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg569 · Cited by 87 · see citing works
Insulin stimulates ecdysteroidogenesis by prothoracic glands in the silkworm, Bombyx mori
Gu, S., Lin, J., Lin, P., & Chen, C.-H. (2008) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2008.10.012 · Cited by 86 · see citing works
Ou, Q., & King‐Jones, K. (2013) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-385979-2.00002-2 · Cited by 86 · see citing works
Marchal, E., Badisco, L., Verlinden, H., Vandersmissen, T., Soest, S. V., Wielendaele, P. V., & Broeck, J. V. (2011) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2011.05.009 · Cited by 85 · see citing works
Bracoviruses Contain a Large Multigene Family Coding for Protein Tyrosine Phosphatases
Provost, B., Varricchio, P., Arana, E. I., Espagne, E., Falabella, P., Huguet, E., Scaleia, R. L., Cattolico, L., Poirié, M., Malva, C., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.23.13090-13103.2004 · Cited by 85 · see citing works
Wei, Z., Zhang, Q., Kang, L., Xu, W., & Denlinger, D. L. (2005) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2005.03.005 · Cited by 84 · see citing works
Techa, S., & Chung, J. S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117278 · Cited by 83 · see citing works
Critical Role of Desolvation in the Binding of 20-Hydroxyecdysone to the Ecdysone Receptor
Browning, C., Martin, E., Loch, C., Wurtz, J., Moras, D., Stote, R. H., Dejaegere, A. P., & Billas, I. M. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705559200 · Cited by 83 · see citing works
Smith, W. A., & Rybczynski, R. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-384749-2.10001-9 · Cited by 83 · see citing works
Regulation of ecdysone production in <i>Drosophila</i> by neuropeptides and peptide hormones
Kannangara, J. R., Mirth, C. K., & Warr, C. G. (2021) · Open Biology · doi:10.1098/rsob.200373 · Cited by 84 · see citing works
Iga, M., & Smagghe, G. J. (2009) · Peptides · doi:10.1016/j.peptides.2009.08.002 · Cited by 82 · see citing works
Rhodnius, Golden Oil, and Met: A History of Juvenile Hormone Research
Riddiford, L. M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00679 · Cited by 82 · see citing works
Niwa, R., & Niwa, Y. S. (2011) · Cholesterol · doi:10.1155/2011/176802 · Cited by 82 · see citing works
Strode, C., Steen, K., Ortelli, F., & Ranson, H. (2006) · Insect Molecular Biology · doi:10.1111/j.1365-2583.2006.00667.x · Cited by 82 · see citing works
Li, K., Tian, L., Guo, Z., Guo, S., Zhang, J., Gu, S., Palli, S. R., Cao, Y., & Li, S. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.737072 · Cited by 81 · see citing works
- Authors
- Gilbert, L. I., Rybczynski, R., & Warren, J. T.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Venue
- Annual Review of Entomology
- Publisher
- Annual Reviews
- Published
- 2002-01
- Volume
- 47
- Issue
- 1
- Pages
- 883-916
- ISSN
- 0066-4170 (ISSN-L)
- 1545-4487
- OpenAlex
- W2157228103
- Cited by
- 532
- References
- 185
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 16 · 2023: 14 · 2022: 14 · 2021: 21 · 2020: 32 · 2019: 20 · 2018: 11 · 2017: 13 · 2016: 20 · 2015: 21 · 2014: 31 · 2013: 28 · 2012: 26
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Entomology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- ecdysteroid biosynthesis, 20-hydroxyecdysone, ecdysone, prothoracic gland, prothoracicotropic hormone, molting, metamorphosis, cholesterol conversion, steroidogenesis, insect endocrinology
- MeSH terms
- Animals, Insecta, Down-Regulation, Ecdysteroids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review