Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse.
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Use of the specific-locus test to measure the frequency of transmitted gene mutations induced in mouse spermatogonia has shown ethylnitrosourea to be by far the most potent mutagen yet discovered in the mouse. The dose used, 250 mg/kg, gave a mutation rate 5 times as high as had been obtained with 600 R, the most effective acute dose of x-rays. Compared to procarbazine, heretofore the most mutagenic chemical known in the mouse, ethylnitrosourea proved to be 15 times more mutagenic than the peak effect obtained with the most effective dose of procarbazine. Because of its high mutagenicity, ethylnitrosourea can serve as a model compound in exploring the effect of such factors as dose response, dose fractionation, sex, and cell stage on the mutagenic action of a chemical. Ethylnitrosourea is clearly the mutagen of choice for the production of any kind of desired new gene mutations in the mouse.
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Human HT1 may be modeled more suitably by point mutations in mice, such as those easily induced by ENU.
“Human HT1 may be modeled more suitably by similar types of point mutations in mice, such as those easily induced by the presumed point-mutation inducer N-ethyl-N-nitrosourea (ENU; ref. 26).”
From Point mutations in the murine fumarylacetoacetate hydrolase gene: Animal models for the human genetic disorder hereditary tyrosinemia type 1 (2001) · cites this paper as [26]
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- [1]Ehling, U. H. (1978) in Chemical Mutagens, eds. Hollaender, A. & deSerres, F. J. (Plenum, New York), Vol. 5, pp. 233–256.
- [5]Russell, W. L. (1963) in Repair from Genetic Radiation Damage, ed. Sobels, F. H. (Pergamon, Oxford), pp. 205–217; 231–235.
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- Authors
- Russell, W. L., Kelly, E. M., Hunsicker, P. R., Bangham, J. W., Maddux, S. C., & Phipps, E. L.
- Affiliations
- Oak Ridge National Laboratory (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1979-11
- Volume
- 76
- Issue
- 11
- Pages
- 5818-5819
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC411742
- OpenAlex
- W2086508545
- Cited by
- 517
- References
- 0
- Citations by year
- 2025: 3 · 2024: 13 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 10 · 2019: 8 · 2018: 8 · 2017: 7 · 2016: 8 · 2015: 8 · 2014: 9 · 2013: 9 · 2012: 12
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- U.S. Department of Energy (W-7405, W-7405eng-26)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- ethylnitrosourea, mutagenicity, gene mutation frequency, procarbazine, X-ray mutagenesis, dose-response relationship, dose fractionation, chemical mutagenesis
- MeSH terms
- Alleles, Animals, Dose-Response Relationship, Drug, Ethylnitrosourea, Female, Infertility, Infertility, Male, Male, Mutagens, Nitrosourea Compounds, Spermatogonia, Mice
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